The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Putative potassium voltage-gated channel subfamily...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 23 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
6 O43525 (/IDA) O43526 (/IDA) O88943 (/IDA) O88944 (/IDA) Q9JK45 (/IDA) Q9NR82 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 O43525 (/IPI) O43526 (/IPI) P56696 (/IPI) Q9NR82 (/IPI) Q9Z351 (/IPI)
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
4 F1LSD6 (/IMP) F1LY25 (/IMP) Q9JK97 (/IMP) Q9NR82 (/IMP)
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
3 Q8K3F6 (/ISO) Q9JK45 (/ISO) Q9Z351 (/ISO)
Voltage-gated potassium channel activity GO:0005249
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
3 P58126 (/ISS) Q8K3F6 (/ISS) Q9Z351 (/ISS)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
3 O43525 (/IDA) O43526 (/IDA) O88944 (/IDA)
Voltage-gated ion channel activity GO:0005244
Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.
2 Q8K3F6 (/IGI) Q9Z351 (/IGI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 Q8K3F6 (/IPI) Q9Z351 (/IPI)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 Q8K3F6 (/ISO) Q9Z351 (/ISO)
Calmodulin binding GO:0005516
Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states.
2 O88943 (/ISS) P58126 (/ISS)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q8K3F6 (/IMP)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 Q9JK97 (/ISO)
Potassium channel activity GO:0005267
Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism.
1 P56696 (/TAS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 O88944 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q8K3F6 (/ISO)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
1 O43526 (/IPI)
Ankyrin binding GO:0030506
Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins.
1 Q9Z351 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 O88944 (/IPI)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
1 Q8K3F6 (/ISO)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 O88944 (/IPI)
Ion channel binding GO:0044325
Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient.
1 Q8K3F6 (/ISO)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 O88943 (/IPI)
Protein N-terminus binding GO:0047485
Interacting selectively and non-covalently with a protein N-terminus, the end of any peptide chain at which the 2-amino (or 2-imino) function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
1 Q9Z351 (/ISO)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
5 O43525 (/IDA) O43526 (/IDA) O88943 (/IDA) O88944 (/IDA) Q9NR82 (/IDA)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
3 F1LSD6 (/IMP) F1LY25 (/IMP) Q9JK97 (/IMP)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
3 A7MBT2 (/IMP) E9QCR9 (/IMP) F1RE25 (/IMP)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
3 Q8K3F6 (/ISO) Q9JK45 (/ISO) Q9Z351 (/ISO)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
3 P58126 (/ISS) Q8K3F6 (/ISS) Q9Z351 (/ISS)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 Q9JK45 (/ISO) Q9JK97 (/ISO)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
2 O43525 (/TAS) O43526 (/TAS)
Potassium ion transmembrane transport GO:0071805
A process in which a potassium ion is transported from one side of a membrane to the other.
2 Q8K3F6 (/IMP) Q9NR82 (/IMP)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q9JK45 (/IDA)
Potassium ion transport GO:0006813
The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P56696 (/TAS)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 O43526 (/TAS)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q9JK97 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 P56696 (/TAS)
Oligodendrocyte development GO:0014003
The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system.
1 O88944 (/IEP)
Transmission of nerve impulse GO:0019226
The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission.
1 Q9Z351 (/IMP)
Negative regulation of synaptic transmission, dopaminergic GO:0032227
Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.
1 Q9JK97 (/ISO)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 O88944 (/IMP)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
1 Q8K3F6 (/ISO)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 Q9JK97 (/IMP)
Membrane hyperpolarization GO:0060081
The process in which membrane potential increases with respect to its steady-state potential, usually from negative potential to a more negative potential. For example, during the repolarization phase of an action potential the membrane potential often becomes more negative or hyperpolarized before returning to the steady-state resting potential.
1 Q8K3F6 (/IMP)
Ganglion development GO:0061548
The process whose specific outcome is the progression of a ganglion over time, from its formation to the mature structure.
1 O88944 (/IEP)
Cellular response to ammonium ion GO:0071242
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
1 O88944 (/IMP)
Cellular response to ammonium ion GO:0071242
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.
1 Q8K3F6 (/ISO)

There are 35 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
5 O43525 (/IDA) O43526 (/IDA) O88943 (/IDA) O88944 (/IDA) Q9NR82 (/IDA)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
5 O43525 (/IDA) O43526 (/IDA) O88943 (/IDA) O88944 (/IDA) Q9NR82 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 O43525 (/TAS) O43526 (/TAS) P56696 (/TAS) Q9NR82 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O88943 (/IDA) Q8K3F6 (/IDA) Q9Z351 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 Q8K3F6 (/ISO) Q9JK45 (/ISO) Q9Z351 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 P58126 (/ISS) Q8K3F6 (/ISS) Q9JK45 (/ISS)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
3 Q8K3F6 (/ISO) Q9JK45 (/ISO) Q9Z351 (/ISO)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
3 P58126 (/ISS) Q8K3F6 (/ISS) Q9JK45 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 O88944 (/IDA) Q8K3F6 (/IDA) Q9Z351 (/IDA)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
3 O88944 (/IDA) Q8K3F6 (/IDA) Q9Z351 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9JK97 (/ISO) Q9Z351 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 O43525 (/ISS) O43526 (/ISS)
Voltage-gated potassium channel complex GO:0008076
A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential.
2 Q8K3F6 (/IGI) Q9Z351 (/IGI)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
2 Q8K3F6 (/IDA) Q9Z351 (/IDA)
Node of Ranvier GO:0033268
An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed.
2 O43525 (/ISS) O43526 (/ISS)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
2 Q8K3F6 (/ISO) Q9JK97 (/ISO)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
2 O43525 (/ISS) O43526 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9JK97 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q8K3F6 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q9JK97 (/IC)
Clathrin coat GO:0030118
A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.
1 Q9NR82 (/IDA)
Clathrin coat GO:0030118
A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.
1 Q9JK45 (/ISO)
Clathrin coat GO:0030118
A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes.
1 Q9JK45 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 O88944 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q8K3F6 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 O88943 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 Q9Z351 (/ISO)
Somatodendritic compartment GO:0036477
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
1 O88944 (/IDA)
Somatodendritic compartment GO:0036477
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.
1 Q8K3F6 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 O88944 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O88944 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q8K3F6 (/ISO)
Axon initial segment GO:0043194
Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment.
1 Q8K3F6 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 O88944 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q8K3F6 (/ISO)
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