The process of introducing a phosphate group on to a protein.

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

The binding of a cell to the extracellular matrix via adhesion molecules.

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

The multiplication or reproduction of cells, resulting in the expansion of a cell population.

Any process that activates or increases the frequency, rate or extent of signal transduction.

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a cell junction.

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

The adhesion of one platelet to one or more other platelets via adhesion molecules.

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that activates or increases the rate or extent of cell proliferation.

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

The binding of a cell to the extracellular matrix via adhesion molecules.

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

Any process that modulates the frequency, rate, extent or direction of cell growth.

Any process that modulates the frequency, rate, extent or direction of cell growth.

The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.

Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.

The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries.

The process of introducing a phosphate group on to a protein.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.

A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane.

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing.

An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).

An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469).

Any process that activates or increases the rate or extent of cell proliferation.

Any process that activates or increases the frequency, rate or extent of signal transduction.

Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.

Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.

Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.

The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.

Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.

The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.

The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure.

The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.

Any process that activates or increases the frequency, rate or extent of cell migration.

Any process that activates or increases the frequency, rate or extent of cell migration.

Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity.

The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.

The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.

Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.

A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.

The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.

Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

Any process that activates or increases the frequency, rate or extent of MAP kinase activity.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.

Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.

Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.

Any process that activates or increases the frequency, rate or extent of axon extension.

Any process that activates or increases the frequency, rate or extent of axon extension.

Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.

Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.

Any process that stops, prevents or reduces the rate or extent of smooth muscle cell proliferation.

The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.

Any process that activates or increases the frequency, rate or extent of axonogenesis.

Any process that activates or increases the frequency, rate or extent of axonogenesis.

Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.

Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis.

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.

Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.

Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.

Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.

Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.

Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation.

The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.

The progression of an endothelial cell over time, from its formation to the mature structure.

The progression of an endothelial cell over time, from its formation to the mature structure.

The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart.

The process of introducing a phosphate group on to a protein.

The process of introducing a phosphate group on to a protein.

A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.

A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.

The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.

Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.

The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.

The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).

Formation of myofibrils, the repeating units of striated muscle.

The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.

The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.

Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.

Any process that activates or increases the frequency, rate or extent of smooth muscle contraction.

The cellular homeostatic process that preserves a muscle cell in a stable functional or structural state.

The process in which the anatomical structures of hermaphrodite genitalia are generated and organized.

The process in which the anatomical structures of hermaphrodite genitalia are generated and organized.

The process whose specific outcome is the progression of a striated muscle cell over time, from its formation to the mature structure. Striated muscle cells contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.

The process whose specific outcome is the progression of a cardiac muscle cell over time, from its formation to the mature state.

The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.

The multicellular organismal process in which the heart decreases in volume in a characteristic way to propel blood through the body.

Any process that activates or increases the frequency, rate or extent of ovulation, the release of a mature ovum/oocyte from an ovary.

Any process that increases the rate, frequency or extent of myofibril assembly by organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.

Any process that activates or increases the frequency, rate or extent of distal tip cell migration.

Any process that activates or increases the frequency, rate or extent of cellular protein localization. Cellular protein localization is any process in which a protein is transported to, and/or maintained in, a specific location and encompasses movement within the cell, from within the cell to the cell surface, or from one location to another at the surface of a cell.

Any process that activates or increases the frequency, rate or extent of myosin II filament organization.

Any process that activates or increases the frequency, rate or extent of establishment of protein localization.

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

That part of the nuclear content other than the chromosomes or the nucleolus.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

That part of the nuclear content other than the chromosomes or the nucleolus.

All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.

A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.

A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.

Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.

Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix.

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.

Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.

Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.

A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.

A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.

The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.

Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.

The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.

The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.

A vinculin-containing myofibril attachment structure of striated muscle that connects sarcomeres to the extracellular matrix. In nematode body wall muscle, the dense body performs the dual role of Z-disk and costamere.