The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 34: Calmodulin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
228 F4IJ46 (/IPI) F4K8M2 (/IPI) P0DH95 (/IPI) P0DH95 (/IPI) P0DH95 (/IPI) P0DH95 (/IPI) P0DH95 (/IPI) P0DH95 (/IPI) P0DH95 (/IPI) P0DH97 (/IPI)
(218 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q03509 (/ISS) Q03509 (/ISS) Q03509 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 P04464 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 F4IEU4 (/TAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
1 P04464 (/IPI)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Detection of calcium ion GO:0005513
The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal.
93 F4K8M2 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS) P59220 (/ISS)
(83 more)
Regulation of photomorphogenesis GO:0010099
Any process that modulates the rate or extent of photomorphogenesis.
92 P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP) P59220 (/IMP)
(82 more)
Calcium-mediated signaling GO:0019722
Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions.
19 P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS) P0DH98 (/TAS)
(9 more)
Response to mechanical stimulus GO:0009612
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.
1 F4K8M2 (/IEP)
Pollen germination GO:0009846
The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture.
1 F4IJ46 (/IMP)
Protein catabolic process GO:0030163
The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 F4IJ46 (/TAS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
33 P04464 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA)
(23 more)
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
16 P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA) P0DH98 (/IDA)
(6 more)
Microtubule GO:0005874
Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle.
16 P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA) P0DH97 (/IDA)
(6 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 F4K8M2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 F4IEU4 (/IDA)