The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Fe,Mn superoxide dismutase (SOD) domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Superoxide dismutase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
165 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(155 more)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
160 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(150 more)
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
160 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(150 more)
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
43 Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS)
(33 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
24 P21276 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI) Q8IAY6 (/IPI)
(14 more)
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
20 Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO) Q8IAY6 (/ISO)
(10 more)
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
6 Q381J5 (/ISM) Q381J5 (/ISM) Q381J5 (/ISM) Q381T3 (/ISM) Q381T3 (/ISM) Q967T0 (/ISM)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
6 Q381J5 (/ISM) Q381J5 (/ISM) Q381J5 (/ISM) Q381T3 (/ISM) Q381T3 (/ISM) Q967T0 (/ISM)
Superoxide dismutase activity GO:0004784
Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide.
1 P21276 (/IMP)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
1 P21276 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P21276 (/IPI)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
165 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(155 more)
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
160 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(150 more)
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
160 P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP)
(150 more)
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
160 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(150 more)
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
160 P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP) P0AGD3 (/IMP)
(150 more)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
160 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(150 more)
Removal of superoxide radicals GO:0019430
Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2).
42 Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS) Q48EJ8 (/ISS)
(32 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
24 B5Z862 (/EXP) B5Z862 (/EXP) P43312 (/EXP) P43312 (/EXP) P43312 (/EXP) P43312 (/EXP) P43312 (/EXP) P43312 (/EXP) P43312 (/EXP) P43312 (/EXP)
(14 more)
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
20 Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS)
(10 more)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
20 Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS) Q8IAY6 (/ISS)
(10 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
11 P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA) P43312 (/IDA)
(1 more)
Cellular response to iron ion GO:0071281
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.
11 P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP) P43312 (/IEP)
(1 more)
Superoxide metabolic process GO:0006801
The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.
6 Q381J5 (/ISM) Q381J5 (/ISM) Q381J5 (/ISM) Q381T3 (/ISM) Q381T3 (/ISM) Q967T0 (/ISM)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P21276 (/IDA)
Circadian rhythm GO:0007623
Any biological process in an organism that recurs with a regularity of approximately 24 hours.
1 P21276 (/IEP)
Response to UV GO:0009411
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
1 Q9LU64 (/IEP)
Response to light intensity GO:0009642
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus.
1 P21276 (/IEP)
Response to ozone GO:0010193
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus.
1 P21276 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
1 P21276 (/IEP)
Response to copper ion GO:0046688
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
1 P21276 (/IEP)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
165 P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA) P0AGD3 (/IDA)
(155 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
160 P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA)
(150 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
160 P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA) P0AGD3 (/HDA)
(150 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
26 Q381J5 (/IDA) Q381J5 (/IDA) Q381J5 (/IDA) Q381T3 (/IDA) Q381T3 (/IDA) Q8IAY6 (/IDA) Q8IAY6 (/IDA) Q8IAY6 (/IDA) Q8IAY6 (/IDA) Q8IAY6 (/IDA)
(16 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 Q381J5 (/IDA) Q381J5 (/IDA) Q381J5 (/IDA) Q381T3 (/IDA) Q381T3 (/IDA) Q967T0 (/IDA)
Glycosome GO:0020015
A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis.
6 Q381J5 (/IDA) Q381J5 (/IDA) Q381J5 (/IDA) Q381T3 (/IDA) Q381T3 (/IDA) Q967T0 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
4 P21276 (/IDA) Q9FMX0 (/IDA) Q9FMX0 (/IDA) Q9LU64 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
4 P21276 (/IDA) Q9FMX0 (/IDA) Q9FMX0 (/IDA) Q9LU64 (/IDA)
Chloroplast nucleoid GO:0042644
The region of a chloroplast to which the DNA is confined.
3 Q9FMX0 (/IDA) Q9FMX0 (/IDA) Q9LU64 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q4Q596 (/ISO) Q4Q597 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P21276 (/IDA) Q57Z58 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q4QIE0 (/ISO) Q57Z58 (/ISO)
Plastid nucleoid GO:0042646
The region of a plastid to which the DNA is confined.
2 Q9FMX0 (/IDA) Q9FMX0 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q57Z58 (/RCA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P21276 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
1 P21276 (/NAS)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
1 P21276 (/IDA)
Chloroplast envelope GO:0009941
The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.
1 P21276 (/IDA)
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