The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 224: CMD1p Calmodulin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Calcium-dependent protein binding GO:0048306
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of calcium.
10 P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI)
Mitogen-activated protein kinase binding GO:0051019
Interacting selectively and non-covalently with a mitogen-activated protein kinase.
10 P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI) P06787 (/IPI)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Karyogamy involved in conjugation with cellular fusion GO:0000742
During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.
10 P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI)
Karyogamy involved in conjugation with cellular fusion GO:0000742
During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Protein import into nucleus GO:0006606
The directed movement of a protein from the cytoplasm to the nucleus.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
10 P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI) P06787 (/IGI)
Phosphatidylinositol biosynthetic process GO:0006661
The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Endocytosis GO:0006897
A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Cytoskeleton organization GO:0007010
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Cell budding GO:0007114
A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Lysosomal microautophagy GO:0016237
The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Vacuole fusion, non-autophagic GO:0042144
The fusion of two vacuole membranes to form a single vacuole.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Vacuole fusion, non-autophagic GO:0042144
The fusion of two vacuole membranes to form a single vacuole.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Spindle pole body organization GO:0051300
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome.
10 P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP) P06787 (/IMP)
Regulation of membrane tubulation GO:1903525
Any process that modulates the frequency, rate or extent of membrane tubulation.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)

There are 7 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Incipient cellular bud site GO:0000131
The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Central plaque of spindle pole body GO:0005823
One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Cellular bud GO:0005933
A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated.
10 P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA)
Cellular bud tip GO:0005934
The end of a cellular bud distal to the site of attachment to the mother cell.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
10 P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA) P06787 (/HDA)
Cellular bud neck GO:0005935
The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
Mating projection tip GO:0043332
The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
10 P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA) P06787 (/IDA)
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