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CATH Superfamily 1.10.357.90

Telomerase reverse transcriptase (TERT), thumb domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Telomerase reverse transcriptase (TERT), thumb domain

Telomerase, a ribonucleoprotein complex, replicates the linear ends of eukaryotic chromosomes, thus taking care of the end of replication problem PMID:17997966. The catalytic subunit of telomerase, TERT, consists of four domains, organised into a ring-like structure. This entry represents the all-helical thumb domain of TERT, which is implicated in DNA binding and processivity PMID:20357774.

PMID:17997966 PMID:20357774

GO Diversity

Unique GO annotations
82 Unique GO terms

EC Diversity

Unique EC annotations
1 Unique EC terms

Species Diversity

Unique species annotations
740 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Structures
Domains: 8
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 5
Alignments
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 11
Function
Unique EC: 1
Unique GO: 82
Taxonomy
Unique Species: 740