The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"High mobility group box domain
".
FunFam 41: HMG box family protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 15 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001227
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
5 | P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) P36631 (/IMP) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P0CY17 (/IDA) P0CY17 (/IDA) P0CY17 (/IDA) P36631 (/IDA) |
|
Proximal promoter sequence-specific DNA binding GO:0000987
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter.
|
4 | P25042 (/IDA) P25042 (/IDA) P25042 (/IDA) P25042 (/IDA) |
|
RNA polymerase II transcription regulator recruiting activity GO:0001135
The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation.
|
4 | P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
4 | P0CY17 (/IDA) P0CY17 (/IDA) P0CY17 (/IDA) P36631 (/IDA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | P0CY17 (/IPI) P0CY17 (/IPI) P0CY17 (/IPI) P36631 (/IPI) |
|
DNA binding, bending GO:0008301
The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
4 | P25042 (/IDA) P25042 (/IDA) P25042 (/IDA) P25042 (/IDA) |
|
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
|
4 | P25042 (/IDA) P25042 (/IDA) P25042 (/IDA) P25042 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding, bending GO:0044377
Interacting selectively and non-covalently with a proximal promoter DNA sequence of a gene transcribed by RNA polymerase II, and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
4 | P0CY17 (/IDA) P0CY17 (/IDA) P0CY17 (/IDA) P36631 (/IDA) |
|
Transcription coactivator activity GO:0003713
A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator.
|
3 | P0CY17 (/IDA) P0CY17 (/IDA) P0CY17 (/IDA) |
|
Sequence-specific DNA binding, bending GO:0044374
The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.
|
3 | P0CY17 (/IDA) P0CY17 (/IDA) P0CY17 (/IDA) |
|
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
2 | P36631 (/IDA) Q5A220 (/IDA) |
|
RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978
Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter.
|
1 | P36631 (/EXP) |
|
DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
1 | P36631 (/IMP) |
|
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
|
1 | Q5A220 (/IGI) |
There are 29 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
5 | P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) Q5A220 (/IMP) |
|
Positive regulation of transcription from RNA polymerase II promoter by pheromones GO:0007329
Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter.
|
4 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) P36631 (/IMP) |
|
Induction of conjugation with cellular fusion GO:0010514
The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types.
|
4 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) P36631 (/IMP) |
|
Positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation GO:0036278
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen.
|
4 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) P36631 (/IMP) |
|
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
4 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) P36631 (/IMP) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
4 | P25042 (/IGI) P25042 (/IGI) P25042 (/IGI) P25042 (/IGI) |
|
Cellular response to osmotic stress GO:0071470
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
|
4 | P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) |
|
Negative regulation of transcription from RNA polymerase II promoter in response to stress GO:0097201
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
4 | P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) P25042 (/IMP) |
|
Positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter GO:1904788
A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion.
|
4 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) P36631 (/IMP) |
|
Positive regulation of mating-type specific transcription from RNA polymerase II promoter GO:0001197
Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter.
|
3 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) |
|
Positive regulation of meiotic cell cycle GO:0051446
Any process that activates or increases the frequency, rate or extent of progression through the meiotic cell cycle.
|
3 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) |
|
Positive regulation of induction of conjugation with cellular fusion GO:1900237
Any process that activates or increases the frequency, rate or extent of induction of conjugation with cellular fusion.
|
3 | P0CY17 (/IMP) P0CY17 (/IMP) P0CY17 (/IMP) |
|
Positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding GO:1905636
Any process that activates or increases the frequency, rate or extent of RNA polymerase II regulatory region sequence-specific DNA binding.
|
3 | P0CY17 (/IDA) P0CY17 (/IDA) P0CY17 (/IDA) |
|
Mating type determination GO:0007531
Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms.
|
2 | G5EHY9 (/IDA) G5EHY9 (/IDA) |
|
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
|
2 | C8VAU1 (/IGI) C8VAU1 (/IGI) |
|
Ascospore formation GO:0030437
The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota).
|
2 | C8VAU1 (/IMP) C8VAU1 (/IMP) |
|
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q5A220 (/IMP) |
|
Mating GO:0007618
The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes.
|
1 | Q4WWK2 (/IMP) |
|
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
|
1 | Q5A220 (/IMP) |
|
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
|
1 | Q5A220 (/IMP) |
|
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | Q5A220 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
|
1 | Q5A220 (/IMP) |
|
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
|
1 | Q5A220 (/IMP) |
|
Sexual sporulation resulting in formation of a cellular spore GO:0043935
The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.
|
1 | Q4WWK2 (/IGI) |
|
Regulation of sexual sporulation resulting in formation of a cellular spore GO:0043940
Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis.
|
1 | Q4WWK2 (/IGI) |
|
Filamentous growth of a population of unicellular organisms GO:0044182
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape.
|
1 | Q5A220 (/IMP) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
1 | Q5A220 (/IMP) |
|
Negative regulation of filamentous growth of a population of unicellular organisms GO:1900429
Any process that stops, prevents or reduces the frequency, rate or extent of filamentous growth of a population of unicellular organisms.
|
1 | Q5A220 (/IMP) |
|
Positive regulation of mitotic G1 cell cycle arrest in response to nitrogen starvation GO:1903694
Any process that activates or increases the frequency, rate or extent of mitotic G1 cell cycle arrest in response to nitrogen starvation.
|
1 | P36631 (/IMP) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear chromatin GO:0000790
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.
|
4 | P25042 (/IC) P25042 (/IC) P25042 (/IC) P25042 (/IC) |
|
RNA polymerase II transcription factor complex GO:0090575
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.
|
4 | P0CY17 (/IPI) P0CY17 (/IPI) P0CY17 (/IPI) P36631 (/IPI) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P36631 (/HDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | P36631 (/IDA) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | P36631 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | P36631 (/HDA) |
|
Tor2-Mei2-Ste11 complex GO:0034064
A protein complex that contains the transcription factor Ste11 and the RNA binding protein Mei2; involved in regulation of conjugation in fission yeast.
|
1 | P36631 (/IDA) |