The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 52: Guanylate cyclase activator 1A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
19 A0A0R4IPX8 (/ISS) F1R110 (/ISS) P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P43081 (/ISS) P79880 (/ISS) P79880 (/ISS) Q1LWS5 (/ISS) Q5MAC7 (/ISS)
(9 more)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
17 A0A0R4IPX8 (/IDA) F1R110 (/IDA) P43081 (/IDA) P46065 (/IDA) P46065 (/IDA) Q1LWS5 (/IDA) Q5MAC7 (/IDA) Q5MAC8 (/IDA) Q6PC02 (/IDA) Q6PFM5 (/IDA)
(7 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
15 A0A0R4IPX8 (/IDA) F1R110 (/IDA) P46065 (/IDA) P46065 (/IDA) Q1LWS5 (/IDA) Q5MAC7 (/IDA) Q5MAC8 (/IDA) Q6PC02 (/IDA) Q6PFM5 (/IDA) Q6ZM98 (/IDA)
(5 more)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
15 O95843 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS)
(5 more)
Guanylate cyclase activator activity GO:0030250
Binds to and increases the activity of guanylate cyclase.
12 A0A0R4IPX8 (/ISS) F1R110 (/ISS) Q1LWS5 (/ISS) Q5MAC7 (/ISS) Q5MAC8 (/ISS) Q6PC02 (/ISS) Q6PFM5 (/ISS) Q8UUX9 (/ISS) Q8UUY0 (/ISS) Q8UUY1 (/ISS)
(2 more)
Calcium sensitive guanylate cyclase activator activity GO:0008048
Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration.
7 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P46065 (/ISS) P46065 (/ISS) P79880 (/ISS) P79880 (/ISS)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
7 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P46065 (/ISS) P46065 (/ISS) P79880 (/ISS) P79880 (/ISS)
Ferrous iron binding GO:0008198
Interacting selectively and non-covalently with ferrous iron, Fe(II).
3 A0A0R4IPX8 (/IDA) Q5MAC8 (/IDA) Q6PFM5 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 A0A0R4IPX8 (/IDA) Q5MAC8 (/IDA) Q6PFM5 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P46065 (/IPI) P46065 (/IPI)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
2 P46065 (/IDA) P46065 (/IDA)
Guanylate cyclase regulator activity GO:0030249
Modulates the activity of guanylate cyclase.
2 P43081 (/IGI) Q8VBV8 (/IGI)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of rhodopsin mediated signaling pathway GO:0022400
Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling.
15 O95843 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS)
(5 more)
Receptor guanylyl cyclase signaling pathway GO:0007168
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
11 Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS)
(1 more)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
11 Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS)
(1 more)
Body fluid secretion GO:0007589
The controlled release of a fluid by a cell or tissue in an animal.
11 Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS)
(1 more)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
6 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P43081 (/ISS) P79880 (/ISS) P79880 (/ISS)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
5 P43080 (/ISS) P43080 (/ISS) P43080 (/ISS) P79880 (/ISS) P79880 (/ISS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
4 O95843 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
4 D3ZEU1 (/IDA) D3ZII9 (/IDA) P46065 (/IDA) P46065 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
3 P43080 (/NAS) P43080 (/NAS) P43080 (/NAS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 P43081 (/IMP) Q8VBV8 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
2 P46065 (/ISS) P46065 (/ISS)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 P43081 (/IMP) Q8VBV8 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
2 P46065 (/ISS) P46065 (/ISS)
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
2 D3ZEU1 (/IDA) D3ZII9 (/IDA)
Regulation of guanylate cyclase activity GO:0031282
Any process that modulates the frequency, rate or extent of guanylate cyclase activity.
2 P43081 (/IGI) Q8VBV8 (/IGI)
Regulation of guanylate cyclase activity GO:0031282
Any process that modulates the frequency, rate or extent of guanylate cyclase activity.
2 P46065 (/ISS) P46065 (/ISS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 P46065 (/IDA) P46065 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 O95843 (/TAS)
Positive regulation of cGMP-mediated signaling GO:0010753
Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response.
1 P43081 (/ISO)
Positive regulation of guanylate cyclase activity GO:0031284
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.
1 P43081 (/ISO)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
15 O95843 (/TAS) P43080 (/TAS) P43080 (/TAS) P43080 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS) Q9UMX6 (/TAS)
(5 more)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
5 A0A0G2K1Y3 (/IDA) D3ZEU1 (/IDA) D3ZID7 (/IDA) D3ZII9 (/IDA) P43081 (/IDA)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
4 A0A0G2K1Y3 (/IDA) D3ZEU1 (/IDA) D3ZID7 (/IDA) D3ZII9 (/IDA)
Photoreceptor outer segment GO:0001750
The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.
2 P43081 (/ISO) Q8VBV8 (/ISO)
Photoreceptor inner segment GO:0001917
The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
2 P43081 (/ISO) Q8VBV8 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 D3ZEU1 (/IDA) D3ZII9 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P43081 (/ISO)