The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"EF-hand
".
FunFam 149: Mitochondrial calcium uptake family member 3
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
3 | Q8CD10 (/IPI) Q8IYU8 (/IPI) Q8IYU8 (/IPI) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
3 | Q8CD10 (/IPI) Q8IYU8 (/IPI) Q8IYU8 (/IPI) |
|
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
|
1 | Q8CD10 (/IMP) |
|
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q8CD10 (/ISO) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
|
3 | Q86XE3 (/TAS) Q8IYU8 (/TAS) Q8IYU8 (/TAS) |
|
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
|
2 | Q8IYU8 (/IDA) Q8IYU8 (/IDA) |
|
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
|
2 | Q8IYU8 (/IMP) Q8IYU8 (/IMP) |
|
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
|
2 | Q8CD10 (/ISS) Q99P63 (/ISS) |
|
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
|
2 | Q8IYU8 (/IMP) Q8IYU8 (/IMP) |
|
Negative regulation of mitochondrial calcium ion concentration GO:0051562
Any process that decreases the concentration of calcium ions in mitochondria.
|
2 | Q8IYU8 (/IDA) Q8IYU8 (/IDA) |
|
Negative regulation of mitochondrial calcium ion concentration GO:0051562
Any process that decreases the concentration of calcium ions in mitochondria.
|
2 | Q8CD10 (/ISS) Q99P63 (/ISS) |
|
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
|
1 | Q8CD10 (/IMP) |
|
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
|
1 | Q8CD10 (/ISO) |
|
Mitochondrial calcium ion transmembrane transport GO:0006851
The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion.
|
1 | Q99P63 (/ISS) |
|
Calcium import into the mitochondrion GO:0036444
A process in which a calcium ion (Ca2+) is transported from the cytosol, into the mitochondrial matrix.
|
1 | Q8CD10 (/ISO) |
|
Mitochondrial calcium ion homeostasis GO:0051560
Any process involved in the maintenance of an internal steady state of calcium ions within the cytoplasm of a cell or between mitochondria and their surroundings.
|
1 | Q8CD10 (/ISO) |
|
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
|
1 | Q8CD10 (/IMP) |
|
Positive regulation of mitochondrial calcium ion concentration GO:0051561
Any process that increases the concentration of calcium ions in mitochondria.
|
1 | Q99P63 (/ISS) |
|
Negative regulation of mitochondrial calcium ion concentration GO:0051562
Any process that decreases the concentration of calcium ions in mitochondria.
|
1 | Q8CD10 (/ISO) |
There are 15 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
3 | Q8IYU8 (/ISS) Q8IYU8 (/ISS) Q99P63 (/ISS) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
3 | Q86XE3 (/TAS) Q8IYU8 (/TAS) Q8IYU8 (/TAS) |
|
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
|
3 | Q8IYU8 (/ISS) Q8IYU8 (/ISS) Q99P63 (/ISS) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
2 | Q8IYU8 (/IDA) Q8IYU8 (/IDA) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
2 | Q8CD10 (/ISS) Q99P63 (/ISS) |
|
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
|
2 | Q8IYU8 (/IDA) Q8IYU8 (/IDA) |
|
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
|
2 | Q8CD10 (/ISS) Q99P63 (/ISS) |
|
Uniplex complex GO:1990246
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
|
2 | Q8IYU8 (/IDA) Q8IYU8 (/IDA) |
|
Uniplex complex GO:1990246
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
|
2 | Q8CD10 (/ISS) Q99P63 (/ISS) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8CD10 (/HDA) |
|
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
|
1 | Q8CD10 (/IMP) |
|
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
|
1 | Q8CD10 (/ISO) |
|
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
|
1 | Q8CD10 (/ISO) |
|
Calcium channel complex GO:0034704
An ion channel complex through which calcium ions pass.
|
1 | Q8CD10 (/IDA) |
|
Uniplex complex GO:1990246
A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE.
|
1 | Q8CD10 (/ISO) |