The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Extracellular matrix protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
6 Q16610 (/RCA) Q16610 (/RCA) Q16610 (/RCA) Q16610 (/RCA) Q61508 (/RCA) Q61508 (/RCA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI) Q61508 (/IPI) Q61508 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
4 Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
4 Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
4 Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
4 Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI) Q16610 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
2 Q61508 (/ISO) Q61508 (/ISO)
Interleukin-2 receptor binding GO:0005134
Interacting selectively and non-covalently with the interleukin-2 receptor.
2 Q61508 (/IPI) Q61508 (/IPI)
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
2 Q61508 (/ISO) Q61508 (/ISO)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 Q61508 (/ISO) Q61508 (/ISO)
Laminin binding GO:0043236
Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells.
2 Q61508 (/ISO) Q61508 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
4 Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
4 Q61508 (/ISS) Q61508 (/ISS) Q62894 (/ISS) Q62894 (/ISS)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
4 Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS)
Negative regulation of peptidase activity GO:0010466
Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
4 Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA)
Negative regulation of peptidase activity GO:0010466
Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
4 Q61508 (/ISS) Q61508 (/ISS) Q62894 (/ISS) Q62894 (/ISS)
Negative regulation of bone mineralization GO:0030502
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
4 Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA)
Negative regulation of bone mineralization GO:0030502
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
4 Q61508 (/ISS) Q61508 (/ISS) Q62894 (/ISS) Q62894 (/ISS)
Positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123
Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling.
4 Q16610 (/HMP) Q16610 (/HMP) Q16610 (/HMP) Q16610 (/HMP)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
4 Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
4 Q61508 (/ISS) Q61508 (/ISS) Q62894 (/ISS) Q62894 (/ISS)
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
2 Q61508 (/ISO) Q61508 (/ISO)
Negative regulation of cytokine-mediated signaling pathway GO:0001960
Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway.
2 Q61508 (/IDA) Q61508 (/IDA)
Chondrocyte development GO:0002063
The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.
2 Q61508 (/IMP) Q61508 (/IMP)
Regulation of type 2 immune response GO:0002828
Any process that modulates the frequency, rate, or extent of a type 2 immune response.
2 Q61508 (/IMP) Q61508 (/IMP)
Endochondral bone growth GO:0003416
The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.
2 Q61508 (/IMP) Q61508 (/IMP)
Regulation of transcription by RNA polymerase II GO:0006357
Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 Q61508 (/IMP) Q61508 (/IMP)
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
2 Q61508 (/IMP) Q61508 (/IMP)
Negative regulation of peptidase activity GO:0010466
Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins.
2 Q61508 (/ISO) Q61508 (/ISO)
Regulation of bone mineralization GO:0030500
Any process that modulates the frequency, rate or extent of bone mineralization.
2 Q61508 (/IMP) Q61508 (/IMP)
Negative regulation of bone mineralization GO:0030502
Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization.
2 Q61508 (/ISO) Q61508 (/ISO)
Positive regulation of angiogenesis GO:0045766
Any process that activates or increases angiogenesis.
2 Q61508 (/ISO) Q61508 (/ISO)
Regulation of T cell migration GO:2000404
Any process that modulates the frequency, rate or extent of T cell migration.
2 Q61508 (/IMP) Q61508 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
6 Q16610 (/HDA) Q16610 (/HDA) Q16610 (/HDA) Q16610 (/HDA) Q61508 (/HDA) Q61508 (/HDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
4 Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
4 Q16610 (/NAS) Q16610 (/NAS) Q16610 (/NAS) Q16610 (/NAS)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
4 Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS)
Platelet dense granule lumen GO:0031089
The volume enclosed by the membrane of the platelet dense granule.
4 Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS) Q16610 (/TAS)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
4 Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA) Q16610 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q16610 (/HDA) Q16610 (/HDA) Q16610 (/HDA) Q16610 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q61508 (/HDA) Q61508 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 Q61508 (/IDA) Q61508 (/IDA)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
2 Q61508 (/ISO) Q61508 (/ISO)