The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 502: Aurora kinase A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 O01427 (/IDA) Q27393 (/IDA) Q9VGF9 (/IDA)
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
2 Q27393 (/IDA) Q9VGF9 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O01427 (/IPI) Q9VGF9 (/IPI)
Histone kinase activity (H3-S10 specific) GO:0035175
Catalysis of the transfer of a phosphate group to the serine-10 residue of the N-terminal tail of histone H3.
2 O64629 (/IDA) O64629 (/IDA)
Histone kinase activity (H3-S28 specific) GO:0044022
Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3.
2 O64629 (/IDA) O64629 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 O01427 (/IDA)
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
1 O01427 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
1 O01427 (/IPI)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
3 O01427 (/IDA) Q27393 (/IDA) Q9VGF9 (/IDA)
Centrosome cycle GO:0007098
The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Mitotic centrosome separation GO:0007100
Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Pole cell formation GO:0007279
Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
2 O64629 (/IDA) O64629 (/IDA)
Histone H3-S10 phosphorylation GO:0043987
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone.
2 O64629 (/IDA) O64629 (/IDA)
Histone H3-S28 phosphorylation GO:0043988
The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.
2 O64629 (/IDA) O64629 (/IDA)
Asymmetric protein localization involved in cell fate determination GO:0045167
Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Centrosome separation GO:0051299
The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Symmetric cell division GO:0098725
Cell division in which both daughter cells are of the same type.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Regulation of cellular protein localization GO:1903827
Any process that modulates the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.
2 Q27393 (/IMP) Q9VGF9 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 O01427 (/IDA)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
1 O01427 (/IMP)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
1 O01427 (/IDA)
Chromosome condensation GO:0030261
The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
1 O01427 (/IMP)
Regulation of actomyosin contractile ring contraction GO:0031991
Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle.
1 O01427 (/IGI)
Regulation of actomyosin contractile ring contraction GO:0031991
Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle.
1 O01427 (/IMP)
Establishment of protein localization GO:0045184
The directed movement of a protein to a specific location.
1 O01427 (/IMP)
Positive regulation of DNA repair GO:0045739
Any process that activates or increases the frequency, rate or extent of DNA repair.
1 Q9VGF9 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 O01427 (/IDA)
Regulation of neurogenesis GO:0050767
Any process that modulates the frequency, rate or extent of neurogenesis, the generation of cells in the nervous system.
1 Q9VGF9 (/IMP)
Mitotic spindle midzone assembly GO:0051256
The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
1 O01427 (/IMP)
Meiotic spindle midzone assembly GO:0051257
The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.
1 O01427 (/IMP)
Establishment of spindle orientation GO:0051294
Any process that set the alignment of spindle relative to other cellular structures.
1 Q9VGF9 (/IMP)
Regulation of protein localization to cell cortex GO:1904776
Any process that modulates the frequency, rate or extent of protein localization to cell cortex.
1 Q9VGF9 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
3 O01427 (/IDA) O64629 (/IDA) O64629 (/IDA)
Chromosome, centromeric region GO:0000775
The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome.
2 O64629 (/IDA) O64629 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O64629 (/IDA) O64629 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q27393 (/IDA) Q9VGF9 (/IDA)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 Q27393 (/NAS) Q9VGF9 (/NAS)
Condensed chromosome GO:0000793
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.
1 O01427 (/IDA)
Condensed nuclear chromosome GO:0000794
A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
1 O01427 (/IDA)
Spindle midzone GO:0051233
The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
1 O01427 (/IDA)
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