The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MetI-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Glycine betaine ABC transporter, permease

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Amine transmembrane transporter activity GO:0005275
Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
46 P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA)
(36 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
34 P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI) P14176 (/IPI)
(24 more)
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
21 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(11 more)
Carnitine transmembrane transporter activity GO:0015226
Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
19 Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS)
(9 more)
ATPase-coupled transmembrane transporter activity GO:0042626
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane.
19 Q5LQP6 (/ISS) Q87WH2 (/ISS) Q87WH2 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS)
(9 more)
Amine transmembrane transporter activity GO:0005275
Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group.
18 Q87WH2 (/ISS) Q87WH2 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS)
(8 more)
Sulfur compound transmembrane transporter activity GO:1901682
Enables the transfer of a sulfur compound from one side of a membrane to the other.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
ATPase-coupled quaternary ammonium compound transmembrane transporting activity GO:0015418
Catalysis of the reaction: ATP + H2O + quaternary ammonium(out) = ADP + H(+) + phosphate + quaternary ammonium(in).
10 A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS)
Amino-acid betaine transmembrane transporter activity GO:0015199
Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid.
9 Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA)
Quaternary ammonium group transmembrane transporter activity GO:0015651
Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
3 Q5LKZ6 (/ISS) Q5LQP6 (/ISS) Q5LT64 (/ISS)

There are 18 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Glycine betaine transport GO:0031460
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
58 P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA)
(48 more)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
34 P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA)
(24 more)
Hyperosmotic response GO:0006972
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell.
34 P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP) P14176 (/IEP)
(24 more)
Glycine betaine transport GO:0031460
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
34 P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS) P14176 (/TAS)
(24 more)
Amino-acid betaine transport GO:0015838
The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
19 Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS)
(9 more)
Glycine betaine transport GO:0031460
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
19 Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS)
(9 more)
Cellular hyperosmotic salinity response GO:0071475
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
19 Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS)
(9 more)
Amine transport GO:0015837
The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
18 Q87WH2 (/ISS) Q87WH2 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS)
(8 more)
Quaternary ammonium group transport GO:0015697
The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.
13 A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS) A0A1J9WGQ0 (/ISS)
(3 more)
Amino-acid betaine transport GO:0015838
The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
Choline transport GO:0015871
The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
12 Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP) Q9HTI7 (/IMP)
(2 more)
Glycine betaine catabolic process GO:0031457
The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
Choline catabolic process GO:0042426
The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
Carnitine transmembrane transport GO:1902603
The directed movement of carnitine across a membrane.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
9 Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
9 Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA)
Carnitine transport GO:0015879
The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
9 Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA) Q9RR45 (/IDA)
SOS response GO:0009432
An error-prone process for repairing damaged microbial DNA.
6 Q8Y775 (/EXP) Q8Y775 (/EXP) Q8Y775 (/EXP) Q8Y775 (/EXP) Q8Y775 (/EXP) Q8Y775 (/EXP)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
37 P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA)
(27 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
34 P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA) P14176 (/IDA)
(24 more)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
34 P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM) P14176 (/ISM)
(24 more)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
26 Q87WH2 (/ISS) Q87WH2 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS)
(16 more)
Transmembrane transporter complex GO:1902495
A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.
19 Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC3 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS)
(9 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
18 Q87WH2 (/ISS) Q87WH2 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS) Q87WH4 (/ISS)
(8 more)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
Transmembrane transporter complex GO:1902495
A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.
12 Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA) Q9HTI7 (/IDA)
(2 more)
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing GO:0055052
A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
11 Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS) Q9HXC5 (/ISS)
(1 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P33359 (/RCA) P33359 (/RCA) P33359 (/RCA)
ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing GO:0055052
A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP.
3 P33359 (/RCA) P33359 (/RCA) P33359 (/RCA)
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