The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Ypt/Rab-GAP domain of gyp1p, domain 3
".
FunFam 26: Mitotic check point protein (Bub2)
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | P26448 (/IPI) P26448 (/IPI) P26448 (/IPI) P26448 (/IPI) P26448 (/IPI) P36618 (/IPI) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitotic spindle orientation checkpoint GO:0031578
A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.
|
5 | P26448 (/IMP) P26448 (/IMP) P26448 (/IMP) P26448 (/IMP) P26448 (/IMP) |
|
Negative regulation of protein localization to mitotic spindle pole body GO:1902543
Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to mitotic spindle pole body.
|
5 | P26448 (/IMP) P26448 (/IMP) P26448 (/IMP) P26448 (/IMP) P26448 (/IMP) |
|
Mitotic spindle assembly checkpoint GO:0007094
A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.
|
1 | A0A1D8PGP6 (/IMP) |
|
Negative regulation of division septum assembly GO:0010974
Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.
|
1 | P36618 (/IMP) |
|
Negative regulation of septation initiation signaling GO:0031030
Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling.
|
1 | P36618 (/IGI) |
|
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | A0A1D8PGP6 (/IMP) |
|
Positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045737
Any process that activates or increases the frequency, rate or extent of CDK activity.
|
1 | P36618 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Bfa1-Bub2 complex GO:1990334
A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation.
|
6 | P26448 (/IPI) P26448 (/IPI) P26448 (/IPI) P26448 (/IPI) P26448 (/IPI) P36618 (/IPI) |
|
Spindle pole body GO:0005816
The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome.
|
5 | P26448 (/IDA) P26448 (/IDA) P26448 (/IDA) P26448 (/IDA) P26448 (/IDA) |
|
Bfa1-Bub2 complex GO:1990334
A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation.
|
5 | P26448 (/IDA) P26448 (/IDA) P26448 (/IDA) P26448 (/IDA) P26448 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P36618 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P36618 (/HDA) |
|
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
|
1 | P36618 (/HDA) |
|
Mitotic spindle pole body GO:0044732
The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
|
1 | P36618 (/IDA) |
