The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 60: Parvalbumin, thymic

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
14 A0A060WYV9 (/IDA) A0A060WYV9 (/IDA) A0A060X840 (/IDA) E0WDA2 (/IDA) E0WDA2 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA4 (/IDA) P02625 (/IDA)
(4 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
13 P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS) P0CE71 (/NAS)
(3 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 D3GME4 (/ISS) Q3C2C4 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P02625 (/IDA) P02631 (/IDA)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
2 P02625 (/IDA) P02631 (/IDA)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cochlea development GO:0090102
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.
2 P02625 (/IEP) P02631 (/IEP)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P02631 (/IDA)
Response to wounding GO:0009611
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.
1 P51879 (/ISO)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
1 P02631 (/IDA)
Positive regulation of axon extension involved in regeneration GO:0048691
Any process that activates, maintains or increases the rate of axon extension involved in regeneration.
1 P51879 (/ISO)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P02631 (/IDA)
Protein homotetramerization GO:0051289
The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
1 P51879 (/ISO)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
1 P02631 (/IDA)
Protein homotrimerization GO:0070207
The formation of a protein homotrimer, a macromolecular structure consisting of three noncovalently associated identical subunits.
1 P51879 (/ISO)
Positive regulation of retinal ganglion cell axon guidance GO:1902336
Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance.
1 P02631 (/IDA)
Positive regulation of retinal ganglion cell axon guidance GO:1902336
Any process that activates or increases the frequency, rate or extent of retinal ganglion cell axon guidance.
1 P51879 (/ISO)
Positive regulation of optical nerve axon regeneration GO:1905593
Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration.
1 P02631 (/IDA)
Positive regulation of optical nerve axon regeneration GO:1905593
Any process that activates or increases the frequency, rate or extent of optical nerve axon regeneration.
1 P51879 (/ISO)

There are 29 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
15 A0A060WYV9 (/IDA) A0A060WYV9 (/IDA) A0A060X840 (/IDA) B5DH16 (/IDA) B5DH16 (/IDA) E0WD99 (/IDA) E0WD99 (/IDA) E0WD99 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA)
(5 more)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
13 B5DH16 (/ISS) B5DH16 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) P02619 (/ISS) Q8AYB4 (/ISS)
(3 more)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
13 B5DH16 (/ISS) B5DH16 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) P02619 (/ISS) Q8AYB4 (/ISS)
(3 more)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
13 B5DH16 (/ISS) B5DH16 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) P02619 (/ISS) Q8AYB4 (/ISS)
(3 more)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
13 B5DH16 (/ISS) B5DH16 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) D3GME6 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) E0WD99 (/ISS) P02619 (/ISS) Q8AYB4 (/ISS)
(3 more)
Sarcoplasm GO:0016528
The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum.
10 A0A060WYV9 (/IDA) A0A060WYV9 (/IDA) A0A060X840 (/IDA) E0WDA2 (/IDA) E0WDA2 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA4 (/IDA) P86431 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
8 A0A060WYV9 (/IDA) A0A060WYV9 (/IDA) A0A060X840 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) P32848 (/IDA) P32848 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
6 A0A060WYV9 (/IDA) A0A060WYV9 (/IDA) A0A060X840 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA)
Axon terminus GO:0043679
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it.
6 A0A060WYV9 (/IDA) A0A060WYV9 (/IDA) A0A060X840 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA) E0WDA3 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 P02625 (/IDA) P02631 (/IDA) P32848 (/IDA) P32848 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Cuticular plate GO:0032437
A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P32848 (/ISO) P32848 (/ISO) P51879 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P02625 (/IDA) P02631 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 P32848 (/TAS) P32848 (/TAS)
Stereocilium GO:0032420
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.
2 P02625 (/IDA) P02631 (/IDA)
Cuticular plate GO:0032437
A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.
2 P02625 (/IDA) P02631 (/IDA)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
2 P02625 (/IDA) P02631 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P32848 (/ISO) P32848 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P02631 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P51879 (/ISO)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 P02631 (/IDA)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
1 P51879 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P02625 (/IDA)
Terminal bouton GO:0043195
Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it.
1 P02625 (/HDA)
Supramolecular fiber GO:0099512
A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
1 P02631 (/IDA)
Supramolecular fiber GO:0099512
A polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.
1 P51879 (/ISO)