The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix hairpin bin
".
FunFam 1: Alpha-synuclein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 60 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
|
46 |
O55042 (/ISS)
P37377 (/ISS)
P61138 (/ISS)
P61138 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61140 (/ISS)
(36 more) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
44 |
P37377 (/ISS)
P61138 (/ISS)
P61138 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
(34 more) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
21 |
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
Q16143 (/IDA)
Q16143 (/IDA)
Q16143 (/IDA)
Q16143 (/IDA)
(11 more) |
Cuprous ion binding GO:1903136
Interacting selectively and non-covalently with cuprous ion, copper(1+).
|
21 |
P37840 (/IMP)
P37840 (/IMP)
P37840 (/IMP)
P37840 (/IMP)
P37840 (/IMP)
P37840 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
(11 more) |
Phospholipase inhibitor activity GO:0004859
Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid.
|
15 |
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
(5 more) |
Transition metal ion binding GO:0046914
Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
|
15 |
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
Q16143 (/IMP)
(5 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
8 | O55042 (/IPI) P37377 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
7 | P37377 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
7 | O55042 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
7 | O55042 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
6 | P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
6 | P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Hsp70 protein binding GO:0030544
Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.
|
6 | P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
6 | P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
6 | P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Dynein complex binding GO:0070840
Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
|
6 | P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) P37840 (/IPI) |
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
2 | P37377 (/IDA) Q63754 (/IDA) |
Beta-tubulin binding GO:0048487
Interacting selectively and non-covalently with the microtubule constituent protein beta-tubulin.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Cuprous ion binding GO:1903136
Interacting selectively and non-covalently with cuprous ion, copper(1+).
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
SNARE binding GO:0000149
Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein.
|
1 | O55042 (/ISO) |
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
|
1 | O55042 (/ISO) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | O55042 (/ISO) |
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
|
1 | O55042 (/ISO) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
1 | O55042 (/ISO) |
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | P37377 (/IDA) |
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
|
1 | O55042 (/ISO) |
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
|
1 | O55042 (/ISO) |
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
|
1 | O55042 (/ISO) |
Oxidoreductase activity GO:0016491
Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
|
1 | O55042 (/ISO) |
Kinesin binding GO:0019894
Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
|
1 | O55042 (/ISO) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | P37377 (/IPI) |
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
|
1 | O55042 (/ISO) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | P37377 (/IPI) |
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
|
1 | O55042 (/ISO) |
Hsp70 protein binding GO:0030544
Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size.
|
1 | O55042 (/ISO) |
Histone binding GO:0042393
Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of eukaroytic chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity.
|
1 | O55042 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | O55042 (/ISO) |
Alpha-tubulin binding GO:0043014
Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin.
|
1 | Q63754 (/IDA) |
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027
Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process.
|
1 | O55042 (/ISO) |
Phospholipase binding GO:0043274
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.
|
1 | P37377 (/IPI) |
Phospholipase binding GO:0043274
Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid.
|
1 | O55042 (/ISO) |
Transition metal ion binding GO:0046914
Interacting selectively and non-covalently with a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.
|
1 | Q91ZZ3 (/ISO) |
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | P37377 (/IDA) |
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | O55042 (/ISO) |
Tau protein binding GO:0048156
Interacting selectively and non-covalently with tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS.
|
1 | O55042 (/ISO) |
Arachidonic acid binding GO:0050544
Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer.
|
1 | O55042 (/IDA) |
Phosphoprotein binding GO:0051219
Interacting selectively and non-covalently with a phosphorylated protein.
|
1 | O55042 (/ISO) |
Dynein complex binding GO:0070840
Interacting selectively and non-covalently with a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity.
|
1 | O55042 (/ISO) |
There are 153 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Response to metal ion GO:0010038
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
|
15 |
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
(5 more) |
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
|
7 | O55042 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
SNARE complex assembly GO:0035493
The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
|
7 | O55042 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Response to iron(II) ion GO:0010040
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Regulation of phospholipase activity GO:0010517
Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
|
6 | P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) |
Regulation of transmembrane transporter activity GO:0022898
Any process that modulates the frequency, rate or extent of transmembrane transporter activity.
|
6 | P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) |
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Response to magnesium ion GO:0032026
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of transporter activity GO:0032410
Any process that stops or reduces the activity of a transporter.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of monooxygenase activity GO:0032769
Any process that stops or reduces the activity of a monooxygenase.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
6 | P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) |
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
6 | P37840 (/IC) P37840 (/IC) P37840 (/IC) P37840 (/IC) P37840 (/IC) P37840 (/IC) |
Negative regulation of histone acetylation GO:0035067
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Dopamine biosynthetic process GO:0042416
The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
6 | P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) |
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
6 | P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) |
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
|
6 | P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) |
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
|
6 | P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) |
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
|
6 | P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) P37840 (/ISS) |
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Dopamine uptake involved in synaptic transmission GO:0051583
The directed movement of dopamine into a presynaptic neuron or glial cell. In this context, dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Negative regulation of dopamine uptake involved in synaptic transmission GO:0051585
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of serotonin uptake GO:0051612
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Regulation of norepinephrine uptake GO:0051621
Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.
|
6 | P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) |
Negative regulation of norepinephrine uptake GO:0051622
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Positive regulation of inositol phosphate biosynthetic process GO:0060732
Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of thrombin-activated receptor signaling pathway GO:0070495
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Cellular response to epinephrine stimulus GO:0071872
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an epinephrine stimulus. Epinephrine is a catecholamine that has the formula C9H13NO3; it is secreted by the adrenal medulla to act as a hormone, and released by certain neurons to act as a neurotransmitter active in the central nervous system.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Supramolecular fiber organization GO:0097435
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Negative regulation of mitochondrial electron transport, NADH to ubiquinone GO:1902957
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial electron transport, NADH to ubiquinone.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Positive regulation of glutathione peroxidase activity GO:1903284
Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Positive regulation of hydrogen peroxide catabolic process GO:1903285
Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Regulation of synaptic vesicle recycling GO:1903421
Any process that modulates the frequency, rate or extent of synaptic vesicle recycling.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Regulation of reactive oxygen species biosynthetic process GO:1903426
Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Negative regulation of chaperone-mediated autophagy GO:1904715
Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy.
|
6 | P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) P37840 (/IMP) |
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
|
6 | P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) P37840 (/IGI) |
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
2 | O55042 (/IGI) Q91ZZ3 (/IGI) |
Dopamine metabolic process GO:0042417
The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
|
2 | O55042 (/IGI) Q91ZZ3 (/IGI) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
2 | O55042 (/IGI) Q91ZZ3 (/IGI) |
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
|
2 | O55042 (/IDA) Q91ZZ3 (/IDA) |
Synaptic vesicle endocytosis GO:0048488
A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms.
|
2 | O55042 (/IMP) Q91ZZ3 (/IMP) |
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
|
2 | O55042 (/IGI) Q91ZZ3 (/IGI) |
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
|
1 | O55042 (/IMP) |
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
|
1 | O55042 (/ISO) |
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
1 | P37377 (/IMP) |
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
|
1 | O55042 (/ISO) |
Positive regulation of neurotransmitter secretion GO:0001956
Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.
|
1 | O55042 (/IDA) |
Synaptic transmission, dopaminergic GO:0001963
The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
|
1 | O55042 (/IMP) |
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
|
1 | O55042 (/IMP) |
Neutral lipid metabolic process GO:0006638
The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity.
|
1 | O55042 (/IMP) |
Phospholipid metabolic process GO:0006644
The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester.
|
1 | O55042 (/IMP) |
Activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919
Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
|
1 | O55042 (/ISO) |
Mitochondrial membrane organization GO:0007006
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.
|
1 | O55042 (/IMP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
1 | P37377 (/IEP) |
Adult locomotory behavior GO:0008344
Locomotory behavior in a fully developed and mature organism.
|
1 | O55042 (/IGI) |
Larval locomotory behavior GO:0008345
Locomotory behavior in a larval (immature) organism.
|
1 | Q7SX92 (/IMP) |
Response to iron(II) ion GO:0010040
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.
|
1 | O55042 (/ISO) |
Regulation of phospholipase activity GO:0010517
Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid.
|
1 | O55042 (/ISO) |
Negative regulation of platelet-derived growth factor receptor signaling pathway GO:0010642
Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway.
|
1 | O55042 (/ISO) |
Regulation of glutamate secretion GO:0014048
Any process that modulates the frequency, rate or extent of the controlled release of glutamate.
|
1 | O55042 (/IMP) |
Regulation of dopamine secretion GO:0014059
Any process that modulates the frequency, rate or extent of the regulated release of dopamine.
|
1 | O55042 (/IGI) |
Synaptic vesicle exocytosis GO:0016079
Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft.
|
1 | O55042 (/ISO) |
Synaptic vesicle priming GO:0016082
A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane.
|
1 | O55042 (/ISO) |
Regulation of transmembrane transporter activity GO:0022898
Any process that modulates the frequency, rate or extent of transmembrane transporter activity.
|
1 | O55042 (/ISO) |
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
|
1 | O55042 (/ISO) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
1 | O55042 (/ISO) |
Protein destabilization GO:0031648
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.
|
1 | O55042 (/ISO) |
Response to magnesium ion GO:0032026
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.
|
1 | O55042 (/ISO) |
Negative regulation of transporter activity GO:0032410
Any process that stops or reduces the activity of a transporter.
|
1 | O55042 (/ISO) |
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | O55042 (/ISO) |
Negative regulation of monooxygenase activity GO:0032769
Any process that stops or reduces the activity of a monooxygenase.
|
1 | O55042 (/ISO) |
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
1 | O55042 (/IMP) |
Response to interferon-gamma GO:0034341
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
|
1 | O55042 (/ISO) |
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
|
1 | O55042 (/IMP) |
Negative regulation of histone acetylation GO:0035067
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of an acetyl group to a histone protein.
|
1 | O55042 (/ISO) |
SNARE complex assembly GO:0035493
The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.
|
1 | O55042 (/ISO) |
Regulation of locomotion GO:0040012
Any process that modulates the frequency, rate or extent of locomotion of a cell or organism.
|
1 | O55042 (/IMP) |
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
|
1 | P37377 (/IEP) |
Dopamine biosynthetic process GO:0042416
The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.
|
1 | O55042 (/IMP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
1 | O55042 (/IMP) |
Mitochondrial ATP synthesis coupled electron transport GO:0042775
The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane.
|
1 | O55042 (/IMP) |
Regulation of macrophage activation GO:0043030
Any process that modulates the frequency or rate of macrophage activation.
|
1 | O55042 (/IMP) |
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
|
1 | O55042 (/ISO) |
Negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154
Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process.
|
1 | O55042 (/ISO) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | P37377 (/IMP) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | O55042 (/ISO) |
Cellular response to fibroblast growth factor stimulus GO:0044344
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus.
|
1 | P37377 (/IEP) |
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
|
1 | O55042 (/ISO) |
Negative regulation of exocytosis GO:0045920
Any process that stops, prevents, or reduces the frequency, rate or extent of exocytosis.
|
1 | O55042 (/ISO) |
Positive regulation of exocytosis GO:0045921
Any process that activates or increases the frequency, rate or extent of exocytosis.
|
1 | O55042 (/ISO) |
Negative regulation of dopamine metabolic process GO:0045963
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
|
1 | P37377 (/IMP) |
Negative regulation of dopamine metabolic process GO:0045963
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving dopamine.
|
1 | O55042 (/ISO) |
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
|
1 | O55042 (/IGI) |
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
|
1 | O55042 (/IMP) |
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
|
1 | P37377 (/IMP) |
Behavioral response to cocaine GO:0048148
Any process that results in a change in the behavior of an organism as a result of a cocaine stimulus.
|
1 | O55042 (/ISO) |
Regulation of neuronal synaptic plasticity GO:0048168
A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.
|
1 | O55042 (/IMP) |
Regulation of long-term neuronal synaptic plasticity GO:0048169
A process that modulates long-term neuronal synaptic plasticity, the ability of neuronal synapses to change long-term as circumstances require. Long-term neuronal synaptic plasticity generally involves increase or decrease in actual synapse numbers.
|
1 | O55042 (/IMP) |
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
|
1 | O55042 (/IMP) |
Positive regulation of inflammatory response GO:0050729
Any process that activates or increases the frequency, rate or extent of the inflammatory response.
|
1 | O55042 (/ISO) |
Positive regulation of synaptic transmission GO:0050806
Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
|
1 | O55042 (/IMP) |
Regulation of acyl-CoA biosynthetic process GO:0050812
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.
|
1 | O55042 (/IDA) |
Regulation of acyl-CoA biosynthetic process GO:0050812
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA.
|
1 | O55042 (/IMP) |
Protein complex oligomerization GO:0051259
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
|
1 | O55042 (/IDA) |
Protein tetramerization GO:0051262
The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits.
|
1 | O55042 (/ISO) |
Positive regulation of release of sequestered calcium ion into cytosol GO:0051281
Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria.
|
1 | O55042 (/ISO) |
Negative regulation of dopamine uptake involved in synaptic transmission GO:0051585
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of dopamine into a presynaptic neuron or glial cell.
|
1 | O55042 (/ISO) |
Negative regulation of serotonin uptake GO:0051612
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of serotonin into a cell.
|
1 | O55042 (/ISO) |
Regulation of norepinephrine uptake GO:0051621
Any process that modulates the frequency, rate or extent of the directed movement of the neurotransmitter norepinephrine into a cell.
|
1 | O55042 (/ISO) |
Negative regulation of norepinephrine uptake GO:0051622
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of norepinephrine into a cell.
|
1 | O55042 (/ISO) |
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
|
1 | O55042 (/ISO) |
Excitatory postsynaptic potential GO:0060079
A process that leads to a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
|
1 | O55042 (/IMP) |
Long-term synaptic potentiation GO:0060291
A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.
|
1 | O55042 (/IMP) |
Positive regulation of inositol phosphate biosynthetic process GO:0060732
Any process that increases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.
|
1 | O55042 (/ISO) |
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
|
1 | O55042 (/IMP) |
Negative regulation of thrombin-activated receptor signaling pathway GO:0070495
Any process that stops, prevents, or reduces the frequency, rate or extent of thrombin-activated receptor protein signaling pathway activity. A thrombin receptor signaling pathway is the series of molecular signals generated as a consequence of a thrombin-activated receptor binding to one of its physiological ligands.
|
1 | O55042 (/ISO) |
Response to interleukin-1 GO:0070555
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus.
|
1 | O55042 (/ISO) |
Cellular response to copper ion GO:0071280
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a copper ion stimulus.
|
1 | O55042 (/ISO) |
Dopaminergic neuron differentiation GO:0071542
The process in which a neuroblast acquires the specialized structural and functional features of a dopaminergic neuron, a neuron that secretes dopamine.
|
1 | Q7SX92 (/IGI) |
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | O55042 (/ISO) |
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
|
1 | P37377 (/IGI) |
Regulation of neuron death GO:1901214
Any process that modulates the frequency, rate or extent of neuron death.
|
1 | O55042 (/ISO) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
1 | P37377 (/IMP) |
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
|
1 | O55042 (/ISO) |
Positive regulation of neuron death GO:1901216
Any process that activates or increases the frequency, rate or extent of neuron death.
|
1 | O55042 (/ISO) |
Positive regulation of glutathione peroxidase activity GO:1903284
Any process that activates or increases the frequency, rate or extent of glutathione peroxidase activity.
|
1 | O55042 (/ISO) |
Positive regulation of hydrogen peroxide catabolic process GO:1903285
Any process that activates or increases the frequency, rate or extent of hydrogen peroxide catabolic process.
|
1 | O55042 (/ISO) |
Response to desipramine GO:1904307
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desipramine stimulus.
|
1 | P37377 (/IEP) |
Negative regulation of chaperone-mediated autophagy GO:1904715
Any process that stops, prevents or reduces the frequency, rate or extent of chaperone-mediated autophagy.
|
1 | O55042 (/ISO) |
Regulation of presynapse assembly GO:1905606
Any process that modulates the frequency, rate or extent of presynapse assembly.
|
1 | O55042 (/ISO) |
Regulation of reactive oxygen species metabolic process GO:2000377
Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process.
|
1 | O55042 (/IMP) |
There are 76 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
45 |
O55042 (/ISS)
P37377 (/ISS)
P61138 (/ISS)
P61138 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61140 (/ISS)
(35 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
43 |
P61138 (/ISS)
P61138 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
(33 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
43 |
P61138 (/ISS)
P61138 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
(33 more) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
43 |
P61138 (/ISS)
P61138 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61139 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
P61140 (/ISS)
(33 more) |
Inclusion body GO:0016234
A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
|
22 |
O55042 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
Q16143 (/IDA)
Q16143 (/IDA)
Q16143 (/IDA)
(12 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
21 |
P37840 (/TAS)
P37840 (/TAS)
P37840 (/TAS)
P37840 (/TAS)
P37840 (/TAS)
P37840 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
Q16143 (/TAS)
(11 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
11 |
B5G014 (/IDA)
B5G015 (/IDA)
O55042 (/IDA)
P37377 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
P37840 (/IDA)
(1 more) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
8 | O55042 (/IDA) P37377 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
8 | O55042 (/IDA) P37377 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | O55042 (/IDA) P37377 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
8 | P37377 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) Q63754 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
6 | P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) P37840 (/TAS) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Supramolecular fiber GO:0099512
A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
|
6 | P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) P37840 (/IDA) |
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
|
5 | B5G014 (/IDA) B5G015 (/IDA) O55042 (/IDA) Q4JHT6 (/IDA) Q91ZZ3 (/IDA) |
Inclusion body GO:0016234
A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | P37377 (/IDA) Q63754 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
2 | P37377 (/HDA) Q63754 (/HDA) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
2 | P37377 (/IDA) Q63754 (/IDA) |
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
|
2 | P37377 (/IDA) Q63754 (/IDA) |
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
|
2 | O55042 (/ISO) Q91ZZ3 (/ISO) |
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
1 | O55042 (/ISO) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | O55042 (/ISO) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | O55042 (/ISO) |
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
|
1 | P37377 (/IDA) |
Nuclear outer membrane GO:0005640
The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.
|
1 | O55042 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | O55042 (/ISO) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q91ZZ3 (/HDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | P37377 (/IDA) |
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | O55042 (/ISO) |
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
1 | P37377 (/IDA) |
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
|
1 | O55042 (/ISO) |
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | P37377 (/IDA) |
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | O55042 (/ISO) |
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
|
1 | P37377 (/IDA) |
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
|
1 | O55042 (/ISO) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | P37377 (/IDA) |
Mitochondrial matrix GO:0005759
The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
|
1 | O55042 (/ISO) |
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
|
1 | P37377 (/IDA) |
Rough endoplasmic reticulum GO:0005791
The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.
|
1 | O55042 (/ISO) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | P37377 (/IDA) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
1 | O55042 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | O55042 (/ISO) |
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
|
1 | P37377 (/IDA) |
Ribosome GO:0005840
An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins.
|
1 | O55042 (/ISO) |
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
|
1 | O55042 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | O55042 (/ISO) |
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
|
1 | O55042 (/ISO) |
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
1 | P37377 (/IDA) |
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
|
1 | O55042 (/ISO) |
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
|
1 | O55042 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | O55042 (/ISO) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | O55042 (/ISO) |
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
|
1 | P37377 (/IDA) |
Cytoplasmic vesicle membrane GO:0030659
The lipid bilayer surrounding a cytoplasmic vesicle.
|
1 | O55042 (/ISO) |
Synaptic vesicle membrane GO:0030672
The lipid bilayer surrounding a synaptic vesicle.
|
1 | O55042 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | O55042 (/IMP) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | P37377 (/IDA) |
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
|
1 | O55042 (/ISO) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | O55042 (/ISO) |
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
1 | P37377 (/IDA) |
Presynapse GO:0098793
The part of a synapse that is part of the presynaptic cell.
|
1 | O55042 (/ISO) |
Supramolecular fiber GO:0099512
A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
|
1 | O55042 (/ISO) |
Presynaptic cytosol GO:0099523
The region of the cytosol consisting of all cytosol that is part of the presynapse.
|
1 | Q63754 (/IDA) |
Presynaptic cytosol GO:0099523
The region of the cytosol consisting of all cytosol that is part of the presynapse.
|
1 | Q91ZZ3 (/ISO) |