The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Annexin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: Annexin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 17 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peroxidase activity GO:0004601
Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O.
7 Q69DC2 (/IDA) Q69DC2 (/IDA) Q69DC2 (/IDA) Q69DC2 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
5 D2D2Z9 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
5 D2D2Z9 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
4 Q69DC2 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA) Q69DC2 (/RCA)
Copper ion binding GO:0005507
Interacting selectively and non-covalently with copper (Cu) ions.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 D2D2Z9 (/IDA) O82090 (/IDA) P93157 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
3 Q9SYT0 (/ISS) Q9SYT0 (/ISS) Q9SYT0 (/ISS)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
MRNA binding GO:0003729
Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
2 Q9ZVJ6 (/IDA) Q9ZVJ6 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 P93157 (/RCA) P93158 (/RCA)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 O82090 (/IDA)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 O82090 (/IDA)
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
1 O82090 (/IDA)
ATPase activity GO:0016887
Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction.
1 O82090 (/IDA)
Heme binding GO:0020037
Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.
1 D2D2Z9 (/RCA)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
12 Q94CK4 (/IEP) Q94CK4 (/IEP) Q9LX07 (/IEP) Q9LX08 (/IEP) Q9SE45 (/IEP) Q9SE45 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9XEE2 (/IEP)
(2 more)
Response to cold GO:0009409
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism.
12 Q94CK4 (/IEP) Q94CK4 (/IEP) Q9LX07 (/IEP) Q9LX08 (/IEP) Q9SE45 (/IEP) Q9SE45 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9XEE2 (/IEP)
(2 more)
Response to water deprivation GO:0009414
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water.
12 Q94CK4 (/IEP) Q94CK4 (/IEP) Q9LX07 (/IEP) Q9LX08 (/IEP) Q9SE45 (/IEP) Q9SE45 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9XEE2 (/IEP)
(2 more)
Response to salt stress GO:0009651
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.
12 Q94CK4 (/IEP) Q94CK4 (/IEP) Q9LX07 (/IEP) Q9LX08 (/IEP) Q9SE45 (/IEP) Q9SE45 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9XEE2 (/IEP)
(2 more)
Seed trichome elongation GO:0090378
The process in which a seed trichome irreversibly increases in size in one
6 D2D2Z9 (/IEP) O82090 (/IEP) Q69DC2 (/IEP) Q69DC2 (/IEP) Q69DC2 (/IEP) Q69DC2 (/IEP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
5 Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9ZVJ6 (/IMP) Q9ZVJ6 (/IMP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
5 Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9ZVJ6 (/IMP) Q9ZVJ6 (/IMP)
Primary root development GO:0080022
The process whose specific outcome is the progression of the primary root over time, from its formation to the mature structure. The primary root develops directly from the embryonic radicle.
4 Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9XEE2 (/IMP)
Phloem sucrose unloading GO:0110128
The process of unloading sucrose that is produced in the source tissues, from the sieve tube or companion cell of the phloem into the sink tissues.
4 Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9SYT0 (/IMP) Q9XEE2 (/IMP)
Response to osmotic stress GO:0006970
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
3 Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP)
Response to abscisic acid GO:0009737
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus.
3 Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP)
Response to cadmium ion GO:0046686
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
3 Q9SYT0 (/IEP) Q9SYT0 (/IEP) Q9SYT0 (/IEP)
Calcium ion transmembrane transport GO:0070588
A process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Fruit ripening GO:0009835
An aging process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal.
2 P93157 (/TAS) P93158 (/TAS)
Secretion by cell GO:0032940
The controlled release of a substance by a cell.
2 P93157 (/TAS) P93158 (/TAS)
Response to oxidative stress GO:0006979
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
1 P93157 (/TAS)
Response to red or far red light GO:0009639
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs.
1 Q9LX08 (/IEP)
Polysaccharide transport GO:0015774
The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.
1 Q9XEE2 (/TAS)
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
1 P93157 (/TAS)
Regulation of cellulose biosynthetic process GO:2001006
Any process that modulates the frequency, rate or extent of cellulose biosynthetic process.
1 P93157 (/TAS)

There are 16 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Vacuole GO:0005773
A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.
5 Q9SE45 (/IDA) Q9SE45 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Plasmodesma GO:0009506
A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell.
5 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9ZVJ6 (/IDA) Q9ZVJ6 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
4 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9XEE2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 D2D2Z9 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Thylakoid GO:0009579
A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.
4 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9XEE2 (/IDA)
Apoplast GO:0048046
The cell membranes and intracellular regions in a plant are connected through plasmodesmata, and plants may be described as having two major compartments: the living symplast and the non-living apoplast. The apoplast is external to the plasma membrane and includes cell walls, intercellular spaces and the lumen of dead structures such as xylem vessels. Water and solutes pass freely through it.
4 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9XEE2 (/IDA)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Vacuolar membrane GO:0005774
The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Chloroplast GO:0009507
A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Chloroplast stroma GO:0009570
The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
3 Q9SYT0 (/IDA) Q9SYT0 (/IDA) Q9SYT0 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9XEE2 (/IDA)
Nucleolus GO:0005730
A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
1 D2D2Z9 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 D2D2Z9 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P93157 (/ISM)