The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 26: Epidermal growth factor receptor pathway substrate...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
16 A7BFV9 (/IPI) A7BFV9 (/IPI) E9PSY8 (/IPI) E9PSY8 (/IPI) P42566 (/IPI) P42566 (/IPI) P42567 (/IPI) P42567 (/IPI) P42567 (/IPI) P42567 (/IPI)
(6 more)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
4 P42567 (/ISS) P42567 (/ISS) P42567 (/ISS) P42567 (/ISS)
Cargo receptor activity GO:0038024
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 P42567 (/IPI) P42567 (/IPI) P42567 (/IPI) P42567 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
4 P42566 (/HDA) P42566 (/HDA) Q9UBC2 (/HDA) Q9UBC2 (/HDA)
Polyubiquitin modification-dependent protein binding GO:0031593
Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein.
2 P42566 (/IDA) P42566 (/IDA)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
4 E9PSY8 (/IMP) E9PSY8 (/IMP) Q5JC29 (/IMP) Q5JC29 (/IMP)
Positive regulation of receptor recycling GO:0001921
Any process that activates or increases the frequency, rate or extent of receptor recycling.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
4 P42567 (/ISS) P42567 (/ISS) P42567 (/ISS) P42567 (/ISS)
Receptor-mediated endocytosis of virus by host cell GO:0019065
Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
4 E9PSY8 (/IMP) E9PSY8 (/IMP) Q5JC29 (/IMP) Q5JC29 (/IMP)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Negative regulation of epidermal growth factor receptor signaling pathway GO:0042059
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
4 P42566 (/TAS) P42566 (/TAS) Q9UBC2 (/TAS) Q9UBC2 (/TAS)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
4 E9PSY8 (/IMP) E9PSY8 (/IMP) Q5JC29 (/IMP) Q5JC29 (/IMP)
Regulation of cell population proliferation GO:0042127
Any process that modulates the frequency, rate or extent of cell proliferation.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Clathrin coat assembly GO:0048268
The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
4 P42566 (/TAS) P42566 (/TAS) Q9UBC2 (/TAS) Q9UBC2 (/TAS)
Postsynaptic neurotransmitter receptor internalization GO:0098884
A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
4 E9PSY8 (/IDA) E9PSY8 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Postsynaptic neurotransmitter receptor internalization GO:0098884
A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
4 E9PSY8 (/IMP) E9PSY8 (/IMP) Q5JC29 (/IMP) Q5JC29 (/IMP)
Postsynaptic neurotransmitter receptor internalization GO:0098884
A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Golgi to endosome transport GO:0006895
The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes.
2 P42566 (/IMP) P42566 (/IMP)
Vesicle organization GO:0016050
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
2 P42566 (/TAS) P42566 (/TAS)
Synaptic vesicle budding from presynaptic endocytic zone membrane GO:0016185
Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle.
2 E9PSY8 (/IC) E9PSY8 (/IC)
Receptor-mediated endocytosis of virus by host cell GO:0019065
Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell.
2 P42566 (/IMP) P42566 (/IMP)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
2 P42566 (/IC) P42566 (/IC)
Viral entry into host cell GO:0046718
The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
2 P42566 (/IMP) P42566 (/IMP)
Clathrin coat assembly GO:0048268
The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage.
2 P42566 (/IDA) P42566 (/IDA)

There are 28 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
8 B1AUU8 (/IDA) B1AUU8 (/IDA) E9PSY8 (/IDA) E9PSY8 (/IDA) P42566 (/IDA) P42566 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
6 P42566 (/IDA) P42566 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA)
Clathrin coat of coated pit GO:0030132
The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex.
6 P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) Q60902 (/IDA) Q60902 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
4 E9PSY8 (/IDA) E9PSY8 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Early endosome GO:0005769
A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 P42566 (/TAS) P42566 (/TAS) Q9UBC2 (/TAS) Q9UBC2 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
4 P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 E9PSY8 (/IDA) E9PSY8 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
4 P42566 (/HDA) P42566 (/HDA) Q9UBC2 (/HDA) Q9UBC2 (/HDA)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 E9PSY8 (/IDA) E9PSY8 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
AP-2 adaptor complex GO:0030122
A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).
4 P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA)
Clathrin-coated vesicle GO:0030136
A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
4 P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
4 B1AUU8 (/IDA) B1AUU8 (/IDA) P42566 (/IDA) P42566 (/IDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 E9PSY8 (/IDA) E9PSY8 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Ciliary membrane GO:0060170
The portion of the plasma membrane surrounding a cilium.
4 P42567 (/IDA) P42567 (/IDA) P42567 (/IDA) P42567 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 E9PSY8 (/IDA) E9PSY8 (/IDA) Q5JC29 (/IDA) Q5JC29 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 E9PSY8 (/IMP) E9PSY8 (/IMP) Q5JC29 (/IMP) Q5JC29 (/IMP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 P42567 (/ISO) P42567 (/ISO) P42567 (/ISO) P42567 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9UBC2 (/TAS) Q9UBC2 (/TAS)
Clathrin-coated pit GO:0005905
A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
2 P42566 (/TAS) P42566 (/TAS)
Aggresome GO:0016235
An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules.
2 P42566 (/IDA) P42566 (/IDA)