The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 41: Ribosomal protein S6 kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
32 |
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
(22 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
22 |
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
P18654 (/IDA)
(12 more) |
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
20 |
P18653 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
(10 more) |
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
19 |
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
P18654 (/IPI)
(9 more) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
12 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(2 more) |
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
11 |
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
Q15418 (/IDA)
Q15418 (/IDA)
(1 more) |
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
8 | P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) |
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
3 | Q15418 (/IDA) Q15418 (/IDA) Q15418 (/IDA) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | P18653 (/ISS) Q63531 (/ISS) |
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
1 | P18653 (/ISO) |
Ribosomal protein S6 kinase activity GO:0004711
Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP.
|
1 | Q63531 (/TAS) |
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
1 | P18653 (/ISO) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q63531 (/IDA) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P18653 (/IPI) |
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | P18653 (/ISO) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | P18653 (/IDA) |
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | Q63531 (/ISS) |
There are 37 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
20 |
P18653 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
(10 more) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
20 |
P18653 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
P18654 (/ISO)
(10 more) |
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
|
19 |
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
(9 more) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
19 |
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
P18654 (/IMP)
(9 more) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
11 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(1 more) |
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
11 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(1 more) |
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
11 |
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
P51812 (/IDA)
Q15418 (/IDA)
Q15418 (/IDA)
(1 more) |
Regulation of translation in response to stress GO:0043555
Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
11 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(1 more) |
Regulation of DNA-templated transcription in response to stress GO:0043620
Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
11 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(1 more) |
Positive regulation of cell differentiation GO:0045597
Any process that activates or increases the frequency, rate or extent of cell differentiation.
|
11 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(1 more) |
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
11 |
P51812 (/IMP)
P51812 (/IMP)
P51812 (/IMP)
P51812 (/IMP)
P51812 (/IMP)
P51812 (/IMP)
P51812 (/IMP)
P51812 (/IMP)
Q15418 (/IMP)
Q15418 (/IMP)
(1 more) |
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
|
8 | P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) |
Toll-like receptor signaling pathway GO:0002224
Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.
|
8 | P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) |
Central nervous system development GO:0007417
The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
|
8 | P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) |
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
8 | P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
8 | P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) P51812 (/ISS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
8 | P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) P51812 (/TAS) |
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
6 | A0A2R8QC98 (/IGI) A0A2R8QG28 (/IGI) A2RUY2 (/IGI) E7F469 (/IGI) E9QIU5 (/IGI) F1R2A7 (/IGI) |
Skin development GO:0043588
The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue.
|
4 | A0A0R4ID09 (/IGI) A0A2R8Q8Y4 (/IGI) B0R0M9 (/IGI) Q7ZVH8 (/IGI) |
Digestive tract development GO:0048565
The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed.
|
4 | A0A0R4ID09 (/IMP) A0A2R8Q8Y4 (/IMP) B0R0M9 (/IMP) Q7ZVH8 (/IMP) |
Hepatocyte proliferation GO:0072574
The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
|
4 | Q15418 (/ISS) Q15418 (/ISS) Q15418 (/ISS) Q63531 (/ISS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | Q15418 (/IMP) Q15418 (/IMP) Q15418 (/IMP) |
Positive regulation of hepatic stellate cell activation GO:2000491
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
|
3 | Q15418 (/IMP) Q15418 (/IMP) Q15418 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
2 | P18653 (/ISS) Q63531 (/ISS) |
Positive regulation of hepatic stellate cell activation GO:2000491
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
|
2 | P18653 (/ISS) Q63531 (/ISS) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q63531 (/IDA) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P18653 (/ISO) |
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
|
1 | Q7TPS0 (/ISO) |
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978
A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage.
|
1 | Q7TPS0 (/ISS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P18653 (/ISO) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q63531 (/IDA) |
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P18653 (/ISO) |
Negative regulation of embryonic development GO:0045992
Any process that stops, prevents, or reduces the frequency, rate or extent of embryonic development.
|
1 | Q7TPS0 (/IDA) |
Negative regulation of ERK1 and ERK2 cascade GO:0070373
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | Q7TPS0 (/IDA) |
Hepatocyte proliferation GO:0072574
The multiplication or reproduction of hepatocytes, resulting in the expansion of a cell population. Hepatocytes form the main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules.
|
1 | P18653 (/IDA) |
Negative regulation of mesoderm development GO:2000381
Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development.
|
1 | Q7TPS0 (/IDA) |
Positive regulation of hepatic stellate cell activation GO:2000491
Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.
|
1 | P18653 (/ISO) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
30 |
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
P18654 (/TAS)
(20 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
12 |
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
P51812 (/TAS)
Q15418 (/TAS)
Q15418 (/TAS)
(2 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
6 | E9PGT3 (/IDA) E9PGT3 (/IDA) Q15418 (/IDA) Q15418 (/IDA) Q15418 (/IDA) Q63531 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
5 | E9PGT3 (/IDA) E9PGT3 (/IDA) Q15418 (/IDA) Q15418 (/IDA) Q15418 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P18653 (/ISO) Q7TPS0 (/ISO) |
Fibrillar center GO:0001650
A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures.
|
1 | Q7TPS0 (/ISO) |
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
|
1 | Q7TPS0 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q63531 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P18653 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q7TPS0 (/ISO) |
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
|
1 | P18653 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P18653 (/ISO) |