The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
lambda repressor-like DNA-binding domains
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 12: HTH-type transcriptional regulator GntR

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
107 P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA)
(97 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
107 P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI) P0ACN7 (/IPI)
(97 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
12 Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KV68 (/ISS)
(2 more)

There are 5 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
107 P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP) P0ACN7 (/IMP)
(97 more)
Cellular response to DNA damage stimulus GO:0006974
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
74 P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP) P0ACP5 (/IEP)
(64 more)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
74 P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA)
(64 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
74 P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA) P0ACP5 (/IDA)
(64 more)
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
12 Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KNQ4 (/ISS) Q9KV68 (/ISS)
(2 more)

There are 1 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
181 P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA) P0ACN7 (/IDA)
(171 more)
CATH-Gene3D is a Global Biodata Core Resource Learn more...