The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 19: G protein-activated inward rectifier potassium cha...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
47 E1BNE9 (/IPI) E1BNE9 (/IPI) F1MYR9 (/IPI) P48051 (/IPI) P48051 (/IPI) P48051 (/IPI) P48051 (/IPI) P48051 (/IPI) P48051 (/IPI) P48051 (/IPI)
(37 more)
G-protein activated inward rectifier potassium channel activity GO:0015467
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
38 P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS)
(28 more)
Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
18 P48544 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC)
(8 more)
Inward rectifier potassium channel activity GO:0005242
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself.
17 P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS)
(7 more)
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization GO:0086089
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
17 P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC)
(7 more)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
2 P48543 (/ISO) P48543 (/ISO)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
1 P48550 (/IDA)
G-protein alpha-subunit binding GO:0001965
Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide.
1 P48542 (/ISO)
G-protein activated inward rectifier potassium channel activity GO:0015467
Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force.
1 P48542 (/IDA)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q63511 (/IPI)
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization GO:0086089
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P48544 (/IMP)
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization GO:0086089
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
1 P48545 (/ISO)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
35 P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS)
(25 more)
Ventricular cardiac muscle cell membrane repolarization GO:0099625
The process in which ions are transported across the plasma membrane of a ventricular cardiac muscle cell such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
18 P48544 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC)
(8 more)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
18 P48544 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA)
(8 more)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
17 P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC)
(7 more)
Membrane repolarization during atrial cardiac muscle cell action potential GO:0098914
The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
17 P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC) P48549 (/IC)
(7 more)
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
4 P48550 (/IEP) P63251 (/IEP) P63251 (/IEP) P63251 (/IEP)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
4 P48545 (/ISO) P63250 (/ISO) P63250 (/ISO) P63250 (/ISO)
Cellular response to morphine GO:0071315
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure.
1 P48550 (/IEP)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
1 P48544 (/IMP)
Regulation of heart rate by cardiac conduction GO:0086091
A cardiac conduction process that modulates the frequency or rate of heart contraction.
1 P48545 (/ISO)
Membrane repolarization during atrial cardiac muscle cell action potential GO:0098914
The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
1 P48544 (/IMP)
Membrane repolarization during atrial cardiac muscle cell action potential GO:0098914
The process in which ions are transported across a membrane such that the atrial cardiomyocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.
1 P48545 (/ISO)

There are 24 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
40 P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS)
(30 more)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
35 P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS) P48051 (/TAS)
(25 more)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
18 P48544 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA) P48549 (/IDA)
(8 more)
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
17 P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA)
(7 more)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
17 P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA) P48051 (/HDA)
(7 more)
Parallel fiber to Purkinje cell synapse GO:0098688
An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells.
6 P48542 (/IDA) P48543 (/IDA) P48543 (/IDA) P63250 (/IDA) P63250 (/IDA) P63250 (/IDA)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 P48542 (/IDA) P48543 (/IDA) P48543 (/IDA) P63250 (/IDA) P63250 (/IDA) P63250 (/IDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
4 P48545 (/ISO) P63250 (/ISO) P63250 (/ISO) P63250 (/ISO)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
4 P48548 (/IDA) P63251 (/IDA) P63251 (/IDA) P63251 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
4 P48545 (/ISO) P63250 (/ISO) P63250 (/ISO) P63250 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 P48550 (/IDA) P63251 (/IDA) P63251 (/IDA) P63251 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 P48542 (/ISO) P63250 (/ISO) P63250 (/ISO) P63250 (/ISO)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
4 P48548 (/IDA) P63251 (/IDA) P63251 (/IDA) P63251 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
4 P48545 (/ISO) P63250 (/ISO) P63250 (/ISO) P63250 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P48543 (/ISO) P48543 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P48550 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P48542 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q63511 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P48550 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P48542 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P48550 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P48542 (/ISO)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
1 P48550 (/IDA)
Neuronal cell body membrane GO:0032809
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.
1 P48542 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...