The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Neutral Protease Domain 2
".
FunFam 12: Thermolysin
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 1 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Metalloendopeptidase activity GO:0004222
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
|
4 | Q81V99 (/ISS) Q81V99 (/ISS) Q81XF5 (/ISS) Q81XF5 (/ISS) |
There are 8 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
10 | P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) Q81V99 (/ISS) Q81V99 (/ISS) Q81XF5 (/ISS) Q81XF5 (/ISS) |
|
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
|
6 | P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
6 | P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) P24153 (/ISS) |
|
Protein secretion by the type II secretion system GO:0015628
The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.
|
6 | P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) |
|
Protein transport by the Sec complex GO:0043952
The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide.
|
6 | P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) |
|
Single-species biofilm formation GO:0044010
A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
|
6 | P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) |
|
Interaction with host via protein secreted by type II secretion system GO:0052051
An interaction with the host organism mediated by a substance secreted by the other organism by a type II secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction.
|
6 | P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) P14756 (/IDA) |
|
Bacterial-type flagellum-dependent swarming motility GO:0071978
Bacterial-type flagellum-dependent cell motility in which the action of numerous flagella results in the smooth movement of a group of cells along a solid surface. Swarming motility is observed in groups of bacteria.
|
6 | P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) P14756 (/IMP) |
There are 0 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
