The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 28: Putative calcium-binding mitochondrial carrier pro...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
ATP transmembrane transporter activity GO:0005347
Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q9BV35 (/TAS) Q9BV35 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9BV35 (/IPI) Q9BV35 (/IPI)
ATP transmembrane transporter activity GO:0005347
Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.
1 Q6NUK1 (/IMP)
ATP transmembrane transporter activity GO:0005347
Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other.
1 Q8BMD8 (/ISO)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q6NUK1 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8BMD8 (/ISO)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Regulation of cell death GO:0010941
Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
ATP transport GO:0015867
The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
2 Q9BV35 (/IMP) Q9BV35 (/IMP)
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
2 Q9BV35 (/IMP) Q9BV35 (/IMP)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
2 Q9BV35 (/IMP) Q9BV35 (/IMP)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 Q6GQS1 (/IMP) Q6NUK1 (/IMP)
Regulation of cellular hyperosmotic salinity response GO:1900069
Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.
2 Q9BV35 (/IMP) Q9BV35 (/IMP)
Response to dietary excess GO:0002021
The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure.
1 A2ASZ8 (/IMP)
Regulation of oxidative phosphorylation GO:0002082
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.
1 Q6GQS1 (/IMP)
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
1 Q6NUK1 (/IMP)
Mitochondrial transport GO:0006839
Transport of substances into, out of or within a mitochondrion.
1 Q8BMD8 (/ISO)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q6GQS1 (/ISO)
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
1 Q6GQS1 (/ISS)
Regulation of cell death GO:0010941
Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 Q6NUK1 (/IMP)
Regulation of cell death GO:0010941
Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
1 Q8BMD8 (/ISO)
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
1 A2ASZ8 (/IMP)
ATP transport GO:0015867
The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6NUK1 (/IMP)
ATP transport GO:0015867
The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q8BMD8 (/ISO)
Response to food GO:0032094
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.
1 A2ASZ8 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q6NUK1 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 Q8BMD8 (/ISO)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 A2ASZ8 (/IGI)
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
1 Q6GQS1 (/ISO)
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
1 Q6GQS1 (/ISS)
Camera-type eye development GO:0043010
The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field.
1 A2ASZ8 (/IGI)
Regulation of cellular respiration GO:0043457
Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds.
1 Q6GQS1 (/IMP)
Cellular respiration GO:0045333
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration).
1 A2ASZ8 (/IMP)
ATP metabolic process GO:0046034
The chemical reactions and pathways involving ATP, adenosine triphosphate, a universally important coenzyme and enzyme regulator.
1 A2ASZ8 (/IMP)
Regulation of sequestering of calcium ion GO:0051282
Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system.
1 Q6GQS1 (/IMP)
Adenine nucleotide transport GO:0051503
The directed movement of adenine nucleotides, ATP, ADP, and/or AMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 Q6GQS1 (/IMP)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
1 Q6GQS1 (/ISO)
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
1 Q6GQS1 (/ISS)
Adipose tissue development GO:0060612
The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat.
1 A2ASZ8 (/IMP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
1 A2ASZ8 (/IMP)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
1 Q8BMD8 (/ISO)
Urea homeostasis GO:0097274
Any biological process involved in the maintenance of an internal steady state of urea.
1 Q6GQS1 (/IMP)
Regulation of cellular hyperosmotic salinity response GO:1900069
Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.
1 Q6GQS1 (/ISO)
Regulation of cellular hyperosmotic salinity response GO:1900069
Any process that modulates the frequency, rate or extent of cellular hyperosmotic salinity response.
1 Q6GQS1 (/ISS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
8 A2ASZ8 (/IDA) B1AUS6 (/IDA) Q6GQS1 (/IDA) Q6NUK1 (/IDA) Q8BMD8 (/IDA) Q9BV35 (/IDA) Q9BV35 (/IDA) Q9D5G5 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
8 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS) Q8BMD8 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 O18757 (/ISS) Q5XHA0 (/ISS) Q66L49 (/ISS) Q7T0U6 (/ISS) Q7T0U6 (/ISS) Q7ZY36 (/ISS) Q7ZY36 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 A2ASZ8 (/HDA) B1AUS6 (/HDA) Q6GQS1 (/HDA) Q8BMD8 (/HDA) Q9D5G5 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q6GQS1 (/ISO) Q8BMD8 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q9BV35 (/TAS) Q9BV35 (/TAS)
Microtubule organizing center GO:0005815
An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides.
2 B1AUS6 (/IDA) Q9D5G5 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 B1AUS6 (/IDA) Q9D5G5 (/IDA)
Chromatoid body GO:0033391
A ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).
2 B1AUS6 (/IDA) Q9D5G5 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6NUK1 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8BMD8 (/ISO)
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