The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Frizzled cysteine-rich domain
".
FunFam 7: Frizzled class receptor 10
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 12 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
4 | O00144 (/IPI) O00144 (/IPI) Q8BKG4 (/IPI) Q8BKG4 (/IPI) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | Q8K4C8 (/IDA) Q9R216 (/IDA) Q9ULW2 (/IDA) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | Q90WM3 (/IMP) Q9PTT8 (/IMP) Q9W6E3 (/IMP) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) Q9R216 (/ISO) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | O00144 (/TAS) O00144 (/TAS) Q9ULW2 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q8TAN2 (/IPI) Q9ULW2 (/IPI) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | O00144 (/IPI) O00144 (/IPI) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
2 | O00144 (/ISS) O00144 (/ISS) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
2 | O00144 (/IPI) O00144 (/IPI) |
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
1 | Q9R216 (/ISO) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q9R216 (/ISO) |
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
|
1 | Q9R216 (/ISO) |
There are 56 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
4 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) Q9R216 (/ISS) |
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
3 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) |
Release of cytochrome c from mitochondria GO:0001836
The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
3 | Q90WM3 (/IMP) Q9PTT8 (/IMP) Q9W6E3 (/IMP) |
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
|
3 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Regulation of cytosolic calcium ion concentration GO:0051480
Any process involved in the maintenance of an internal steady state of calcium ions within the cytosol of a cell or between the cytosol and its surroundings.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Negative regulation of mitochondrial depolarization GO:0051902
Any process that stops, prevents, or reduces the frequency, rate or extent of the change in the membrane potential of the mitochondria from negative to positive.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Negative regulation of necroptotic process GO:0060546
Any process that decreases the rate, frequency or extent of a necroptotic process, a necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) |
Epiboly GO:0090504
The expansion of one cell sheet over other cells or yolk.
|
3 | Q90WM3 (/IGI) Q9PTT8 (/IGI) Q9W6E3 (/IGI) |
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901029
Any process that stops, prevents or reduces the frequency, rate or extent of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904393
Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
|
3 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) |
Negative regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904394
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
|
3 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) |
Bone regeneration GO:1990523
The regrowth of bone following its loss or destruction.
|
3 | O00144 (/ISS) O00144 (/ISS) Q8K4C8 (/ISS) |
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
|
2 | O00144 (/TAS) O00144 (/TAS) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
2 | Q8BKG4 (/IGI) Q8BKG4 (/IGI) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Non-canonical Wnt signaling pathway via JNK cascade GO:0038031
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
2 | O00144 (/IMP) O00144 (/IMP) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Negative regulation of cell cycle arrest GO:0071157
Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
2 | O00144 (/IMP) O00144 (/IMP) |
Negative regulation of cell cycle arrest GO:0071157
Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
2 | Q8K4C8 (/ISS) Q9R216 (/ISS) |
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
2 | O00144 (/IMP) O00144 (/IMP) |
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
2 | Q8K4C8 (/ISS) Q9R216 (/ISS) |
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
|
1 | Q9R216 (/IMP) |
Neuroblast proliferation GO:0007405
The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron.
|
1 | Q9R216 (/IMP) |
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
|
1 | Q9R216 (/IMP) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
1 | Q8K4C8 (/IDA) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
1 | Q9R216 (/ISO) |
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
1 | Q9ULW2 (/ISS) |
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
|
1 | Q9R216 (/IMP) |
Positive regulation of bone mineralization GO:0030501
Any process that activates or increases the frequency, rate or extent of bone mineralization.
|
1 | Q9R216 (/IMP) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q9ULW2 (/IMP) |
Negative regulation of GTPase activity GO:0034260
Any process that stops or reduces the rate of GTP hydrolysis by a GTPase.
|
1 | Q9ULW2 (/IMP) |
Non-canonical Wnt signaling pathway via JNK cascade GO:0038031
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade.
|
1 | Q9ULW2 (/IMP) |
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | Q9ULW2 (/IMP) |
Negative regulation of neuron apoptotic process GO:0043524
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons.
|
1 | Q9R216 (/ISO) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
1 | Q9ULW2 (/IMP) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
1 | Q9ULW2 (/IDA) |
Negative regulation of cell cycle arrest GO:0071157
Any process that decreases the rate, frequency, or extent of cell cycle arrest, the process in which the cell cycle is halted during one of the normal phases.
|
1 | Q9R216 (/ISO) |
Cellular response to retinoic acid GO:0071300
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.
|
1 | Q9ULW2 (/ISS) |
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
1 | Q9R216 (/IMP) |
Postsynapse organization GO:0099173
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
|
1 | Q8K4C8 (/IDA) |
Postsynapse organization GO:0099173
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
|
1 | Q8K4C8 (/IMP) |
Postsynapse organization GO:0099173
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse.
|
1 | Q9R216 (/ISO) |
Regulation of postsynaptic cytosolic calcium ion concentration GO:0099566
Any process that regulates the concentration of calcium in the postsynaptic cytosol.
|
1 | Q8K4C8 (/IDA) |
Regulation of postsynaptic cytosolic calcium ion concentration GO:0099566
Any process that regulates the concentration of calcium in the postsynaptic cytosol.
|
1 | Q8K4C8 (/IMP) |
Regulation of postsynaptic cytosolic calcium ion concentration GO:0099566
Any process that regulates the concentration of calcium in the postsynaptic cytosol.
|
1 | Q9R216 (/ISO) |
Regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904393
Any process that modulates the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
|
1 | Q9R216 (/IDA) |
Negative regulation of skeletal muscle acetylcholine-gated channel clustering GO:1904394
Any process that stops, prevents or reduces the frequency, rate or extent of skeletal muscle acetylcholine-gated channel clustering.
|
1 | Q9R216 (/IMP) |
Bone regeneration GO:1990523
The regrowth of bone following its loss or destruction.
|
1 | Q9R216 (/IMP) |
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
|
1 | Q9R216 (/ISO) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O00144 (/IDA) O00144 (/IDA) Q8K4C8 (/IDA) Q9R216 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | O00144 (/IDA) O00144 (/IDA) Q9ULW2 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) Q9R216 (/ISO) |
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Golgi apparatus GO:0005794
A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | O00144 (/IDA) O00144 (/IDA) Q9ULW2 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
3 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) Q9R216 (/ISO) |
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
|
3 | O00144 (/ISS) O00144 (/ISS) Q9R216 (/ISS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | Q8BKG4 (/ISO) Q8BKG4 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | O00144 (/TAS) O00144 (/TAS) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | O00144 (/TAS) O00144 (/TAS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q9ULW2 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9R216 (/ISO) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q9ULW2 (/TAS) |
Filopodium membrane GO:0031527
The portion of the plasma membrane surrounding a filopodium.
|
1 | Q9R216 (/IDA) |
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
|
1 | Q9R216 (/IDA) |
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
1 | Q8K4C8 (/IDA) |
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
|
1 | Q9R216 (/ISO) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | Q8K4C8 (/IDA) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | Q8K4C8 (/IMP) |
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
|
1 | Q9R216 (/ISO) |