The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 3: vacuolar protein sorting-associated protein 37B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q9H9H4 (/IPI) Q9H9H4 (/IPI) Q9H9H4 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
3 Q9H9H4 (/IPI) Q9H9H4 (/IPI) Q9H9H4 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
1 Q8R0J7 (/ISO)

There are 10 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endosomal transport GO:0016197
The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Macroautophagy GO:0016236
The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Multivesicular body assembly GO:0036258
The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Viral budding via host ESCRT complex GO:0039702
Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Intracellular transport of virus GO:0075733
The directed movement of a virus, or part of a virus, within the host cell.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Positive regulation of viral release from host cell GO:1902188
Any process that activates or increases the frequency, rate or extent of viral release from host cell.
3 Q9H9H4 (/IMP) Q9H9H4 (/IMP) Q9H9H4 (/IMP)
Positive regulation of viral budding via host ESCRT complex GO:1903774
Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex.
3 Q9H9H4 (/IMP) Q9H9H4 (/IMP) Q9H9H4 (/IMP)
Positive regulation of viral release from host cell GO:1902188
Any process that activates or increases the frequency, rate or extent of viral release from host cell.
1 Q8R0J7 (/ISO)
Positive regulation of viral budding via host ESCRT complex GO:1903774
Any process that activates or increases the frequency, rate or extent of viral budding via host ESCRT complex.
1 Q8R0J7 (/ISO)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ESCRT I complex GO:0000813
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
3 Q9H9H4 (/IDA) Q9H9H4 (/IDA) Q9H9H4 (/IDA)
ESCRT I complex GO:0000813
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 Q9H9H4 (/IDA) Q9H9H4 (/IDA) Q9H9H4 (/IDA)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
3 Q9H9H4 (/IDA) Q9H9H4 (/IDA) Q9H9H4 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q9H9H4 (/IDA) Q9H9H4 (/IDA) Q9H9H4 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
3 Q9H9H4 (/IDA) Q9H9H4 (/IDA) Q9H9H4 (/IDA)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
3 Q9H9H4 (/TAS) Q9H9H4 (/TAS) Q9H9H4 (/TAS)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
3 Q9H9H4 (/IDA) Q9H9H4 (/IDA) Q9H9H4 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
3 Q9H9H4 (/HDA) Q9H9H4 (/HDA) Q9H9H4 (/HDA)
ESCRT I complex GO:0000813
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
1 Q8R0J7 (/ISO)
ESCRT I complex GO:0000813
An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes.
1 Q8R0J7 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q8R0J7 (/ISO)
Endosome GO:0005768
A vacuole to which materials ingested by endocytosis are delivered.
1 Q8R0J7 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q8R0J7 (/ISO)
Endosome membrane GO:0010008
The lipid bilayer surrounding an endosome.
1 Q8R0J7 (/ISO)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q8R0J7 (/ISO)
CATH-Gene3D is a Global Biodata Core Resource Learn more...