The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 31: Mitogen-activated protein kinase kinase kinase kin...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 P70218 (/IPI) Q12851 (/IPI) Q12851 (/IPI) Q8IVH8 (/IPI) Q92918 (/IPI) Q99JP0 (/IPI) Q9Y4K4 (/IPI)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
6 A0A0B4LFQ3 (/IGI) A0A0B4LFV0 (/IGI) A0A0B4LGY8 (/IGI) A1ZBH7 (/IGI) A1ZBH8 (/IGI) Q8SYA1 (/IGI)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
6 P70218 (/IDA) Q12851 (/IDA) Q12851 (/IDA) Q8IVH8 (/IDA) Q92918 (/IDA) Q9Y4K4 (/IDA)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
6 P70218 (/IDA) Q12851 (/IDA) Q12851 (/IDA) Q8IVH8 (/IDA) Q92918 (/IDA) Q9Y4K4 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
4 P70218 (/ISO) Q61161 (/ISO) Q8BPM2 (/ISO) Q99JP0 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 P70218 (/ISO) Q61161 (/ISO) Q8BPM2 (/ISO) Q99JP0 (/ISO)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
4 Q61161 (/ISS) Q8BPM2 (/ISS) Q924I2 (/ISS) Q99JP0 (/ISS)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
3 Q8IVH8 (/TAS) Q92918 (/TAS) Q9Y4K4 (/TAS)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 Q8BPM2 (/ISS) Q924I2 (/ISS) Q99JP0 (/ISS)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
2 Q12851 (/IPI) Q12851 (/IPI)
MAP kinase kinase kinase kinase activity GO:0008349
Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
1 Q92918 (/IDA)
MAP kinase kinase kinase kinase activity GO:0008349
Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli.
1 P70218 (/ISO)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q924I2 (/IPI)
SH3 domain binding GO:0017124
Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins.
1 Q99JP0 (/ISO)
Mitogen-activated protein kinase kinase kinase binding GO:0031435
Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase.
1 Q61161 (/ISO)

There are 46 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 P70218 (/IDA) Q12851 (/IDA) Q12851 (/IDA) Q8IVH8 (/IDA) Q92918 (/IDA) Q9Y4K4 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
6 A0A0B4LFQ3 (/IGI) A0A0B4LFV0 (/IGI) A0A0B4LGY8 (/IGI) A1ZBH7 (/IGI) A1ZBH8 (/IGI) Q8SYA1 (/IGI)
Apoptotic process GO:0006915
A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
6 A0A0B4LFQ3 (/IDA) A0A0B4LFV0 (/IDA) A0A0B4LGY8 (/IDA) A1ZBH7 (/IDA) A1ZBH8 (/IDA) Q8SYA1 (/IDA)
Golgi organization GO:0007030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.
6 A0A0B4LFQ3 (/IMP) A0A0B4LFV0 (/IMP) A0A0B4LGY8 (/IMP) A1ZBH7 (/IMP) A1ZBH8 (/IMP) Q8SYA1 (/IMP)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
6 A0A0B4LFQ3 (/IDA) A0A0B4LFV0 (/IDA) A0A0B4LGY8 (/IDA) A1ZBH7 (/IDA) A1ZBH8 (/IDA) Q8SYA1 (/IDA)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
6 A0A0B4LFQ3 (/IMP) A0A0B4LFV0 (/IMP) A0A0B4LGY8 (/IMP) A1ZBH7 (/IMP) A1ZBH8 (/IMP) Q8SYA1 (/IMP)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
6 A0A0B4LFQ3 (/IGI) A0A0B4LFV0 (/IGI) A0A0B4LGY8 (/IGI) A1ZBH7 (/IGI) A1ZBH8 (/IGI) Q8SYA1 (/IGI)
Regulation of growth rate GO:0040009
Any process that modulates the rate of growth of all or part of an organism.
6 A0A0B4LFQ3 (/IMP) A0A0B4LFV0 (/IMP) A0A0B4LGY8 (/IMP) A1ZBH7 (/IMP) A1ZBH8 (/IMP) Q8SYA1 (/IMP)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
6 A0A0B4LFQ3 (/IGI) A0A0B4LFV0 (/IGI) A0A0B4LGY8 (/IGI) A1ZBH7 (/IGI) A1ZBH8 (/IGI) Q8SYA1 (/IGI)
Behavioral response to ethanol GO:0048149
Any process that results in a change in the behavior of an organism as a result of an ethanol stimulus.
6 A0A0B4LFQ3 (/IMP) A0A0B4LFV0 (/IMP) A0A0B4LGY8 (/IMP) A1ZBH7 (/IMP) A1ZBH8 (/IMP) Q8SYA1 (/IMP)
Triglyceride homeostasis GO:0070328
Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
6 A0A0B4LFQ3 (/IMP) A0A0B4LFV0 (/IMP) A0A0B4LGY8 (/IMP) A1ZBH7 (/IMP) A1ZBH8 (/IMP) Q8SYA1 (/IMP)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
5 P70218 (/IDA) Q12851 (/IDA) Q12851 (/IDA) Q8IVH8 (/IDA) Q9Y4K4 (/IDA)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
4 P70218 (/ISO) Q61161 (/ISO) Q8BPM2 (/ISO) Q99JP0 (/ISO)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
4 Q61161 (/ISS) Q8BPM2 (/ISS) Q924I2 (/ISS) Q99JP0 (/ISS)
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
3 Q61161 (/ISS) Q924I2 (/ISS) Q99JP0 (/ISS)
JNK cascade GO:0007254
An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
3 Q12851 (/TAS) Q12851 (/TAS) Q8IVH8 (/TAS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
3 Q12851 (/IDA) Q12851 (/IDA) Q92918 (/IDA)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
3 Q61161 (/ISO) Q8BPM2 (/ISO) Q99JP0 (/ISO)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
2 Q12851 (/TAS) Q12851 (/TAS)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
2 P70218 (/ISO) Q61161 (/ISO)
Activation of JUN kinase activity GO:0007257
The initiation of the activity of the inactive enzyme JUN kinase (JNK).
2 Q92918 (/TAS) Q9Y4K4 (/TAS)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
2 Q924I2 (/ISS) Q99JP0 (/ISS)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
2 Q12851 (/IDA) Q12851 (/IDA)
Activation of MAPKKK activity GO:0000185
Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK).
1 Q92918 (/IC)
Vesicle targeting GO:0006903
The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo.
1 Q61161 (/IDA)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q92918 (/IMP)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P70218 (/ISO)
Cell population proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 P70218 (/ISS)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q8IVH8 (/IDA)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q99JP0 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 Q92918 (/IDA)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 P70218 (/ISO)
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
1 P70218 (/ISS)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q8IVH8 (/IDA)
Response to tumor necrosis factor GO:0034612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
1 Q99JP0 (/ISO)
Positive regulation of hippo signaling GO:0035332
Any process that activates or increases the frequency, rate or extent of hippo signaling.
1 A1ZBH7 (/IGI)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 A1ZBH7 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
1 A1ZBH7 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 A1ZBH7 (/IMP)
Positive regulation of JNK cascade GO:0046330
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q61161 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 Q92918 (/IDA)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P70218 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 P70218 (/ISS)
Positive regulation of TORC1 signaling GO:1904263
Any process that activates or increases the frequency, rate or extent of TORC1 signaling.
1 A1ZBH7 (/IGI)
Cellular response to phorbol 13-acetate 12-myristate GO:1904628
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus.
1 Q92918 (/IDA)
Cellular response to phorbol 13-acetate 12-myristate GO:1904628
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phorbol 13-acetate 12-myristate stimulus.
1 P70218 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
2 Q12851 (/TAS) Q12851 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Y4K4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BPM2 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8BPM2 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A1ZBH7 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q92918 (/HDA)
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