The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 78: Hippocalcin-like 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
54 P21457 (/IPI) P37235 (/IPI) P37235 (/IPI) P42324 (/IPI) P42324 (/IPI) P42324 (/IPI) P42324 (/IPI) P42324 (/IPI) P42324 (/IPI) P42324 (/IPI)
(44 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
7 P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P37235 (/TAS) P37235 (/TAS)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
5 P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
4 G3V6G4 (/IMP) P34057 (/IMP) P34057 (/IMP) Q8VH47 (/IMP)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P34057 (/ISO) P34057 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q6PC38 (/ISS)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
14 Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP)
(4 more)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.
14 Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS)
(4 more)
Neuromuscular junction development GO:0007528
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.
14 Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP) Q9VWX8 (/IMP)
(4 more)
Vesicle-mediated transport GO:0016192
A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane.
14 Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS)
(4 more)
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
14 Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI) Q9VWX8 (/IGI)
(4 more)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
5 P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
5 P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS) P35243 (/TAS)
Cone photoresponse recovery GO:0036368
The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.
5 A0A0K2CJD5 (/IMP) I3ITF4 (/IMP) Q1LUD3 (/IMP) Q6P974 (/IMP) Q6PC38 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
4 G3V6G4 (/IMP) P34057 (/IMP) P34057 (/IMP) Q8VH47 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 G3V6G4 (/IDA) Q8VH47 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 P34057 (/ISO) P34057 (/ISO)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 P34057 (/IMP) P34057 (/IMP)
Cone photoresponse recovery GO:0036368
The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.
2 Q4V8S2 (/IGI) Q6PC38 (/IGI)
Regulation of calcium ion transport GO:0051924
Any process that modulates the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
2 P34057 (/IMP) P34057 (/IMP)
Semicircular canal morphogenesis GO:0048752
The process in which the anatomical structures of the semicircular canals are generated and organized.
1 F1R8V7 (/IMP)
Semicircular canal development GO:0060872
The progression of the semicircular canal from its initial formation to the mature structure.
1 F1R8V7 (/IGI)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synaptic vesicle GO:0008021
A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.
14 Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS) Q9VWX8 (/NAS)
(4 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 G3V6G4 (/IDA) Q8VH47 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
2 P34057 (/ISO) P34057 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P21457 (/TAS)
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