The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 405: Mitogen-activated protein kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
3-phosphoinositide-dependent protein kinase activity GO:0004676
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate.
2 Q9W0V1 (/IDA) Q9W0V1 (/IDA)
3-phosphoinositide-dependent protein kinase activity GO:0004676
Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate.
2 Q9W0V1 (/TAS) Q9W0V1 (/TAS)
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
2 Q9W0V1 (/IDA) Q9W0V1 (/IDA)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 Q9W0V1 (/IDA) Q9W0V1 (/IDA)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
2 Q9W0V1 (/IGI) Q9W0V1 (/IGI)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 Q9W0V1 (/TAS) Q9W0V1 (/TAS)
Female gamete generation GO:0007292
Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.
2 Q9W0V1 (/TAS) Q9W0V1 (/TAS)
Sex differentiation GO:0007548
The establishment of the sex of an organism by physical differentiation.
2 Q9W0V1 (/TAS) Q9W0V1 (/TAS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
2 Q9W0V1 (/IGI) Q9W0V1 (/IGI)
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 Q9W0V1 (/IDA) Q9W0V1 (/IDA)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
2 Q9W0V1 (/IGI) Q9W0V1 (/IGI)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
2 Q9W0V1 (/TAS) Q9W0V1 (/TAS)
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Synaptic growth at neuromuscular junction GO:0051124
The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
2 Q9W0V1 (/IMP) Q9W0V1 (/IMP)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9W0V1 (/HDA) Q9W0V1 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9W0V1 (/HDA) Q9W0V1 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9W0V1 (/ISS) Q9W0V1 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9W0V1 (/HDA) Q9W0V1 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q9W0V1 (/TAS) Q9W0V1 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9W0V1 (/ISS) Q9W0V1 (/ISS)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
2 Q9W0V1 (/IDA) Q9W0V1 (/IDA)
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