The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 446: Microtubule associated serine/threonine kinase 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
2 | F4HYG2 (/ISS) F4HYG2 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
1 | Q09898 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q09898 (/EXP) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | Q09898 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q09898 (/IPI) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q09898 (/ISM) |
There are 11 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Septation initiation signaling GO:0031028
The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis.
|
1 | Q09898 (/IMP) |
|
Negative regulation of protein homooligomerization GO:0032463
Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.
|
1 | Q09898 (/IMP) |
|
Mitotic cytokinesis checkpoint GO:0044878
A mitotic cell cycle checkpoint that detects a defect in cytokinesis and prevents further rounds of nuclear division until cytokinesis is completed.
|
1 | Q09898 (/IMP) |
|
Maintenance of endoplasmic reticulum location involved in endoplasmic reticulum polarization at cell division site GO:0061167
The process in which the endoplasmic reticulum is maintained at the site of cell division and is prevented from moving elsewhere.
|
1 | Q09898 (/IMP) |
|
Regulation of protein localization to medial cortex GO:0106011
Any process that regulates the localization of a protein to the medial cortex.
|
1 | Q09898 (/EXP) |
|
Negative regulation of protein localization to microtubule GO:1902817
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to microtubule.
|
1 | Q09898 (/IMP) |
|
Positive regulation of mitotic spindle elongation GO:1902846
Any process that activates or increases the frequency, rate or extent of mitotic spindle elongation.
|
1 | Q09898 (/IMP) |
|
Positive regulation of nuclear migration during mitotic telophase GO:1902854
Any process that activates or increases the frequency, rate or extent of nuclear migration during mitotic telophase.
|
1 | Q09898 (/IMP) |
|
Positive regulation of mitotic actomyosin contractile ring contraction GO:1903473
Any process that activates or increases the frequency, rate or extent of mitotic actomyosin contractile ring contraction.
|
1 | Q09898 (/EXP) |
|
Positive regulation of primary cell septum biogenesis GO:1905758
Any process that activates or increases the frequency, rate or extent of primary cell septum biogenesis.
|
1 | Q09898 (/IMP) |
|
Negative regulation of actin cytoskeleton reorganization GO:2000250
Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization.
|
1 | Q09898 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q09898 (/IC) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q09898 (/HDA) |
|
Medial cortex GO:0031097
A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.
|
1 | Q09898 (/IDA) |
|
Sid2-Mob1 complex GO:0034973
A protein complex that contains a protein kinase (Sid2 in S. pombe) and its regulatory subunit (Mob1). The Sid2p-Mob1p kinase complex is a component of the septation initiation network in fission yeast (called the mitotic exit network in S. cerevisiae) and is required for cytokinesis. The analogous complex in S. cerevisiae is called Dbf2p-Mob1p complex.
|
1 | Q09898 (/IPI) |
|
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
|
1 | Q09898 (/HDA) |
|
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
|
1 | Q09898 (/IDA) |
|
Actomyosin contractile ring, intermediate layer GO:0120105
The region of the actomyosin ring in between the proximal layer and the actin filament layer. This region contains the accessory protein network, some actin filaments and connections between the proximal layer and the actin filament layer.
|
1 | Q09898 (/IDA) |
