The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transferase(Phosphotransferase) domain 1
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 179: MAP kinase-activated protein kinase 5 isoform X1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
3 O54992 (/IDA) Q8IW41 (/IDA) Q8IW41 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
3 O54992 (/IDA) Q8IW41 (/IDA) Q8IW41 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 O54992 (/IPI) Q8IW41 (/IPI) Q8IW41 (/IPI)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q8IW41 (/EXP) Q8IW41 (/EXP)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
2 Q8IW41 (/TAS) Q8IW41 (/TAS)
MAP kinase kinase activity GO:0004708
Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
2 Q8IW41 (/TAS) Q8IW41 (/TAS)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
2 O54992 (/IPI) Q965G5 (/IPI)
P53 binding GO:0002039
Interacting selectively and non-covalently with one of the p53 family of proteins.
1 O54992 (/ISO)
Protein kinase activity GO:0004672
Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
1 O54992 (/IDA)
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
1 O54992 (/ISO)

There are 32 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
2 Q8IW41 (/IDA) Q8IW41 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
2 Q8IW41 (/TAS) Q8IW41 (/TAS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
2 Q8IW41 (/IDA) Q8IW41 (/IDA)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
2 Q8IW41 (/ISS) Q8IW41 (/ISS)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
2 Q8IW41 (/IMP) Q8IW41 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
2 Q8IW41 (/IDA) Q8IW41 (/IDA)
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
2 Q8IW41 (/IMP) Q8IW41 (/IMP)
Stress-induced premature senescence GO:0090400
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
2 Q8IW41 (/IDA) Q8IW41 (/IDA)
Regulation of signal transduction by p53 class mediator GO:1901796
Any process that modulates the frequency, rate or extent of signal transduction by p53 class mediator.
2 Q8IW41 (/TAS) Q8IW41 (/TAS)
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
2 Q8IW41 (/IMP) Q8IW41 (/IMP)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 O54992 (/ISO)
Regulation of translation GO:0006417
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
1 O54992 (/ISS)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 O54992 (/IMP)
Ras protein signal transduction GO:0007265
A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state.
1 O54992 (/ISO)
Negative regulation of TOR signaling GO:0032007
Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling.
1 O54992 (/IDA)
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
1 O54992 (/ISO)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
1 Q965G5 (/IGI)
Behavioral response to nicotine GO:0035095
Any process that results in a change in the behavior of an organism as a result of a nicotine stimulus.
1 Q965G5 (/IMP)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 O54992 (/ISO)
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
1 O54992 (/ISS)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
1 Q965G5 (/IMP)
Regulation of axon extension involved in axon guidance GO:0048841
Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance.
1 Q965G5 (/IGI)
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
1 O54992 (/ISO)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 O54992 (/IGI)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
1 O54992 (/IMP)
Stress-induced premature senescence GO:0090400
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
1 O54992 (/IMP)
Stress-induced premature senescence GO:0090400
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.
1 O54992 (/ISO)
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
1 O54992 (/ISO)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
1 Q965G5 (/IGI)
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
1 Q965G5 (/IMP)
Regulation of 3'-UTR-mediated mRNA stabilization GO:1905868
Any process that modulates the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.
1 Q965G5 (/IGI)
Positive regulation of 3'-UTR-mediated mRNA stabilization GO:1905870
Any process that activates or increases the frequency, rate or extent of 3'-UTR-mediated mRNA stabilization.
1 Q965G5 (/IMP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
4 Q8IW41 (/IDA) Q8IW41 (/IDA) R4GN33 (/IDA) R4GN33 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q8IW41 (/IDA) Q8IW41 (/IDA) R4GN33 (/IDA) R4GN33 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 O54992 (/IDA) Q965G5 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q8IW41 (/TAS) Q8IW41 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 O54992 (/IDA) Q965G5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8IW41 (/TAS) Q8IW41 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 O54992 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O54992 (/ISO)
Septin cytoskeleton GO:0032156
The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.
1 O54992 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O54992 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q965G5 (/IDA)
CATH-Gene3D is a Global Biodata Core Resource Learn more...