The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Transferase(Phosphotransferase) domain 1
".
FunFam 148: Serine/threonine-protein kinase Nek7
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 22 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
17 |
A2BD05 (/ISS)
A2BD05 (/ISS)
P59895 (/ISS)
P59895 (/ISS)
Q8TDX7 (/ISS)
Q8TDX7 (/ISS)
Q8TDX7 (/ISS)
Q8TDX7 (/ISS)
Q8TDX7 (/ISS)
Q8TDX7 (/ISS)
(7 more) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
5 | A2BD05 (/ISS) A2BD05 (/ISS) P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
3 | P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
3 | D3ZBE5 (/IDA) Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q9ES74 (/IPI) Q9HC98 (/IPI) Q9HC98 (/IPI) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
3 | P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
2 | Q9HC98 (/IPI) Q9HC98 (/IPI) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q9ES70 (/ISO) Q9ES74 (/ISO) |
|
Protein serine/threonine kinase activity GO:0004674
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
|
2 | Q9HC98 (/TAS) Q9HC98 (/TAS) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
2 | Q9HC98 (/IPI) Q9HC98 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
2 | Q9HC98 (/IPI) Q9HC98 (/IPI) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
2 | Q9HC98 (/IPI) Q9HC98 (/IPI) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
2 | Q9HC98 (/IPI) Q9HC98 (/IPI) |
|
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | Q9ES70 (/ISO) |
|
Transcription corepressor binding GO:0001222
Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery.
|
1 | Q9ES70 (/ISO) |
|
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
|
1 | Q9ES70 (/ISO) |
|
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
1 | Q9ES70 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q9ES70 (/ISO) |
|
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
|
1 | Q9ES70 (/ISO) |
|
Activating transcription factor binding GO:0033613
Interacting selectively and non-covalently with an activating transcription factor, any protein whose activity is required to initiate or upregulate transcription.
|
1 | Q9ES70 (/ISO) |
There are 28 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
13 |
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
(3 more) |
|
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
|
13 |
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
(3 more) |
|
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
|
13 |
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
Q8TDX7 (/TAS)
(3 more) |
|
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
11 |
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
(1 more) |
|
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
11 |
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
(1 more) |
|
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
|
11 |
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
Q8TDX7 (/IMP)
(1 more) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
7 | A2BD05 (/ISS) A2BD05 (/ISS) D3ZBE5 (/ISS) P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) Q9ES74 (/ISS) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
5 | A2BD05 (/ISS) A2BD05 (/ISS) P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
3 | P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) |
|
Regulation of mitotic metaphase/anaphase transition GO:0030071
Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
|
3 | P59895 (/ISS) P59895 (/ISS) Q9ES70 (/ISS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
2 | Q9ES70 (/ISO) Q9ES74 (/ISO) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Mitotic nuclear envelope disassembly GO:0007077
The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs.
|
2 | Q9HC98 (/TAS) Q9HC98 (/TAS) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Regulation of mitotic metaphase/anaphase transition GO:0030071
Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
|
2 | Q9HC98 (/HMP) Q9HC98 (/HMP) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Regulation of cellular senescence GO:2000772
Any process that modulates the frequency, rate or extent of cellular senescence.
|
2 | Q9HC98 (/TAS) Q9HC98 (/TAS) |
|
Chromosome segregation GO:0007059
The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles.
|
1 | Q9ES70 (/ISO) |
|
Gonad development GO:0008406
The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones.
|
1 | G5EFM9 (/IGI) |
|
Peptidyl-serine phosphorylation GO:0018105
The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
|
1 | Q9ES70 (/ISO) |
|
Regulation of mitotic metaphase/anaphase transition GO:0030071
Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
|
1 | Q9ES70 (/ISO) |
|
Positive regulation of telomere maintenance via telomerase GO:0032212
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.
|
1 | Q9ES74 (/ISO) |
|
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
|
1 | G5EFM9 (/IGI) |
|
Molting cycle GO:0042303
The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc.
|
1 | G5EFM9 (/IMP) |
|
Protein autophosphorylation GO:0046777
The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
|
1 | Q9ES70 (/ISO) |
|
Positive regulation of telomerase activity GO:0051973
Any process that activates or increases the frequency, rate or extent of telomerase activity, the catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
|
1 | Q9ES74 (/ISO) |
|
Positive regulation of telomere capping GO:1904355
Any process that activates or increases the frequency, rate or extent of telomere capping.
|
1 | Q9ES74 (/ISO) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
15 |
A0A024R8A6 (/IDA)
A0A024R8A6 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
Q8TDX7 (/IDA)
(5 more) |
|
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
|
4 | A0A024R8A6 (/IDA) A0A024R8A6 (/IDA) Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A0A024R8A6 (/IDA) A0A024R8A6 (/IDA) Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
4 | A0A024R8A6 (/IDA) A0A024R8A6 (/IDA) Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q9ES70 (/IDA) Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q9ES70 (/ISO) Q9ES74 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P59895 (/ISS) P59895 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | Q9HC98 (/TAS) Q9HC98 (/TAS) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
2 | Q9HC98 (/IDA) Q9HC98 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q9ES70 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q9ES70 (/ISO) |
|
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
|
1 | Q9ES70 (/ISO) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9ES70 (/ISO) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | G5EFM9 (/IDA) |
|
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
|
1 | Q9ES70 (/ISO) |
|
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | Q9ES70 (/ISO) |
