The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 270: Guanylate cyclase
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
10 | P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) Q6VVW5 (/IDA) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
10 | P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) Q6VVW5 (/IDA) |
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
9 | P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
9 | P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) |
|
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
|
9 | P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) |
|
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
9 | P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) P20594 (/IPI) |
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
1 | Q6VVW5 (/ISO) |
|
Guanylate cyclase activity GO:0004383
Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate.
|
1 | P55202 (/ISS) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
1 | Q6VVW5 (/ISO) |
|
Natriuretic peptide receptor activity GO:0016941
Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity.
|
1 | P55202 (/ISS) |
|
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
|
1 | P16067 (/IMP) |
|
Peptide hormone binding GO:0017046
Interacting selectively and non-covalently with any peptide with hormonal activity in animals.
|
1 | Q6VVW5 (/ISO) |
|
Hormone binding GO:0042562
Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone.
|
1 | Q6VVW5 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q6VVW5 (/IPI) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
|
9 | P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
9 | P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
9 | P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) P20594 (/IMP) |
|
Regulation of blood pressure GO:0008217
Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.
|
9 | P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) |
|
Cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.
|
9 | P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) P20594 (/IEP) |
|
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
|
9 | P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | P16067 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS) |
|
Cardiac muscle cell proliferation GO:0060038
The expansion of a cardiac muscle cell population by cell division.
|
2 | A0A0G2KGK2 (/IMP) A0A2R8QJI9 (/IMP) |
|
CGMP biosynthetic process GO:0006182
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate.
|
1 | Q6VVW5 (/ISO) |
|
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q6VVW5 (/ISO) |
|
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
1 | P16067 (/IDA) |
|
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
|
1 | Q6VVW5 (/ISO) |
|
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
|
1 | P16067 (/IDA) |
|
CGMP-mediated signaling GO:0019934
Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell.
|
1 | Q6VVW5 (/ISO) |
|
Reproductive process GO:0022414
A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.
|
1 | Q6VVW5 (/IMP) |
|
Negative regulation of meiotic cell cycle GO:0051447
Any process that stops, prevents or reduces the rate or extent of progression through the meiotic cell cycle.
|
1 | Q6VVW5 (/IMP) |
|
Bone development GO:0060348
The process whose specific outcome is the progression of bone over time, from its formation to the mature structure. Bone is the hard skeletal connective tissue consisting of both mineral and cellular components.
|
1 | Q6VVW5 (/IMP) |
|
Negative regulation of oocyte maturation GO:1900194
Any process that stops, prevents or reduces the frequency, rate or extent of oocyte maturation.
|
1 | Q6VVW5 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
10 | P16067 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
10 | P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) P20594 (/TAS) Q6VVW5 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
9 | P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) P20594 (/IDA) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P16067 (/ISS) P55202 (/ISS) Q6VVW5 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P55202 (/ISS) Q6VVW5 (/ISS) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q6VVW5 (/ISO) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q6VVW5 (/ISO) |
