The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Nuclear pore complex protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
16 A1YK54 (/ISS) A1YK55 (/ISS) A1YK56 (/ISS) A1YK57 (/ISS) A1YK58 (/ISS) A1YK59 (/ISS) A1YK60 (/ISS) A1YK61 (/ISS) A1YK62 (/ISS) A1YK63 (/ISS)
(6 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P57740 (/IPI) Q10331 (/IPI)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
1 P57740 (/IDA)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
1 P57740 (/IMP)
Structural constituent of nuclear pore GO:0017056
The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules.
1 Q8BH74 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
15 A1YK54 (/ISS) A1YK55 (/ISS) A1YK56 (/ISS) A1YK57 (/ISS) A1YK58 (/ISS) A1YK59 (/ISS) A1YK60 (/ISS) A1YK61 (/ISS) A1YK62 (/ISS) A1YK63 (/ISS)
(5 more)
Double-strand break repair via homologous recombination GO:0000724
The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule.
12 A1YK54 (/IMP) A1YK55 (/IMP) A1YK56 (/IMP) A1YK57 (/IMP) A1YK58 (/IMP) A1YK59 (/IMP) A1YK60 (/IMP) A1YK61 (/IMP) A1YK62 (/IMP) A1YK63 (/IMP)
(2 more)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
12 A1YK54 (/IMP) A1YK55 (/IMP) A1YK56 (/IMP) A1YK57 (/IMP) A1YK58 (/IMP) A1YK59 (/IMP) A1YK60 (/IMP) A1YK61 (/IMP) A1YK62 (/IMP) A1YK63 (/IMP)
(2 more)
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
3 A0JMB3 (/IMP) P57740 (/IMP) Q5RGI2 (/IMP)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
2 A0JMB3 (/IMP) Q5RGI2 (/IMP)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
2 P57740 (/IMP) Q9V466 (/IMP)
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
2 P52590 (/ISS) Q8BH74 (/ISS)
Nephron development GO:0072006
The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.
2 P52590 (/ISS) Q8BH74 (/ISS)
Regulation of glycolytic process GO:0006110
Any process that modulates the frequency, rate or extent of glycolysis.
1 P57740 (/TAS)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
1 P57740 (/IDA)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
1 Q8BH74 (/ISO)
MRNA export from nucleus GO:0006406
The directed movement of mRNA from the nucleus to the cytoplasm.
1 P57740 (/TAS)
RRNA export from nucleus GO:0006407
The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins.
1 Q10331 (/ISO)
TRNA export from nucleus GO:0006409
The directed movement of tRNA from the nucleus to the cytoplasm.
1 P57740 (/TAS)
Meiosis I cytokinesis GO:0007110
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells.
1 Q9V466 (/IMP)
Male meiosis cytokinesis GO:0007112
A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
1 Q9V466 (/IMP)
Female gonad development GO:0008585
The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure.
1 Q8BH74 (/ISO)
Viral process GO:0016032
A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle.
1 P57740 (/TAS)
Protein sumoylation GO:0016925
The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.
1 P57740 (/TAS)
Poly(A)+ mRNA export from nucleus GO:0016973
The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm.
1 Q10331 (/IMP)
Viral transcription GO:0019083
The process by which a viral genome, or part of a viral genome, is transcribed within the host cell.
1 P57740 (/TAS)
Eggshell formation GO:0030703
Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration.
1 Q9V466 (/IMP)
Regulation of nucleocytoplasmic transport GO:0046822
Any process that modulates the frequency, rate or extent of the directed movement of substances between the nucleus and the cytoplasm.
1 Q9V466 (/IMP)
Spermatocyte division GO:0048137
The meiotic divisions undergone by the primary and secondary spermatocytes to produce haploid spermatids.
1 Q9V466 (/IMP)
Nuclear pore complex assembly GO:0051292
The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex.
1 Q8BH74 (/ISO)
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression.
1 P57740 (/TAS)
Nephron development GO:0072006
The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.
1 P57740 (/IMP)
Nephron development GO:0072006
The process whose specific outcome is the progression of the nephron over time, from its formation to the mature structure. A nephron is the functional unit of the kidney.
1 Q8BH74 (/ISO)
Intracellular transport of virus GO:0075733
The directed movement of a virus, or part of a virus, within the host cell.
1 P57740 (/TAS)
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
1 P57740 (/TAS)
Positive regulation of protein localization to nucleus GO:1900182
Any process that activates or increases the frequency, rate or extent of protein localization to nucleus.
1 Q9V466 (/IMP)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nuclear pore outer ring GO:0031080
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
14 A1YK54 (/ISS) A1YK55 (/ISS) A1YK56 (/ISS) A1YK57 (/ISS) A1YK58 (/ISS) A1YK59 (/ISS) A1YK60 (/ISS) A1YK61 (/ISS) A1YK62 (/ISS) A1YK63 (/ISS)
(4 more)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
12 A1YK54 (/IDA) A1YK55 (/IDA) A1YK56 (/IDA) A1YK57 (/IDA) A1YK58 (/IDA) A1YK59 (/IDA) A1YK60 (/IDA) A1YK61 (/IDA) A1YK62 (/IDA) A1YK63 (/IDA)
(2 more)
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
4 F1NH49 (/ISS) P52590 (/ISS) Q54N06 (/ISS) Q8BH74 (/ISS)
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
3 P52590 (/IDA) P57740 (/IDA) Q10331 (/IDA)
Nuclear pore outer ring GO:0031080
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
2 P57740 (/IDA) Q10331 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
2 P52590 (/IDA) P57740 (/IDA)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
2 P52590 (/ISS) Q8BH74 (/ISS)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
2 P57740 (/IDA) Q10331 (/IDA)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
2 P52590 (/ISS) Q8BH74 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10331 (/HDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 P57740 (/TAS)
Nuclear pore GO:0005643
Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined.
1 Q8BH74 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q10331 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P57740 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P57740 (/HDA)
Nuclear pore outer ring GO:0031080
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
1 Q8BH74 (/ISO)
Nuclear pore outer ring GO:0031080
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).
1 P57740 (/NAS)
Nuclear membrane GO:0031965
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.
1 Q8BH74 (/ISO)
Nuclear periphery GO:0034399
The portion of the nuclear lumen proximal to the inner nuclear membrane.
1 Q8BH74 (/ISO)
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