The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
MazG-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Histidine biosynthesis bifunctional protein HisIE

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Phosphoribosyl-ATP diphosphatase. [EC: 3.6.1.31]
1-(5-phospho-beta-D-ribosyl)-ATP + H(2)O = 1-(5-phospho-beta-D-ribosyl)- AMP + diphosphate.
  • The Neurospora crassa enzyme also catalyzes the reactions of EC 1.1.1.23 and EC 3.5.4.19.
2075 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5
(2065 more...)
Phosphoribosyl-AMP cyclohydrolase. [EC: 3.5.4.19]
1-(5-phospho-beta-D-ribosyl)-AMP + H(2)O = 1-(5-phospho-beta-D-ribosyl)- 5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4- carboxamide.
  • The Neurospora crassa enzyme also catalyzes the reactions of EC 1.1.1.23 and EC 3.6.1.31.
2069 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5 A0A027ZUN5
(2059 more...)
Histidinol dehydrogenase. [EC: 1.1.1.23]
L-histidinol + H(2)O + 2 NAD(+) = L-histidine + 2 NADH.
  • Also oxidizes L-histidinal.
  • The Neurospora enzyme also catalyzes the reactions of EC 3.5.4.19 and EC 3.6.1.31.
10 A0A0B0E712 A0A0B0E712 N1P7Z8 N1P7Z8 O74712 P00815 P00815 P07685 P07685 Q12670