The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 33: Non-specific serine/threonine protein kinase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 47 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
56 |
A0A0B8RZS0 (/IPI)
A0A0B8RZS0 (/IPI)
B0LPE5 (/IPI)
B0LPE5 (/IPI)
B0LPE5 (/IPI)
B0LPE5 (/IPI)
B0LPE5 (/IPI)
B0LPE5 (/IPI)
B0LPE5 (/IPI)
G9BWQ2 (/IPI)
(46 more) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
43 |
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31750 (/IDA)
P31751 (/IDA)
P47196 (/IDA)
(33 more) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
37 |
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31751 (/IDA)
P47196 (/IDA)
P47197 (/IDA)
(27 more) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
33 |
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
(23 more) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
12 |
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31750 (/TAS)
P31751 (/TAS)
P47196 (/TAS)
(2 more) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
9 | P31749 (/EXP) P31749 (/EXP) P31749 (/EXP) P31749 (/EXP) P31749 (/EXP) P31749 (/EXP) P31749 (/EXP) Q60823 (/EXP) Q60823 (/EXP) |
|
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
9 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) Q17941 (/IDA) Q9XTG7 (/IDA) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
8 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) Q17941 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
7 | P31749 (/IC) P31749 (/IC) P31749 (/IC) P31749 (/IC) P31749 (/IC) P31749 (/IC) P31749 (/IC) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
7 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) |
|
Nitric-oxide synthase regulator activity GO:0030235
Modulates the activity of nitric oxide synthase.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
7 | P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
7 | P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) P31749 (/IPI) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
6 | P31750 (/IDA) P47196 (/IDA) Q17941 (/IDA) Q60823 (/IDA) Q60823 (/IDA) Q9XTG7 (/IDA) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
6 | A0A0B8RZS0 (/IMP) A0A0B8RZS0 (/IMP) G9BWQ2 (/IMP) G9BWQ2 (/IMP) P31750 (/IMP) Q8INB9 (/IMP) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
4 | P31750 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
Protein kinase C binding GO:0005080
Interacting selectively and non-covalently with protein kinase C.
|
3 | P47196 (/IPI) P47197 (/IPI) Q63484 (/IPI) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
3 | P31750 (/ISS) P47196 (/ISS) Q01314 (/ISS) |
|
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
|
2 | P31750 (/ISO) Q9WUA6 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | P31750 (/IPI) P47196 (/IPI) |
|
Protein serine/threonine/tyrosine kinase activity GO:0004712
Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
|
1 | P31750 (/ISO) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
1 | Q17941 (/IPI) |
|
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
|
1 | P31750 (/ISO) |
|
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
1 | P31750 (/ISO) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | P31750 (/EXP) |
|
Kinase activity GO:0016301
Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
|
1 | P31750 (/ISO) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P47196 (/IPI) |
|
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P31750 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | P31750 (/ISO) |
|
Nitric-oxide synthase regulator activity GO:0030235
Modulates the activity of nitric oxide synthase.
|
1 | P31750 (/ISO) |
|
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
1 | P47196 (/IPI) |
|
GTPase activating protein binding GO:0032794
Interacting selectively and non-covalently with a GTPase activating protein.
|
1 | P31750 (/ISO) |
|
Phosphatidylinositol binding GO:0035091
Interacting selectively and non-covalently with any inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
|
1 | Q8INB9 (/NAS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P31750 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P31750 (/ISO) |
|
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
|
1 | P31750 (/ISO) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | P47196 (/IPI) |
|
Protein phosphatase 2A binding GO:0051721
Interacting selectively and non-covalently with the enzyme protein phosphatase 2A.
|
1 | P31750 (/ISO) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | P31750 (/ISO) |
There are 364 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
|
114 |
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B3KVH4 (/ISS)
C1PIG3 (/ISS)
C5IJA6 (/ISS)
(104 more) |
|
Response to insulin-like growth factor stimulus GO:1990418
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
114 |
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B0LPE5 (/ISS)
B3KVH4 (/ISS)
C1PIG3 (/ISS)
C5IJA6 (/ISS)
(104 more) |
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
34 |
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31751 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
(24 more) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
33 |
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
(23 more) |
|
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
33 |
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
(23 more) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
27 |
P47197 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
Q9Y243 (/TAS)
(17 more) |
|
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
|
26 |
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
(16 more) |
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
26 |
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
(16 more) |
|
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
|
26 |
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
(16 more) |
|
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
|
26 |
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
Q9Y243 (/IDA)
(16 more) |
|
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
|
26 |
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
Q9Y243 (/IMP)
(16 more) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
16 |
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31750 (/IDA)
P47196 (/IDA)
P47197 (/IDA)
(6 more) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
13 |
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31750 (/IMP)
P31751 (/IMP)
P47196 (/IMP)
(3 more) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
12 |
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31750 (/IMP)
P31751 (/IMP)
P47196 (/IMP)
(2 more) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
12 |
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31749 (/IMP)
P31750 (/IMP)
P31751 (/IMP)
P47197 (/IMP)
(2 more) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
11 |
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31750 (/IDA)
P47196 (/IDA)
Q17941 (/IDA)
(1 more) |
|
Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
10 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
10 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
10 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
10 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
|
10 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31751 (/IMP) P47197 (/IMP) Q8UUX0 (/IMP) |
|
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
|
10 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
9 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) Q60823 (/IDA) Q60823 (/IDA) |
|
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
9 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31750 (/ISS) P47196 (/ISS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
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9 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31750 (/IMP) P47197 (/IMP) |
|
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
9 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) Q17941 (/IDA) Q9XTG7 (/IDA) |
|
Cellular protein modification process GO:0006464
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
|
8 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31751 (/TAS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31751 (/IMP) |
|
Negative regulation of long-chain fatty acid import across plasma membrane GO:0010748
Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31751 (/IMP) |
|
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31751 (/IMP) |
|
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31751 (/IMP) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
8 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P47196 (/IDA) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P47196 (/IMP) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
8 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31751 (/TAS) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P47197 (/IMP) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P47197 (/IMP) |
|
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
8 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31751 (/IMP) |
|
Mammary gland epithelial cell differentiation GO:0060644
The process in which a relatively unspecialized epithelial cell becomes a more specialized epithelial cell of the mammary gland.
|
8 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31751 (/TAS) |
|
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Regulation of glycogen biosynthetic process GO:0005979
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
7 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Nitric oxide biosynthetic process GO:0006809
The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Activation-induced cell death of T cells GO:0006924
A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
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7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
7 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) |
|
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of macroautophagy GO:0016242
Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Cell differentiation GO:0030154
The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
TOR signaling GO:0031929
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Negative regulation of fatty acid beta-oxidation GO:0031999
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of endodeoxyribonuclease activity GO:0032079
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Activation of protein kinase B activity GO:0032148
Any process that initiates the activity of the inactive enzyme protein kinase B.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
7 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) |
|
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Response to fluid shear stress GO:0034405
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
NIK/NF-kappaB signaling GO:0038061
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Anoikis GO:0043276
Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Regulation of mRNA stability GO:0043488
Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737
Any process that activates or increases the frequency, rate or extent of CDK activity.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of epidermal growth factor receptor signaling pathway GO:0045742
Any process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Negative regulation of Notch signaling pathway GO:0045746
Any process that stops, prevents, or reduces the frequency, rate or extent of the Notch signaling pathway.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Insulin-like growth factor receptor signaling pathway GO:0048009
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Cofactor metabolic process GO:0051186
The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Negative regulation of protein kinase B signaling GO:0051898
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Response to UV-A GO:0070141
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.
|
7 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) |
|
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of protein serine/threonine kinase activity GO:0071901
Any process that decreases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Establishment of protein localization to mitochondrion GO:0072655
The directed movement of a protein to the mitochondrion or a part of the mitochondrion.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Maintenance of protein location in mitochondrion GO:0072656
Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of protein kinase activity by protein phosphorylation GO:0100002
Any protein phosphorylation process that negatively_regulates protein kinase activity
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176
Any process that stops, prevents or reduces the frequency, rate or extent of an oxidative stress-induced intrinsic apoptotic signaling pathway.
|
7 | P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) P31749 (/NAS) |
|
Negative regulation of leukocyte cell-cell adhesion GO:1903038
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Positive regulation of I-kappaB phosphorylation GO:1903721
Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of lymphocyte migration GO:2000402
Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.
|
7 | P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) P31749 (/IMP) |
|
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
|
5 | P31751 (/ISS) P47197 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Intracellular protein transmembrane transport GO:0065002
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
|
5 | P31751 (/ISS) P47197 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
|
5 | P31751 (/ISS) P47197 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
4 | P31751 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
4 | P31750 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | P31750 (/IMP) P47196 (/IMP) P47197 (/IMP) Q63484 (/IMP) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
4 | P31750 (/IDA) Q60823 (/IDA) Q60823 (/IDA) Q8INB9 (/IDA) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
Positive regulation of adipose tissue development GO:1904179
Any process that activates or increases the frequency, rate or extent of adipose tissue development.
|
4 | A0A0B8RZS0 (/IMP) A0A0B8RZS0 (/IMP) G9BWQ2 (/IMP) G9BWQ2 (/IMP) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Glucose metabolic process GO:0006006
The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.
|
3 | P31750 (/IMP) Q60823 (/IMP) Q60823 (/IMP) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
3 | P47196 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
3 | Q60823 (/IDA) Q60823 (/IDA) Q8INB9 (/IDA) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
3 | P31750 (/ISS) P47196 (/ISS) Q98TY9 (/ISS) |
|
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Negative regulation of long-chain fatty acid import across plasma membrane GO:0010748
Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of mitochondrial membrane potential GO:0010918
Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Peripheral nervous system myelin maintenance GO:0032287
The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state.
|
3 | P31750 (/IMP) Q60823 (/IMP) Q60823 (/IMP) |
|
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of glycogen biosynthetic process GO:0045725
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Insulin-like growth factor receptor signaling pathway GO:0048009
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
|
3 | P31750 (/ISS) P47196 (/ISS) Q98TY9 (/ISS) |
|
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
2 | P31750 (/ISO) Q9WUA6 (/ISO) |
|
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | P31750 (/ISO) Q9WUA6 (/ISO) |
|
Determination of adult lifespan GO:0008340
The control of viability and duration in the adult phase of the life-cycle.
|
2 | Q17941 (/IMP) Q9XTG7 (/IMP) |
|
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
|
2 | Q17941 (/IGI) Q9XTG7 (/IGI) |
|
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
2 | P47196 (/ISS) Q01314 (/ISS) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | P31750 (/ISO) Q9WUA6 (/ISO) |
|
Peptidyl-threonine phosphorylation GO:0018107
The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
2 | P31750 (/ISO) Q9WUA6 (/ISO) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
2 | P31750 (/ISS) Q01314 (/ISS) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of vesicle fusion GO:0031340
Any process that activates or increases the frequency, rate or extent of vesicle fusion.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Positive regulation of fatty acid beta-oxidation GO:0032000
Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
2 | P31750 (/IMP) P47196 (/IMP) |
|
Negative regulation of RNA splicing GO:0033119
Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Glucose homeostasis GO:0042593
Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.
|
2 | P31750 (/IMP) Q8UUX0 (/IMP) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of blood vessel endothelial cell migration GO:0043536
Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels.
|
2 | P31750 (/ISO) Q9WUA6 (/ISO) |
|
Positive regulation of cell size GO:0045793
Any process that increases cell size.
|
2 | Q8INB9 (/IMP) Q9WUA6 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Positive regulation of glucose import GO:0046326
Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.
|
2 | Q60823 (/IGI) Q60823 (/IGI) |
|
Positive regulation of organ growth GO:0046622
Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.
|
2 | P31750 (/IMP) Q8INB9 (/IMP) |
|
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Response to growth hormone GO:0060416
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone stimulus. Growth hormone is a peptide hormone that binds to the growth hormone receptor and stimulates growth.
|
2 | G3X7B5 (/IDA) Q01314 (/IDA) |
|
Intracellular protein transmembrane transport GO:0065002
The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Cellular response to organic cyclic compound GO:0071407
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus.
|
2 | P47196 (/IDA) P47197 (/IDA) |
|
Cellular response to high light intensity GO:0071486
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Protein localization to plasma membrane GO:0072659
A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane.
|
2 | Q60823 (/IGI) Q60823 (/IGI) |
|
Positive regulation of protein targeting to membrane GO:0090314
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
2 | Q60823 (/IGI) Q60823 (/IGI) |
|
Retinal rod cell apoptotic process GO:0097473
Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Cellular response to insulin-like growth factor stimulus GO:1990314
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
2 | C1PIG3 (/IMP) G9BWQ1 (/IMP) |
|
Response to insulin-like growth factor stimulus GO:1990418
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus.
|
2 | G3X7B5 (/IDA) Q01314 (/IDA) |
|
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
|
1 | Q9WUA6 (/ISO) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
1 | P31750 (/IGI) |
|
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P47197 (/IEP) |
|
Maternal placenta development GO:0001893
Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
|
1 | P31750 (/IMP) |
|
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
|
1 | P47197 (/IMP) |
|
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
|
1 | P31750 (/ISO) |
|
Glycogen metabolic process GO:0005977
The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.
|
1 | P31750 (/IMP) |
|
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
|
1 | P47196 (/IMP) |
|
Glycogen biosynthetic process GO:0005978
The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues.
|
1 | P31750 (/ISO) |
|
Regulation of glycogen biosynthetic process GO:0005979
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.
|
1 | P31750 (/ISO) |
|
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
|
1 | P47196 (/IMP) |
|
Translation GO:0006412
The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.
|
1 | P31750 (/ISO) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
1 | P47196 (/IDA) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
1 | P31750 (/ISO) |
|
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
|
1 | P31750 (/ISO) |
|
Lipid metabolic process GO:0006629
The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.
|
1 | Q8INB9 (/IMP) |
|
Activation-induced cell death of T cells GO:0006924
A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
|
1 | P31750 (/ISO) |
|
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | Q17941 (/IGI) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
1 | P31750 (/IDA) |
|
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
1 | P47197 (/IEP) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | P47196 (/IDA) |
|
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
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1 | P31750 (/ISO) |
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Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | Q8INB9 (/IMP) |
|
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
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1 | P31750 (/TAS) |
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Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
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1 | P47196 (/IDA) |
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Epidermal growth factor receptor signaling pathway GO:0007173
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
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1 | P31750 (/ISO) |
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I-kappaB kinase/NF-kappaB signaling GO:0007249
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
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1 | P31750 (/ISO) |
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Germ cell development GO:0007281
The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.
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1 | P31750 (/IDA) |
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Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
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1 | Q8INB9 (/IMP) |
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Epithelial cell migration, open tracheal system GO:0007427
The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster.
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1 | Q8INB9 (/IMP) |
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Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
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1 | Q8INB9 (/IMP) |
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Somatic muscle development GO:0007525
The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle.
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1 | Q8INB9 (/IMP) |
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Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
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1 | P47196 (/IDA) |
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Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
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1 | P31750 (/ISO) |
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Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
|
1 | Q8INB9 (/IMP) |
|
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
|
1 | Q17941 (/IGI) |
|
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
|
1 | Q8INB9 (/IGI) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
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1 | Q8INB9 (/IGI) |
|
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
|
1 | P31751 (/TAS) |
|
Chitin-based embryonic cuticle biosynthetic process GO:0008362
Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster.
|
1 | Q8INB9 (/IGI) |
|
Apoptotic mitochondrial changes GO:0008637
The morphological and physiological alterations undergone by mitochondria during apoptosis.
|
1 | P31750 (/IDA) |
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Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P31750 (/IDA) |
|
Positive regulation of signal transduction GO:0009967
Any process that activates or increases the frequency, rate or extent of signal transduction.
|
1 | P47197 (/IMP) |
|
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
|
1 | P31750 (/IDA) |
|
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
|
1 | P31750 (/ISO) |
|
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | P31750 (/IDA) |
|
Positive regulation of fibroblast migration GO:0010763
Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium.
|
1 | P31750 (/IMP) |
|
Positive regulation of sodium ion transport GO:0010765
Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P31750 (/IDA) |
|
Positive regulation of lipid storage GO:0010884
Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
|
1 | Q8INB9 (/IGI) |
|
Positive regulation of lipid storage GO:0010884
Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
|
1 | Q8INB9 (/IMP) |
|
Negative regulation of triglyceride catabolic process GO:0010897
Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
|
1 | Q8INB9 (/IMP) |
|
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
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1 | P31750 (/ISO) |
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Regulation of neuron projection development GO:0010975
Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P31750 (/IDA) |
|
Phosphatidylinositol 3-kinase signaling GO:0014065
A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
|
1 | P31750 (/ISO) |
|
Response to muscle activity GO:0014850
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus.
|
1 | P47197 (/IEP) |
|
Phosphorylation GO:0016310
The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
|
1 | P31750 (/ISO) |
|
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
|
1 | P31750 (/IDA) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | P31750 (/IMP) |
|
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
|
1 | P47196 (/IDA) |
|
Spinal cord development GO:0021510
The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues.
|
1 | P31750 (/ISO) |
|
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
|
1 | P47196 (/IDA) |
|
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
|
1 | P31750 (/ISO) |
|
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
|
1 | P31750 (/IDA) |
|
Hyaluronan metabolic process GO:0030212
The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
|
1 | P47196 (/IEP) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q8INB9 (/IMP) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | P31750 (/ISO) |
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Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | P31750 (/ISO) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P31751 (/IDA) |
|
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
|
1 | P47197 (/IMP) |
|
Dendrite regeneration GO:0031104
The regrowth of dendrites in response to their loss or damage.
|
1 | Q8INB9 (/IMP) |
|
Negative regulation of protein ubiquitination GO:0031397
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.
|
1 | P31750 (/ISO) |
|
Regulation of myelination GO:0031641
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
|
1 | P31750 (/IMP) |
|
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
|
1 | P31750 (/IDA) |
|
Response to nutrient levels GO:0031667
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | P47197 (/IEP) |
|
Negative regulation of fatty acid beta-oxidation GO:0031999
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.
|
1 | P31750 (/ISO) |
|
Positive regulation of fatty acid beta-oxidation GO:0032000
Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.
|
1 | P31751 (/IMP) |
|
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
|
1 | Q9WUA6 (/IMP) |
|
Positive regulation of endodeoxyribonuclease activity GO:0032079
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.
|
1 | P31750 (/ISO) |
|
Negative regulation of protein binding GO:0032091
Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding.
|
1 | P31750 (/ISO) |
|
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
|
1 | P31750 (/IDA) |
|
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
1 | P47196 (/IMP) |
|
Positive regulation of cellular protein metabolic process GO:0032270
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.
|
1 | P31750 (/ISO) |
|
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
|
1 | P31750 (/IMP) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | P47197 (/IDA) |
|
Response to insulin GO:0032868
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | P47197 (/IEP) |
|
Cellular response to hormone stimulus GO:0032870
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
|
1 | P47197 (/IEP) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | P31750 (/IDA) |
|
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | P31750 (/ISO) |
|
Negative regulation of RNA splicing GO:0033119
Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing.
|
1 | P47197 (/IMP) |
|
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
1 | P47197 (/IMP) |
|
Response to fluid shear stress GO:0034405
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluid shear stress stimulus. Fluid shear stress is the force acting on an object in a system where the fluid is moving across a solid surface.
|
1 | P31750 (/ISO) |
|
Cellular response to reactive oxygen species GO:0034614
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.
|
1 | P31750 (/ISO) |
|
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
|
1 | Q8INB9 (/IMP) |
|
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | Q8INB9 (/IMP) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | Q8INB9 (/IGI) |
|
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
|
1 | P31750 (/ISO) |
|
Interleukin-18-mediated signaling pathway GO:0035655
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P31750 (/ISO) |
|
Cellular response to vascular endothelial growth factor stimulus GO:0035924
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.
|
1 | P31750 (/IDA) |
|
Cellular response to decreased oxygen levels GO:0036294
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.
|
1 | P31750 (/IDA) |
|
NIK/NF-kappaB signaling GO:0038061
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).
|
1 | P31750 (/ISO) |
|
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
|
1 | Q8INB9 (/IMP) |
|
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
|
1 | Q8INB9 (/IGI) |
|
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
|
1 | Q8INB9 (/IMP) |
|
Intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | Q17941 (/IMP) |
|
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
|
1 | P31750 (/IDA) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P47196 (/IMP) |
|
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | P31750 (/ISO) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q98TY9 (/ISS) |
|
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | P47196 (/TAS) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | P31750 (/IDA) |
|
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | P47197 (/IMP) |
|
Protein kinase B signaling GO:0043491
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.
|
1 | P31750 (/IGI) |
|
Fat cell differentiation GO:0045444
The process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat.
|
1 | P31751 (/TAS) |
|
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
|
1 | P31750 (/ISO) |
|
Negative regulation of neuron differentiation GO:0045665
Any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.
|
1 | M4MD44 (/IMP) |
|
Positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737
Any process that activates or increases the frequency, rate or extent of CDK activity.
|
1 | P31750 (/ISO) |
|
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
|
1 | Q9WUA6 (/IMP) |
|
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
|
1 | P47196 (/IDA) |
|
Negative regulation of cell size GO:0045792
Any process that reduces cell size.
|
1 | P31750 (/ISO) |
|
Negative regulation of proteolysis GO:0045861
Any process that stops, prevents, or reduces the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
|
1 | P31750 (/ISO) |
|
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
1 | Q8INB9 (/IMP) |
|
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | P31750 (/ISO) |
|
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
|
1 | P47196 (/IMP) |
|
Positive regulation of vasoconstriction GO:0045907
Any process that activates or increases the frequency, rate or extent of vasoconstriction.
|
1 | P31750 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P31750 (/IGI) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | P47197 (/IMP) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | P47196 (/IDA) |
|
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
|
1 | P31750 (/ISO) |
|
Positive regulation of lipid biosynthetic process GO:0046889
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
|
1 | P31750 (/ISO) |
|
Insulin-like growth factor receptor signaling pathway GO:0048009
The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.
|
1 | P31750 (/ISO) |
|
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8INB9 (/IGI) |
|
Vascular endothelial growth factor receptor signaling pathway GO:0048010
Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q8INB9 (/IMP) |
|
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
|
1 | Q8INB9 (/IMP) |
|
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
|
1 | P31750 (/ISO) |
|
Positive regulation of axon regeneration GO:0048680
Any process that activates, maintains or increases the rate of axon regeneration.
|
1 | Q8INB9 (/IMP) |
|
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
1 | Q9WUA6 (/IMP) |
|
Homeostasis of number of cells within a tissue GO:0048873
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue.
|
1 | Q9WUA6 (/IMP) |
|
Regulation of dendrite development GO:0050773
Any process that modulates the frequency, rate or extent of dendrite development.
|
1 | Q8INB9 (/IMP) |
|
Positive regulation of positive chemotaxis GO:0050927
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.
|
1 | P47197 (/IDA) |
|
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
|
1 | P31750 (/ISO) |
|
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | P31750 (/ISO) |
|
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
|
1 | P31750 (/IGI) |
|
Long-term synaptic depression GO:0060292
A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse.
|
1 | Q8INB9 (/IMP) |
|
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
|
1 | Q8UUX0 (/IMP) |
|
Glycogen cell differentiation involved in embryonic placenta development GO:0060709
The process in which a relatively unspecialized cell acquires specialized features of a glycogen cell of the placenta. A glycogen cell is a vacuolated glycogen-rich cell that appears in compact cell islets of the spongiotrophoblast layer.
|
1 | P31750 (/IMP) |
|
Labyrinthine layer blood vessel development GO:0060716
The process whose specific outcome is the progression of a blood vessel of the labyrinthine layer of the placenta over time, from its formation to the mature structure. The embryonic vessels grow through the layer to come in close contact with the maternal blood supply.
|
1 | P31750 (/IMP) |
|
Response to UV-A GO:0070141
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm.
|
1 | P31750 (/ISO) |
|
Regulation of cell cycle arrest GO:0071156
Any process that modulates the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
1 | P31751 (/TAS) |
|
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
1 | P47196 (/IDA) |
|
Cellular response to mechanical stimulus GO:0071260
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
|
1 | P31750 (/ISO) |
|
Cellular response to cadmium ion GO:0071276
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
|
1 | P31750 (/ISO) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | P31750 (/IDA) |
|
Cellular response to tumor necrosis factor GO:0071356
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
|
1 | P31750 (/ISO) |
|
Cellular response to growth factor stimulus GO:0071363
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.
|
1 | P31750 (/IDA) |
|
Cellular response to epidermal growth factor stimulus GO:0071364
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epidermal growth factor stimulus.
|
1 | P31750 (/IDA) |
|
Cellular response to prostaglandin E stimulus GO:0071380
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prostagladin E stimulus.
|
1 | P31750 (/IDA) |
|
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P47196 (/IDA) |
|
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
|
1 | P31750 (/ISO) |
|
Establishment of protein localization to mitochondrion GO:0072655
The directed movement of a protein to the mitochondrion or a part of the mitochondrion.
|
1 | P31750 (/ISO) |
|
Maintenance of protein location in mitochondrion GO:0072656
Any process in which a protein is maintained in a specific location in a mitochondrion, and is prevented from moving elsewhere.
|
1 | P31750 (/ISO) |
|
Positive regulation of cell migration involved in sprouting angiogenesis GO:0090050
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.
|
1 | Q9WUA6 (/ISO) |
|
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
|
1 | P31750 (/IDA) |
|
Negative regulation of peptide hormone secretion GO:0090278
Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.
|
1 | Q8INB9 (/IMP) |
|
Cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
|
1 | P31750 (/IDA) |
|
Execution phase of apoptosis GO:0097194
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
|
1 | P31750 (/IDA) |
|
Cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxidized lipoprotein particle stimulus.
|
1 | P31750 (/ISO) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
1 | P31750 (/ISO) |
|
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
|
1 | P31750 (/ISO) |
|
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
1 | Q8INB9 (/IGI) |
|
Cellular response to peptide GO:1901653
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.
|
1 | P31750 (/IDA) |
|
Response to salt GO:1902074
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.
|
1 | Q17941 (/IGI) |
|
Negative regulation of leukocyte cell-cell adhesion GO:1903038
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte cell-cell adhesion.
|
1 | P31750 (/ISO) |
|
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
|
1 | P31750 (/ISO) |
|
Positive regulation of I-kappaB phosphorylation GO:1903721
Any process that activates or increases the frequency, rate or extent of I-kappaB phosphorylation.
|
1 | P31750 (/ISO) |
|
Negative regulation of TORC1 signaling GO:1904262
Any process that stops, prevents or reduces the frequency, rate or extent of TORC1 signaling.
|
1 | Q8INB9 (/IGI) |
|
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
|
1 | Q8INB9 (/IMP) |
|
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
|
1 | Q9WUA6 (/ISO) |
|
Positive regulation of artery morphogenesis GO:1905653
Any process that activates or increases the frequency, rate or extent of artery morphogenesis.
|
1 | Q9WUA6 (/IMP) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | P47196 (/IDA) |
|
Cellular response to nerve growth factor stimulus GO:1990090
A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus.
|
1 | P31750 (/ISO) |
|
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
|
1 | P31750 (/IMP) |
|
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
|
1 | Q98TY9 (/ISS) |
|
Positive regulation of cell motility GO:2000147
Any process that activates or increases the frequency, rate or extent of cell motility.
|
1 | P31751 (/IMP) |
|
Negative regulation of lymphocyte migration GO:2000402
Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration.
|
1 | P31750 (/ISO) |
|
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
|
1 | Q9WUA6 (/ISO) |
There are 43 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
37 |
E1B9D1 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
F1MYJ4 (/IDA)
(27 more) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
22 |
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
C1PIG3 (/IDA)
G9BWQ1 (/IDA)
M0R0P9 (/IDA)
(12 more) |
|
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
14 |
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
B0LPE5 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
(4 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
13 |
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31750 (/TAS)
P31751 (/TAS)
P47196 (/TAS)
(3 more) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
12 |
M0R0P9 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31751 (/IDA)
P47196 (/IDA)
(2 more) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
12 |
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31750 (/TAS)
P31751 (/TAS)
Q60823 (/TAS)
(2 more) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
11 |
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31749 (/TAS)
P31751 (/TAS)
P47196 (/TAS)
P47197 (/TAS)
(1 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
11 |
C1PIG3 (/IDA)
G9BWQ1 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31749 (/IDA)
P31750 (/IDA)
(1 more) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
9 | P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) P31749 (/ISS) Q01314 (/ISS) Q98TY9 (/ISS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
9 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31750 (/IDA) P31751 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31751 (/TAS) |
|
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
|
8 | P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P31749 (/IDA) P47197 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
7 | P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) P31749 (/TAS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
6 | P31751 (/ISS) P47196 (/ISS) Q01314 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
5 | P31751 (/ISS) P47197 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
5 | P31751 (/ISS) P47197 (/ISS) Q6IP76 (/ISS) Q7ZX15 (/ISS) Q7ZX15 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) Q9WUA6 (/ISO) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
3 | P31750 (/ISO) Q60823 (/ISO) Q60823 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
3 | M0R0P9 (/IDA) P31751 (/IDA) P47197 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | P47196 (/ISS) Q01314 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | P31750 (/IDA) P47197 (/IDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Ruffle membrane GO:0032587
The portion of the plasma membrane surrounding a ruffle.
|
2 | Q60823 (/IMP) Q60823 (/IMP) |
|
Insulin-responsive compartment GO:0032593
A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | Q17941 (/IDA) Q8INB9 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
2 | Q60823 (/ISO) Q60823 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P31750 (/ISO) |
|
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
|
1 | P31750 (/IDA) |
|
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
1 | P31750 (/IDA) |
|
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | Q8INB9 (/IDA) |
|
Cytoplasmic side of plasma membrane GO:0009898
The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q17941 (/IDA) |
|
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
|
1 | P31750 (/ISO) |
|
Sarcoplasmic reticulum GO:0016529
A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage.
|
1 | P47197 (/IDA) |
|
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q17941 (/IDA) |
|
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q17941 (/IDA) |
|
Insulin-responsive compartment GO:0032593
A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.
|
1 | P47197 (/IDA) |
|
Ciliary basal body GO:0036064
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.
|
1 | P31750 (/IDA) |
