The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Helix hairpin bin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Tubulin beta chain

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
129 Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS)
(119 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
74 P02554 (/IPI) P02554 (/IPI) Q13885 (/IPI) Q13885 (/IPI) Q13885 (/IPI) Q13885 (/IPI) Q13885 (/IPI) Q13885 (/IPI) Q13885 (/IPI) Q13885 (/IPI)
(64 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
43 Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA)
(33 more)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
43 Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO)
(33 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
2 Q8MST5 (/ISS) Q9VAX7 (/ISS)
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
1 Q18817 (/ISS)
Structural constituent of cytoskeleton GO:0005200
The action of a molecule that contributes to the structural integrity of a cytoskeletal structure.
1 P10874 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
130 Q18817 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS)
(120 more)
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
129 Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS)
(119 more)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
86 Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP) Q3KRE8 (/IMP)
(76 more)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
44 P10874 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO)
(34 more)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
43 Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO)
(33 more)
Microtubule-based process GO:0007017
Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.
43 Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP)
(33 more)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
43 Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA)
(33 more)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
43 Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP)
(33 more)
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
43 Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP) Q9BVA1 (/IMP)
(33 more)
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
43 Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO)
(33 more)
Embryonic brain development GO:1990403
The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure.
43 Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP)
(33 more)
Negative regulation of microtubule polymerization GO:0031115
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.
10 P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP) P32882 (/IMP)
Meiotic spindle organization GO:0000212
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.
3 P52275 (/IGI) P52275 (/IGI) P52275 (/IGI)
Chemosensory behavior GO:0007635
Behavior that is dependent upon the sensation of chemicals.
1 Q18817 (/IMP)
Oviposition GO:0018991
The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water.
1 Q18817 (/IMP)
Dorsal root ganglion development GO:1990791
The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure.
1 P09206 (/IMP)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
129 Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS) Q3KRE8 (/ISS)
(119 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
72 Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA)
(62 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
72 Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA) Q13885 (/IDA)
(62 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
72 Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO) Q7TMM9 (/ISO)
(62 more)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
43 Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA) Q9BVA1 (/IDA)
(33 more)
Microtubule cytoskeleton GO:0015630
The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.
43 Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO) Q9CWF2 (/ISO)
(33 more)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
43 Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA) Q9CWF2 (/IDA)
(33 more)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
43 Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP) Q9CWF2 (/IMP)
(33 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
29 Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA)
(19 more)
Extracellular vesicle GO:1903561
Any vesicle that is part of the extracellular region.
29 Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA) Q13885 (/HDA)
(19 more)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
18 B5G4G7 (/IDA) B5G4G7 (/IDA) B5G4G7 (/IDA) B5G4G7 (/IDA) B5G4G7 (/IDA) B5G4G7 (/IDA) B5G4G7 (/IDA) F1NYB1 (/IDA) F1NYB1 (/IDA) F1NYB1 (/IDA)
(8 more)
Spindle microtubule GO:0005876
Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
4 O17921 (/IDA) P52275 (/IDA) P52275 (/IDA) P52275 (/IDA)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
3 Q18817 (/ISS) Q8MST5 (/ISS) Q9VAX7 (/ISS)
Tubulin complex GO:0045298
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
3 P52275 (/ISS) P52275 (/ISS) P52275 (/ISS)
Axonemal microtubule GO:0005879
A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
2 P41937 (/IDA) P41937 (/IDA)
Tubulin complex GO:0045298
A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly.
1 P10874 (/ISO)
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