The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 373: Receptor protein-tyrosine kinase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
15 B6IDV6 (/ISS) E1JHB6 (/ISS) E1JHB7 (/ISS) E1JHB8 (/ISS) M9MRE1 (/ISS) M9PCJ1 (/ISS) M9PCX2 (/ISS) Q7KTI7 (/ISS) Q7KTI8 (/ISS) Q8IPG1 (/ISS)
(5 more)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 E1JHB7 (/IDA)
Transmembrane receptor protein tyrosine kinase activity GO:0004714
Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
1 E1JHB7 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 E1JHB7 (/IPI)
Vascular endothelial growth factor binding GO:0038085
Interacting selectively and non-covalently with a vascular endothelial growth factor.
1 E1JHB7 (/IPI)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Malpighian tubule morphogenesis GO:0007443
The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Cell projection assembly GO:0030031
Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
15 B6IDV6 (/IEP) E1JHB6 (/IEP) E1JHB7 (/IEP) E1JHB8 (/IEP) M9MRE1 (/IEP) M9PCJ1 (/IEP) M9PCX2 (/IEP) Q7KTI7 (/IEP) Q7KTI8 (/IEP) Q8IPG1 (/IEP)
(5 more)
Hemocyte migration GO:0035099
The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
15 B6IDV6 (/IGI) E1JHB6 (/IGI) E1JHB7 (/IGI) E1JHB8 (/IGI) M9MRE1 (/IGI) M9PCJ1 (/IGI) M9PCX2 (/IGI) Q7KTI7 (/IGI) Q7KTI8 (/IGI) Q8IPG1 (/IGI)
(5 more)
Intestinal stem cell homeostasis GO:0036335
Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
15 B6IDV6 (/ISS) E1JHB6 (/ISS) E1JHB7 (/ISS) E1JHB8 (/ISS) M9MRE1 (/ISS) M9PCJ1 (/ISS) M9PCX2 (/ISS) Q7KTI7 (/ISS) Q7KTI8 (/ISS) Q8IPG1 (/ISS)
(5 more)
Imaginal disc-derived male genitalia morphogenesis GO:0048803
The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Anterior Malpighian tubule development GO:0061327
The process whose specific outcome is the progression of the anterior Malpighian tubule over time, from its formation to the mature structure. The pair of anterior tubules arise from a dorsal region of the embryonic hindgut and projects forwards through the body cavity. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which connects with the posterior part of the gut.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Positive regulation of border follicle cell migration GO:1903688
Any process that activates or increases the frequency, rate or extent of border follicle cell migration.
15 B6IDV6 (/IMP) E1JHB6 (/IMP) E1JHB7 (/IMP) E1JHB8 (/IMP) M9MRE1 (/IMP) M9PCJ1 (/IMP) M9PCX2 (/IMP) Q7KTI7 (/IMP) Q7KTI8 (/IMP) Q8IPG1 (/IMP)
(5 more)
Negative regulation of humoral immune response GO:0002921
Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response.
1 E1JHB7 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
1 E1JHB7 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
1 E1JHB7 (/IMP)
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
1 E1JHB7 (/IMP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 E1JHB7 (/IMP)
Larval lymph gland hemopoiesis GO:0035167
The production of blood cells from the larval lymph gland. The lymph gland consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
1 E1JHB7 (/IMP)
Wound healing, spreading of epidermal cells GO:0035313
The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
1 E1JHB7 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 E1JHB7 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
1 E1JHB7 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 E1JHB7 (/IDA)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 E1JHB7 (/IGI)
Imaginal disc fusion, thorax closure GO:0046529
The joining of the parts of the wing imaginal discs, giving rise to the adult thorax.
1 E1JHB7 (/IMP)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 E1JHB7 (/IDA)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 E1JHB7 (/IGI)
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 E1JHB7 (/IMP)
Lymph gland development GO:0048542
The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is one of the sites of hemocyte differentiation. It consists of three to six bilaterally paired lobes that are attached to the cardioblasts during larval stages, and it degenerates during pupal stages.
1 E1JHB7 (/IMP)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
1 E1JHB7 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 E1JHB7 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 E1JHB7 (/IMP)
Positive regulation of border follicle cell migration GO:1903688
Any process that activates or increases the frequency, rate or extent of border follicle cell migration.
1 E1JHB7 (/IGI)
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
1 E1JHB7 (/IMP)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 E1JHB7 (/IDA)
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