The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 490: Proto-oncogene serine/threonine-protein kinase mos

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MAP kinase kinase kinase activity GO:0004709
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
14 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00536 (/ISS) P00539 (/ISS) P00540 (/ISS)
(4 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00536 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
MAP kinase kinase kinase activity GO:0004709
Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
2 P12965 (/IDA) Q9GRC0 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 P00539 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P00539 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 P00536 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P00540 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
14 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00536 (/ISS) P00539 (/ISS) P00540 (/ISS)
(4 more)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
14 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00536 (/ISS) P00539 (/ISS) P00540 (/ISS)
(4 more)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00539 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
Meiotic spindle organization GO:0000212
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00539 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00539 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
Establishment of meiotic spindle orientation GO:0051296
Any process that set the alignment of meiotic spindle relative to other cellular structures.
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00539 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
Negative regulation of metaphase/anaphase transition of meiotic cell cycle GO:1902103
Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle.
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00539 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
Negative regulation of metaphase/anaphase transition of meiotic cell cycle GO:1902103
Any process that stops, prevents or reduces the frequency, rate or extent of metaphase/anaphase transition of meiotic cell cycle.
3 P00536 (/IMP) P50118 (/IMP) P50118 (/IMP)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2 P50118 (/IMP) P50118 (/IMP)
ERK1 and ERK2 cascade GO:0070371
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
2 P50118 (/IMP) P50118 (/IMP)
Activation of MAPKK activity GO:0000186
The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).
1 P12965 (/IDA)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P00536 (/IMP)
Meiotic spindle organization GO:0000212
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
1 P00536 (/IMP)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
1 P00536 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
1 P00539 (/TAS)
Female meiosis II GO:0007147
The cell cycle process in which the second meiotic division occurs in the female germline.
1 Q9GRC0 (/IDA)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 P00539 (/NAS)
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
1 Q9GRC0 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
1 P00539 (/TAS)
Regulation of meiotic nuclear division GO:0040020
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
1 P00536 (/IGI)
Negative regulation of mitotic cell cycle GO:0045930
Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
1 Q9GRC0 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P12965 (/IDA)
Establishment of meiotic spindle orientation GO:0051296
Any process that set the alignment of meiotic spindle relative to other cellular structures.
1 P00536 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
12 F1PN64 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) F6VV07 (/ISS) H2QW68 (/ISS) H2QW68 (/ISS) P00536 (/ISS) P00540 (/ISS) P10650 (/ISS)
(2 more)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P00536 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P00539 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P00536 (/ISO)
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