The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
EF-hand
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Mitochondrial Rho GTPase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
5 A0A0G2K777 (/IPI) A1L1L6 (/IPI) Q8IMX7 (/IPI) Q8IXI1 (/IPI) Q8IXI2 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 F4J0W4 (/IDA) F4J0W4 (/IDA) Q8IMX7 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 F4J0W4 (/IDA) F4J0W4 (/IDA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 Q8IMX7 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q8IMX7 (/ISM)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 O59781 (/ISO)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 Q55G45 (/ISS)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 O59781 (/ISM)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 O59781 (/IC)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 Q8IMX7 (/IDA)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
16 Q298L5 (/ISS) Q298L5 (/ISS) Q2HJF8 (/ISS) Q32LU1 (/ISS) Q5E9M9 (/ISS) Q5ZM73 (/ISS) Q5ZM83 (/ISS) Q623S8 (/ISS) Q6DIS1 (/ISS) Q6NVC5 (/ISS)
(6 more)
Mitochondrion transport along microtubule GO:0047497
The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
16 Q298L5 (/ISS) Q298L5 (/ISS) Q2HJF8 (/ISS) Q32LU1 (/ISS) Q5E9M9 (/ISS) Q5ZM73 (/ISS) Q5ZM83 (/ISS) Q623S8 (/ISS) Q6DIS1 (/ISS) Q6NVC5 (/ISS)
(6 more)
Mitochondrial outer membrane permeabilization GO:0097345
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
16 Q298L5 (/ISS) Q298L5 (/ISS) Q2HJF8 (/ISS) Q32LU1 (/ISS) Q5E9M9 (/ISS) Q5ZM73 (/ISS) Q5ZM83 (/ISS) Q623S8 (/ISS) Q6DIS1 (/ISS) Q6NVC5 (/ISS)
(6 more)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
3 Q8RXF8 (/IMP) Q8RXF8 (/IMP) Q94263 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
2 F4J0W4 (/IMP) F4J0W4 (/IMP)
Embryo development ending in seed dormancy GO:0009793
The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana.
2 Q8RXF8 (/IMP) Q8RXF8 (/IMP)
Pollen tube growth GO:0009860
Growth of pollen via tip extension of the intine wall.
2 Q8RXF8 (/IMP) Q8RXF8 (/IMP)
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
2 Q8IXI1 (/IMP) Q8IXI2 (/IMP)
Cellular homeostasis GO:0019725
Any process involved in the maintenance of an internal steady state at the level of the cell.
2 Q8BG51 (/ISO) Q8JZN7 (/ISO)
Establishment of mitochondrion localization by microtubule attachment GO:0034640
The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization.
2 A0A0G2K777 (/IMP) A1L1L6 (/IMP)
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
2 A0A0G2K777 (/IMP) A1L1L6 (/IMP)
Mitochondrion transport along microtubule GO:0047497
The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
2 Q8IXI1 (/IMP) Q8IXI2 (/IMP)
Mitochondrion transport along microtubule GO:0047497
The directed movement of a mitochondrion along a microtubule, mediated by motor proteins.
2 Q8BG51 (/ISO) Q8JZN7 (/ISO)
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
2 Q8IXI1 (/TAS) Q8IXI2 (/TAS)
Mitochondrial outer membrane permeabilization GO:0097345
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
2 Q8IXI1 (/IMP) Q8IXI2 (/IMP)
Mitochondrial outer membrane permeabilization GO:0097345
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.
2 Q8BG51 (/ISO) Q8JZN7 (/ISO)
Regulation of organelle transport along microtubule GO:1902513
Any process that modulates the frequency, rate or extent of organelle transport along microtubule.
2 A0A0G2K777 (/IMP) A1L1L6 (/IMP)
Microtubule cytoskeleton organization GO:0000226
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.
1 Q8IMX7 (/IMP)
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
1 Q8IXI2 (/TAS)
Axonal transport of mitochondrion GO:0019896
The directed movement of mitochondria along microtubules in nerve cell axons.
1 Q8IMX7 (/IMP)
Establishment of mitochondrion localization by microtubule attachment GO:0034640
The directed movement of a mitochondrion by attachment to a microtubule, followed by elongation of the microtubule by tubulin polymerization.
1 Q8BG51 (/ISO)
Establishment of mitochondrion localization, microtubule-mediated GO:0034643
The directed movement of the mitochondrion to a specific location, by a process involving microtubules.
1 Q8IMX7 (/IMP)
Regulation of neurotransmitter secretion GO:0046928
Any process that modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell.
1 Q8BG51 (/ISO)
Synaptic vesicle transport GO:0048489
The directed movement of synaptic vesicles.
1 Q8IMX7 (/IMP)
Mitochondrion localization GO:0051646
Any process in which a mitochondrion or mitochondria are transported to, and/or maintained in, a specific location within the cell.
1 Q8IMX7 (/IMP)
Regulation of organelle transport along microtubule GO:1902513
Any process that modulates the frequency, rate or extent of organelle transport along microtubule.
1 Q8BG51 (/ISO)
Mitochondrion-endoplasmic reticulum membrane tethering GO:1990456
The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
1 O59781 (/IC)
Mitochondrion-endoplasmic reticulum membrane tethering GO:1990456
The attachment of a mitochondrion and an endoplasmic reticulum via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles.
1 Q55G45 (/TAS)

There are 21 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of mitochondrial outer membrane GO:0031307
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
16 Q298L5 (/ISS) Q298L5 (/ISS) Q2HJF8 (/ISS) Q32LU1 (/ISS) Q5E9M9 (/ISS) Q5ZM73 (/ISS) Q5ZM83 (/ISS) Q623S8 (/ISS) Q6DIS1 (/ISS) Q6NVC5 (/ISS)
(6 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
10 A0A0R4IGX0 (/IDA) A0A0R4IVN5 (/IDA) A0A286Y9M7 (/IDA) B3DI88 (/IDA) F4J0W4 (/IDA) F4J0W4 (/IDA) Q32LU1 (/IDA) Q6NVC5 (/IDA) Q8RXF8 (/IDA) Q8RXF8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 Q8BG51 (/HDA) Q8JZN7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q8IXI1 (/TAS) Q8IXI2 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q8IXI1 (/TAS) Q8IXI2 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q8IXI1 (/HDA) Q8IXI2 (/HDA)
Integral component of mitochondrial outer membrane GO:0031307
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q8IXI1 (/IDA) Q8IXI2 (/IDA)
Integral component of mitochondrial outer membrane GO:0031307
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q8BG51 (/ISO) Q8JZN7 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O59781 (/HDA)
Nuclear envelope GO:0005635
The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space).
1 O59781 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q55G45 (/ISS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q8IXI2 (/NAS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q55G45 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q55G45 (/ISS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 Q8IXI2 (/TAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q8JZN7 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O59781 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8IXI1 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q8JZN7 (/ISO)
ERMES complex GO:0032865
A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.
1 O59781 (/ISO)
ERMES complex GO:0032865
A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.
1 Q55G45 (/TAS)