The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 536: Cyclin-dependent kinase WEE1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 P07527 (/IDA) P32944 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P07527 (/IPI) P32944 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P32944 (/HDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P07527 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 P07527 (/ISM)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
4 G5EB22 (/IMP) G5EB22 (/IMP) G5EB22 (/IMP) P32944 (/IMP)
Regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079
Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
3 G5EB22 (/IMP) G5EB22 (/IMP) G5EB22 (/IMP)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
3 G5EB22 (/IGI) G5EB22 (/IGI) G5EB22 (/IGI)
Negative regulation of cell septum assembly GO:1901892
Any process that stops, prevents or reduces the frequency, rate or extent of cell septum assembly.
3 G5EB22 (/IMP) G5EB22 (/IMP) G5EB22 (/IMP)
Regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079
Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
1 P32944 (/IDA)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
1 P32944 (/IDA)
Re-entry into mitotic cell cycle GO:0000320
The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state.
1 P32944 (/IGI)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P32944 (/HDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P32944 (/IGI)
Mitotic G2 DNA damage checkpoint GO:0007095
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
1 P07527 (/IMP)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
1 P32944 (/HMP)
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 P07527 (/IMP)
Negative regulation of mitotic spindle pole body separation GO:0010697
Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane.
1 P32944 (/IGI)
Negative regulation of mitotic spindle pole body separation GO:0010697
Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane.
1 P32944 (/IMP)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 P07527 (/EXP)
Negative regulation of G2/M transition of mitotic cell cycle GO:0010972
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 P07527 (/IMP)
Regulation of meiotic nuclear division GO:0040020
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
1 P32944 (/IMP)
Mitotic cytokinesis checkpoint GO:0044878
A mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
1 P07527 (/IMP)
Morphogenesis checkpoint GO:0044879
A mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth.
1 P32944 (/IDA)
Morphogenesis checkpoint GO:0044879
A mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth.
1 P32944 (/IMP)
Signal transduction involved in mitotic cell cycle checkpoint GO:0072413
A signal transduction process that contributes to a mitotic cell cycle checkpoint.
1 P07527 (/IGI)
Signal transduction involved in G2 cell size control checkpoint GO:0072453
A signal transduction process that contributes to a cell size control checkpoint during the G2/M transition of mitosis.
1 P07527 (/EXP)
Positive regulation of sphingolipid biosynthetic process GO:0090154
Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
1 P32944 (/IGI)
Positive regulation of sphingolipid biosynthetic process GO:0090154
Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).
1 P32944 (/IMP)
Negative regulation of G2/MI transition of meiotic cell cycle GO:0110031
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle.
1 P07527 (/IMP)
Signal transduction involved in mitotic DNA damage checkpoint GO:1902402
Any intracellular signal transduction that is involved in mitotic DNA damage checkpoint.
1 P07527 (/IGI)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P07527 (/IDA) P32944 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P07527 (/TAS)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
1 P32944 (/IDA)
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
1 P07527 (/HDA)
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
1 P07527 (/IDA)
Medial cortical node GO:0071341
A component of the cell division site that contains the mid1, cdr2, wee1, klp8, and blt1 proteins, and is involved in contractile ring localization. Medial cortical node complexes appear as cortical dots in the middle of the cell during interphase, and function to recruit other ring components in early mitosis.
1 P07527 (/IDA)
Cdr2 medial cortical node complex GO:0110115
A megadalton-sized complex organized as an oligomeric core of SAD family protein kinases involved in cell size-dependent regulation of Wee1 localization and required for phosphorylation of Wee1 in vivo.
1 P07527 (/EXP)
CATH-Gene3D is a Global Biodata Core Resource Learn more...