The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Dynein heavy chain 2, axonemal

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP-dependent microtubule motor activity, minus-end-directed GO:0008569
Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP.
9 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q0KI05 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VZ77 (/ISS)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 D3YYQ8 (/IC) F7ABZ6 (/IC) Q8WXX0 (/IC)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 Q386I6 (/ISM) Q38B68 (/ISM) Q38B68 (/ISM)
Microtubule motor activity GO:0003777
Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP).
3 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
3 Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
3 A0A0U1RVI8 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS)
ATPase activity, coupled GO:0042623
Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane.
3 A0A0U1RVI8 (/TAS) Q5LJP0 (/TAS) Q9GPN8 (/TAS)
Dynein light chain binding GO:0045503
Interacting selectively and non-covalently with a light chain of the dynein complex.
3 A8I5C3 (/IPI) A8ISA6 (/IPI) Q4AC22 (/IPI)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
1 Q4AC22 (/IDA)

There are 12 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
9 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q0KI05 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VZ77 (/ISS)
Inner dynein arm assembly GO:0036159
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
5 Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
5 Q39575 (/IMP) Q4AC22 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium movement involved in cell motility GO:0060294
Movement of cilia mediated by motor proteins that contributes to the movement of a cell.
4 Q4AC22 (/IGI) Q9MBF8 (/IGI) Q9MBF8 (/IGI) Q9SMH3 (/IGI)
Microtubule-based movement GO:0007018
A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.
3 Q386I6 (/ISM) Q38B68 (/ISM) Q38B68 (/ISM)
Cilium-dependent cell motility GO:0060285
Cell motility due to the motion of one or more eukaryotic cilia. A eukaryotic cilium is a specialized organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
3 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
2 D3YYQ8 (/IC) F7ABZ6 (/IC)
Cilium movement GO:0003341
The directed, self-propelled movement of a cilium.
1 Q8WXX0 (/IMP)
Sensory perception of sound GO:0007605
The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.
1 Q9VJC6 (/IMP)
Response to auditory stimulus GO:0010996
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.
1 Q9VZ77 (/IMP)
Outer dynein arm assembly GO:0036158
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.
1 Q39575 (/IMP)
Sperm competition GO:0046692
Any process that contributes to the success of sperm fertilization in multiply-mated females.
1 Q9VZ77 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
8 A0A0B4KI48 (/ISS) A0A0U1RVI8 (/ISS) E1JJ04 (/ISS) Q5LJP0 (/ISS) Q9GPN8 (/ISS) Q9VAV5 (/ISS) Q9VJC6 (/ISS) Q9VZ77 (/ISS)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
7 Q386I6 (/IDA) Q38B68 (/IDA) Q38B68 (/IDA) Q57WX6 (/IDA) Q57WX6 (/IDA) Q9MBF8 (/IDA) Q9MBF8 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
6 D3YYQ8 (/ISM) E9Q0T8 (/ISM) F7ABZ6 (/ISM) P0C6F1 (/ISM) P0C6F1 (/ISM) Q8BW94 (/ISM)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
5 Q4AC22 (/IMP) Q8WXX0 (/IMP) Q9MBF8 (/IMP) Q9MBF8 (/IMP) Q9SMH3 (/IMP)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
4 Q386I6 (/IDA) Q57WX6 (/IDA) Q57WX6 (/IDA) Q8WXX0 (/IDA)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
4 Q4AC22 (/IDA) Q9MBF8 (/IDA) Q9MBF8 (/IDA) Q9SMH3 (/IDA)
Axonemal dynein complex GO:0005858
A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
3 Q8TD57 (/NAS) Q8WXX0 (/NAS) Q9P225 (/NAS)
Axoneme GO:0005930
The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.
3 Q4Q1Y1 (/ISO) Q4Q9Z6 (/ISO) Q4QFY9 (/ISO)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
3 Q386I6 (/ISM) Q38B68 (/ISM) Q38B68 (/ISM)
Dynein complex GO:0030286
Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity.
3 A0A0U1RVI8 (/TAS) Q5LJP0 (/TAS) Q9GPN8 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q38B68 (/IDA) Q38B68 (/IDA)
Intraciliary transport particle GO:0030990
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
2 Q38B68 (/IDA) Q38B68 (/IDA)
Motile cilium GO:0031514
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.
2 P0C6F1 (/IDA) P0C6F1 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q4Q1Y1 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8WXX0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 E9Q0T8 (/ISO)
Cilium GO:0005929
A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.
1 E9Q0T8 (/ISO)
Intraciliary transport particle GO:0030990
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.
1 Q4Q1Y1 (/ISO)
Inner dynein arm GO:0036156
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 E9Q0T8 (/ISO)
Outer dynein arm GO:0036157
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.
1 Q0KI05 (/ISS)
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