The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 37: Serine/threonine-protein kinase tousled-like 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
17 B7Z120 (/IPI) B7Z126 (/IPI) M9PDQ2 (/IPI) M9PIZ6 (/IPI) Q1RL19 (/IPI) Q86UE8 (/IPI) Q8IRT7 (/IPI) Q8IRT8 (/IPI) Q9UKI8 (/IPI) Q9UKI8 (/IPI)
(7 more)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
10 B7Z120 (/ISS) B7Z126 (/ISS) M9PDQ2 (/ISS) M9PIZ6 (/ISS) O55047 (/ISS) Q1RL19 (/ISS) Q8C0V0 (/ISS) Q8IRT7 (/ISS) Q8IRT8 (/ISS) Q9W4Q4 (/ISS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
9 Q86UE8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
9 Q86UE8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
8 B7Z120 (/IDA) B7Z126 (/IDA) M9PDQ2 (/IDA) M9PIZ6 (/IDA) Q1RL19 (/IDA) Q8IRT7 (/IDA) Q8IRT8 (/IDA) Q9W4Q4 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
8 Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 O55047 (/ISO) Q8C0V0 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 O55047 (/ISO) Q8C0V0 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
2 O55047 (/ISS) Q8C0V0 (/ISS)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
17 B7Z120 (/IDA) B7Z126 (/IDA) M9PDQ2 (/IDA) M9PIZ6 (/IDA) Q1RL19 (/IDA) Q86UE8 (/IDA) Q8IRT7 (/IDA) Q8IRT8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA)
(7 more)
Regulation of chromatin assembly or disassembly GO:0001672
Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.
9 Q86UE8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
9 Q86UE8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA)
Chromatin organization GO:0006325
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin.
8 B7Z120 (/IGI) B7Z126 (/IGI) M9PDQ2 (/IGI) M9PIZ6 (/IGI) Q1RL19 (/IGI) Q8IRT7 (/IGI) Q8IRT8 (/IGI) Q9W4Q4 (/IGI)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
8 Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA) Q9UKI8 (/IDA)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
8 B7Z120 (/IGI) B7Z126 (/IGI) M9PDQ2 (/IGI) M9PIZ6 (/IGI) Q1RL19 (/IGI) Q8IRT7 (/IGI) Q8IRT8 (/IGI) Q9W4Q4 (/IGI)
Histone phosphorylation GO:0016572
The modification of histones by addition of phosphate groups.
8 B7Z120 (/IMP) B7Z126 (/IMP) M9PDQ2 (/IMP) M9PIZ6 (/IMP) Q1RL19 (/IMP) Q8IRT7 (/IMP) Q8IRT8 (/IMP) Q9W4Q4 (/IMP)
Antimicrobial humoral response GO:0019730
An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus.
8 B7Z120 (/IMP) B7Z126 (/IMP) M9PDQ2 (/IMP) M9PIZ6 (/IMP) Q1RL19 (/IMP) Q8IRT7 (/IMP) Q8IRT8 (/IMP) Q9W4Q4 (/IMP)
Mitotic cell cycle, embryonic GO:0045448
The eukaryotic cell cycle in which a cell is duplicated without changing ploidy, occurring in the embryo.
8 B7Z120 (/IMP) B7Z126 (/IMP) M9PDQ2 (/IMP) M9PIZ6 (/IMP) Q1RL19 (/IMP) Q8IRT7 (/IMP) Q8IRT8 (/IMP) Q9W4Q4 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
8 B7Z120 (/IDA) B7Z126 (/IDA) M9PDQ2 (/IDA) M9PIZ6 (/IDA) Q1RL19 (/IDA) Q8IRT7 (/IDA) Q8IRT8 (/IDA) Q9W4Q4 (/IDA)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
8 B7Z120 (/IMP) B7Z126 (/IMP) M9PDQ2 (/IMP) M9PIZ6 (/IMP) Q1RL19 (/IMP) Q8IRT7 (/IMP) Q8IRT8 (/IMP) Q9W4Q4 (/IMP)
Heterochromatin organization involved in chromatin silencing GO:0070868
Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic heterochromatin and contributes to chromatin silencing.
8 B7Z120 (/IMP) B7Z126 (/IMP) M9PDQ2 (/IMP) M9PIZ6 (/IMP) Q1RL19 (/IMP) Q8IRT7 (/IMP) Q8IRT8 (/IMP) Q9W4Q4 (/IMP)
Regulation of chromatin assembly or disassembly GO:0001672
Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.
2 O55047 (/ISO) Q8C0V0 (/ISO)
Regulation of chromatin assembly or disassembly GO:0001672
Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly.
2 O55047 (/ISS) Q8C0V0 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 O55047 (/ISO) Q8C0V0 (/ISO)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
2 O55047 (/ISS) Q8C0V0 (/ISS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 O55047 (/ISO) Q8C0V0 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
2 O55047 (/ISS) Q8C0V0 (/ISS)
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
1 Q8C0V0 (/ISO)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 Q86UE8 (/IDA)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
1 O55047 (/ISO)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
1 Q86UE8 (/IMP)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
1 O55047 (/ISO)
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
1 O55047 (/ISS)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q86UE8 (/NAS)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 Q86UE8 (/IDA)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 O55047 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 O55047 (/ISS)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 Q86UE8 (/IMP)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 O55047 (/ISO)
Negative regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032435
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 O55047 (/ISS)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 Q86UE8 (/IDA)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
1 O55047 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
18 B7Z120 (/IDA) B7Z126 (/IDA) M9PDQ2 (/IDA) M9PIZ6 (/IDA) O55047 (/IDA) Q1RL19 (/IDA) Q86UE8 (/IDA) Q8IRT7 (/IDA) Q8IRT8 (/IDA) Q9UKI8 (/IDA)
(8 more)
Heterochromatin GO:0000792
A compact and highly condensed form of chromatin.
8 B7Z120 (/IDA) B7Z126 (/IDA) M9PDQ2 (/IDA) M9PIZ6 (/IDA) Q1RL19 (/IDA) Q8IRT7 (/IDA) Q8IRT8 (/IDA) Q9W4Q4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
8 Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS) Q9UKI8 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
8 B7Z120 (/HDA) B7Z126 (/HDA) M9PDQ2 (/HDA) M9PIZ6 (/HDA) Q1RL19 (/HDA) Q8IRT7 (/HDA) Q8IRT8 (/HDA) Q9W4Q4 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O55047 (/ISO) Q8C0V0 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O55047 (/ISS) Q8C0V0 (/ISS)
Intermediate filament GO:0005882
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
2 O55047 (/IDA) Q86UE8 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 O55047 (/IDA) Q86UE8 (/IDA)
Intermediate filament GO:0005882
A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.
1 O55047 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 O55047 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...