The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cyclin-like
".
FunFam 4: Cyclin T2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
7SK snRNA binding GO:0097322
Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA).
|
7 | Q6T8E9 (/ISS) Q6T8E9 (/ISS) Q7TQK0 (/ISS) Q8HXN7 (/ISS) Q8HXN7 (/ISS) Q9QWV9 (/ISS) Q9XT26 (/ISS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | O60563 (/IPI) O60583 (/IPI) O96433 (/IPI) O96433 (/IPI) Q7TQK0 (/IPI) Q9QWV9 (/IPI) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
2 | Q7TQK0 (/IDA) Q9QWV9 (/IDA) |
|
Cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538
Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins.
|
2 | O96433 (/ISS) O96433 (/ISS) |
|
RNA polymerase binding GO:0070063
Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
|
2 | O60563 (/IPI) O60583 (/IPI) |
|
RNA polymerase binding GO:0070063
Interacting selectively and non-covalently with an RNA polymerase molecule or complex.
|
2 | Q7TQK0 (/ISO) Q9QWV9 (/ISO) |
|
7SK snRNA binding GO:0097322
Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA).
|
2 | O60563 (/IDA) O60583 (/IDA) |
|
7SK snRNA binding GO:0097322
Interacting selectively and non-covalently with a 7SK small nuclear RNA (7SK snRNA).
|
2 | Q7TQK0 (/ISO) Q9QWV9 (/ISO) |
|
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
|
1 | O60583 (/IPI) |
|
Transcription coactivator binding GO:0001223
Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery.
|
1 | Q7TQK0 (/ISO) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | O60563 (/IDA) |
|
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
|
1 | Q9QWV9 (/ISO) |
|
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
|
1 | O60583 (/ISS) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | O60563 (/IPI) |
|
Transcription factor binding GO:0008134
Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription.
|
1 | Q9QWV9 (/ISO) |
|
SnRNA binding GO:0017069
Interacting selectively and non-covalently with a small nuclear RNA (snRNA).
|
1 | Q9QWV9 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q9QWV9 (/IDA) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q7TQK0 (/ISO) |
|
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
1 | Q9QWV9 (/IDA) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079
Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity.
|
2 | O60563 (/TAS) O60583 (/TAS) |
|
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
|
2 | O96433 (/IDA) O96433 (/IDA) |
|
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
|
2 | O60563 (/TAS) O60583 (/TAS) |
|
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
|
2 | O60563 (/TAS) O60583 (/TAS) |
|
Ventral cord development GO:0007419
The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms.
|
2 | O96433 (/HMP) O96433 (/HMP) |
|
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
|
2 | O96433 (/IDA) O96433 (/IDA) |
|
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
|
2 | O60563 (/TAS) O60583 (/TAS) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | O60563 (/IDA) O60583 (/IDA) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | Q7TQK0 (/ISO) Q9QWV9 (/ISO) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
2 | O60563 (/TAS) O60583 (/TAS) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | O60563 (/IPI) |
|
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | Q9QWV9 (/ISO) |
|
Skeletal muscle tissue development GO:0007519
The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.
|
1 | Q7TQK0 (/IDA) |
|
Early viral transcription GO:0019085
The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell.
|
1 | O60583 (/IDA) |
|
Early viral transcription GO:0019085
The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell.
|
1 | Q7TQK0 (/ISO) |
|
Late viral transcription GO:0019086
The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins.
|
1 | O60583 (/IDA) |
|
Late viral transcription GO:0019086
The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins.
|
1 | Q7TQK0 (/ISO) |
|
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | D3ZC98 (/IEP) |
|
Positive regulation by host of viral transcription GO:0043923
Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA.
|
1 | O60563 (/NAS) |
|
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
|
1 | O60563 (/TAS) |
|
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
|
1 | Q7TQK0 (/ISO) |
|
Regulation of muscle cell differentiation GO:0051147
Any process that modulates the frequency, rate or extent of muscle cell differentiation.
|
1 | Q7TQK0 (/ISS) |
|
Negative regulation of mRNA polyadenylation GO:1900364
Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.
|
1 | O60563 (/IMP) |
|
Negative regulation of mRNA polyadenylation GO:1900364
Any process that stops, prevents or reduces the frequency, rate or extent of mRNA polyadenylation.
|
1 | Q9QWV9 (/ISO) |
There are 20 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cyclin/CDK positive transcription elongation factor complex GO:0008024
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
7 | Q6T8E9 (/ISS) Q6T8E9 (/ISS) Q7TQK0 (/ISS) Q8HXN7 (/ISS) Q8HXN7 (/ISS) Q9QWV9 (/ISS) Q9XT26 (/ISS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
5 | O60563 (/IDA) O60583 (/IDA) O96433 (/IDA) O96433 (/IDA) Q9QWV9 (/IDA) |
|
Cyclin/CDK positive transcription elongation factor complex GO:0008024
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
3 | O96433 (/TAS) O96433 (/TAS) Q9QWV9 (/TAS) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q7TQK0 (/ISO) Q9QWV9 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O60563 (/IDA) O60583 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q7TQK0 (/ISO) Q9QWV9 (/ISO) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | O60563 (/TAS) O60583 (/TAS) |
|
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
|
2 | O96433 (/IDA) O96433 (/IDA) |
|
Polytene chromosome puff GO:0005703
A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription.
|
2 | O96433 (/IDA) O96433 (/IDA) |
|
Transcription elongation factor complex GO:0008023
Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation.
|
2 | O96433 (/IDA) O96433 (/IDA) |
|
Cyclin/CDK positive transcription elongation factor complex GO:0008024
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
2 | O60563 (/IDA) O60583 (/IDA) |
|
Cyclin/CDK positive transcription elongation factor complex GO:0008024
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
2 | O96433 (/IPI) O96433 (/IPI) |
|
Cyclin/CDK positive transcription elongation factor complex GO:0008024
A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit.
|
2 | Q7TQK0 (/ISO) Q9QWV9 (/ISO) |
|
ELL-EAF complex GO:0032783
A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae.
|
2 | O96433 (/IPI) O96433 (/IPI) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q7TQK0 (/ISS) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O60583 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q7TQK0 (/ISO) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O60583 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q7TQK0 (/ISO) |
|
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q7TQK0 (/IDA) |