The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 83: guanylyl cyclase-activating protein 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
17 A0A0R4IPJ4 (/ISS) A0A0R4IPX8 (/ISS) P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P43081 (/ISS) P79880 (/ISS) P79880 (/ISS) Q1LWS5 (/ISS) Q5MAC8 (/ISS)
(7 more)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
13 A0A0R4IPJ4 (/IDA) A0A0R4IPX8 (/IDA) P43081 (/IDA) P46065 (/IDA) P46065 (/IDA) Q1LWS5 (/IDA) Q5MAC8 (/IDA) Q6PC02 (/IDA) Q6PFM5 (/IDA) Q6ZM98 (/IDA)
(3 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
12 A0A0R4IPJ4 (/IDA) A0A0R4IPX8 (/IDA) P46065 (/IDA) P46065 (/IDA) Q1LWS5 (/IDA) Q5MAC8 (/IDA) Q6PC02 (/IDA) Q6PFM5 (/IDA) Q6ZM98 (/IDA) Q8UUX9 (/IDA)
(2 more)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
9 O95843 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS)
Guanylate cyclase activator activity GO:0030250
Binds to and increases the activity of guanylate cyclase.
9 A0A0R4IPJ4 (/ISS) A0A0R4IPX8 (/ISS) Q1LWS5 (/ISS) Q5MAC8 (/ISS) Q6PC02 (/ISS) Q6PFM5 (/ISS) Q8UUX9 (/ISS) Q8UUY1 (/ISS) Q90WX4 (/ISS)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
7 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P46065 (/ISS) P46065 (/ISS) P79880 (/ISS) P79880 (/ISS)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
7 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P46065 (/ISS) P46065 (/ISS) P79880 (/ISS) P79880 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
5 P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 G3V6G4 (/IMP) P34057 (/IMP) P34057 (/IMP) Q8VH47 (/IMP)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
4 A0A0R4IPJ4 (/IDA) A0A0R4IPX8 (/IDA) Q5MAC8 (/IDA) Q6PFM5 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 A0A0R4IPJ4 (/IDA) A0A0R4IPX8 (/IDA) Q5MAC8 (/IDA) Q6PFM5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P21457 (/IPI) P46065 (/IPI) P46065 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P34057 (/ISO) P34057 (/ISO)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
2 P46065 (/IDA) P46065 (/IDA)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
1 P43081 (/IGI)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
9 O95843 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
6 O95843 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
6 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P43081 (/ISS) P79880 (/ISS) P79880 (/ISS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
5 G3V6G4 (/IMP) P34057 (/IMP) P34057 (/IMP) P43081 (/IMP) Q8VH47 (/IMP)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
5 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P79880 (/ISS) P79880 (/ISS)
Cone photoresponse recovery GO:0036368
The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.
5 A0A0K2CJD5 (/IMP) I3ITF4 (/IMP) Q1LUD3 (/IMP) Q6P974 (/IMP) Q6PC38 (/IMP)
Regulation of rhodopsin mediated signaling pathway GO:0022400
Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
4 O95843 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 P43080 (/NAS) P43080 (/NAS) P43080 (/NAS)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
3 P34057 (/IMP) P34057 (/IMP) P43081 (/IMP)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
3 D3ZII9 (/IDA) P46065 (/IDA) P46065 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 G3V6G4 (/IDA) Q8VH47 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 P34057 (/ISO) P34057 (/ISO)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 P46065 (/ISS) P46065 (/ISS)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 P46065 (/ISS) P46065 (/ISS)
Regulation of guanylate cyclase activity GO:0031282
Any process that modulates the frequency, rate or extent of guanylate cyclase activity.
2 P46065 (/ISS) P46065 (/ISS)
Cone photoresponse recovery GO:0036368
The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.
2 Q4V8S2 (/IGI) Q6PC38 (/IGI)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P34057 (/IMP) P34057 (/IMP)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 P46065 (/IDA) P46065 (/IDA)
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
1 D3ZII9 (/IDA)
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
1 P43081 (/ISO)
Regulation of guanylate cyclase activity GO:0031282
Any process that modulates the frequency, rate or extent of guanylate cyclase activity.
1 P43081 (/IGI)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
1 P43081 (/ISO)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
4 O95843 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
2 D3ZII9 (/IDA) P43081 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 G3V6G4 (/IDA) Q8VH47 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P34057 (/ISO) P34057 (/ISO)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
1 P43081 (/ISO)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
1 D3ZII9 (/IDA)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
1 P43081 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P21457 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 D3ZII9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P43081 (/ISO)
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