The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
ProC C-terminal domain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 1: Pyrroline-5-carboxylate reductase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
104 P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA)
(94 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
97 P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA)
(87 more)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
22 A1L2Q8 (/ISS) P54904 (/ISS) P54904 (/ISS) Q4R531 (/ISS) Q58D08 (/ISS) Q58DT4 (/ISS) Q5PQJ6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(12 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) Q53H96 (/IPI) Q53H96 (/IPI) Q96C36 (/IPI) Q96C36 (/IPI) Q9DCC4 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
8 P32263 (/IPI) P32263 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) P32322 (/IPI) Q9DCC4 (/IPI)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
6 P22008 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS)
1-pyrroline-5-carboxylate dehydrogenase activity GO:0003842
Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+).
4 Q5AR01 (/RCA) Q5AR01 (/RCA) Q5B0A5 (/RCA) Q5B0A5 (/RCA)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
4 Q922W5 (/ISO) Q922W5 (/ISO) Q9DCC4 (/ISO) Q9P7Y7 (/ISO)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
3 G5EB79 (/RCA) G5EB79 (/RCA) G5EB79 (/RCA)
Pyrroline-5-carboxylate reductase activity GO:0004735
Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+.
2 P32263 (/IMP) P32263 (/IMP)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
2 Q922W5 (/ISO) Q922W5 (/ISO)
Cytidine deaminase activity GO:0004126
Catalysis of the reaction: cytidine + H2O = uridine + NH3.
1 Q9DCC4 (/ISO)

There are 24 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
L-proline biosynthetic process GO:0055129
The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
97 P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP) P0A9L8 (/IMP)
(87 more)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
23 Q17QJ7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(13 more)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
17 Q17QJ7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(7 more)
Cellular amino acid biosynthetic process GO:0008652
The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.
9 P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) Q53H96 (/TAS) Q53H96 (/TAS) Q96C36 (/TAS) Q96C36 (/TAS)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
7 P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) Q96C36 (/IDA) Q96C36 (/IDA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
7 P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) Q96C36 (/IMP) Q96C36 (/IMP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
6 P22008 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS)
L-proline biosynthetic process GO:0055129
The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
6 A1L2Q8 (/ISS) Q4R531 (/ISS) Q58D08 (/ISS) Q5PQJ6 (/ISS) Q5SPD7 (/ISS) Q9DCC4 (/ISS)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
5 P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
5 P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP) P32322 (/IMP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
4 Q922Q4 (/ISO) Q922Q4 (/ISO) Q922W5 (/ISO) Q922W5 (/ISO)
Glutamine family amino acid metabolic process GO:0009064
The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
4 Q5AR01 (/RCA) Q5AR01 (/RCA) Q5B0A5 (/RCA) Q5B0A5 (/RCA)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
4 Q922Q4 (/ISO) Q922Q4 (/ISO) Q922W5 (/ISO) Q922W5 (/ISO)
Proline metabolic process GO:0006560
The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
3 G5EB79 (/RCA) G5EB79 (/RCA) G5EB79 (/RCA)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 A0A140LG13 (/IMP) F1RDD0 (/IMP) Q503F1 (/IMP)
Proline biosynthetic process GO:0006561
The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
2 P32263 (/IMP) P32263 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 P54904 (/IEP) P54904 (/IEP)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
2 P54904 (/IEP) P54904 (/IEP)
Regulation of mitochondrial membrane potential GO:0051881
Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.
2 Q922W5 (/ISO) Q922W5 (/ISO)
L-proline biosynthetic process GO:0055129
The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
2 Q53H96 (/IDA) Q53H96 (/IDA)
Negative regulation of hydrogen peroxide-induced cell death GO:1903206
Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide-induced cell death.
2 Q922W5 (/ISO) Q922W5 (/ISO)
Cytidine deamination GO:0009972
The removal of amino group in the presence of water.
1 Q9DCC4 (/ISO)
Posttranscriptional regulation of gene expression GO:0010608
Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.
1 Q57XN0 (/IDA)
L-proline biosynthetic process GO:0055129
The chemical reactions and pathways resulting in the formation of L-proline, an L-enantiomer of a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins.
1 Q9DCC4 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
99 P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA) P0A9L8 (/IDA)
(89 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
17 Q17QJ7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q4R6W7 (/ISS) Q58DT4 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS) Q5R9X6 (/ISS)
(7 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 A0A087WZR9 (/IDA) A0A0S2Z5U6 (/IDA) A0A0S2Z5U6 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) P32322 (/IDA) Q96C36 (/IDA) Q96C36 (/IDA)
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
7 P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) P32322 (/TAS) Q96C36 (/TAS) Q96C36 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 A1L2Q8 (/ISS) Q4R531 (/ISS) Q58D08 (/ISS) Q5PQJ6 (/ISS) Q5SPD7 (/ISS) Q9DCC4 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
4 Q922Q4 (/ISO) Q922Q4 (/ISO) Q922W5 (/ISO) Q922W5 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P32263 (/IDA) P32263 (/IDA) Q57XN0 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
2 P54904 (/IDA) P54904 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q922W5 (/HDA) Q922W5 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q53H96 (/TAS) Q53H96 (/TAS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9P7Y7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9DCC4 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...