The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"High mobility group box domain
".
FunFam 35: Maelstrom spermatogenic transposon silencer
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 3 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q96JY0 (/ISM) Q96JY0 (/ISM) |
DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.
|
2 | Q96JY0 (/NAS) Q96JY0 (/NAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8BVN9 (/IPI) |
There are 18 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
1 | Q8BVN9 (/IMP) |
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
|
1 | Q8BVN9 (/IMP) |
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
|
1 | Q8BVN9 (/IMP) |
Synapsis GO:0007129
The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete.
|
1 | Q8BVN9 (/IMP) |
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
|
1 | Q8BVN9 (/IMP) |
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
|
1 | Q8BVN9 (/IMP) |
Intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630
A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered.
|
1 | Q8BVN9 (/IMP) |
Fertilization GO:0009566
The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).
|
1 | Q8BVN9 (/IMP) |
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q8BVN9 (/IMP) |
Gene silencing by RNA GO:0031047
Any process in which RNA molecules inactivate expression of target genes.
|
1 | Q8BVN9 (/IMP) |
PiRNA metabolic process GO:0034587
The chemical reactions and pathways involving piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism.
|
1 | Q8BVN9 (/IMP) |
DNA methylation involved in gamete generation GO:0043046
The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete.
|
1 | Q8BVN9 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q8BVN9 (/IMP) |
Regulation of organ growth GO:0046620
Any process that modulates the frequency, rate or extent of growth of an organ of an organism.
|
1 | Q8BVN9 (/IMP) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
PiP-body GO:0071547
A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.
|
8 | A4UTQ0 (/ISS) Q08D62 (/ISS) Q32KV2 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q4R786 (/ISS) Q96JY0 (/ISS) Q96JY0 (/ISS) |
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
|
1 | Q8BVN9 (/IDA) |
XY body GO:0001741
A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery.
|
1 | Q8BVN9 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q8BVN9 (/IDA) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8BVN9 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8BVN9 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8BVN9 (/TAS) |
Autosome GO:0030849
Any chromosome other than a sex chromosome.
|
1 | Q8BVN9 (/IDA) |
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
|
1 | Q8BVN9 (/IDA) |
P granule GO:0043186
A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes.
|
1 | Q8BVN9 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q8BVN9 (/IDA) |
PiP-body GO:0071547
A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway.
|
1 | Q8BVN9 (/IDA) |