The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Gamma-synuclein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
7 O76070 (/IPI) O76070 (/IPI) Q63544 (/IPI) Q6FHG5 (/IPI) Q6FHG5 (/IPI) Q9Z0F7 (/IPI) Q9Z0F7 (/IPI)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
1 Q63544 (/IDA)
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
1 Q63544 (/IDA)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 Q9Z0F7 (/IGI) Q9Z0F7 (/IGI)
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
2 Q9Z0F7 (/IGI) Q9Z0F7 (/IGI)
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
2 A0A2R8RP85 (/IMP) Q502J6 (/IMP)
Protein secretion GO:0009306
The controlled release of proteins from a cell.
2 Q9Z0F7 (/IDA) Q9Z0F7 (/IDA)
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
2 Q9Z0F7 (/IGI) Q9Z0F7 (/IGI)
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
2 Q9Z0F7 (/IGI) Q9Z0F7 (/IGI)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
2 Q9Z0F7 (/IGI) Q9Z0F7 (/IGI)
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
2 A0A2R8RP85 (/IGI) Q502J6 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Aggressive behavior GO:0002118
A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual.
1 Q63544 (/IEP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q9NZ50 (/TAS)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
1 Q63544 (/NAS)
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
1 Q63544 (/IEP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 Q63544 (/IEP)
Cellular response to hydrostatic pressure GO:0071464
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrostatic pressure stimulus. Hydrostatic pressure is the force acting on an object in a system where the fluid is at rest (as opposed to moving). The weight of the fluid above the object creates pressure on it.
1 Q63544 (/IEP)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q63544 (/IMP)
Response to desipramine GO:1904307
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus.
1 Q63544 (/IEP)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 O76070 (/IDA) O76070 (/IDA) Q9Z0F7 (/IDA) Q9Z0F7 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
3 Q63544 (/IDA) Q9Z0F7 (/IDA) Q9Z0F7 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
2 Q9Z0F7 (/IDA) Q9Z0F7 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 Q9Z0F7 (/ISO) Q9Z0F7 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
2 O76070 (/HDA) O76070 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q63544 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
1 Q63544 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q63544 (/IDA)
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