The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Frizzled cysteine-rich domain
".
FunFam 6: Frizzled-3 protein
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 9 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q61086 (/IPI) Q9NPG1 (/IPI) Q9NPG1 (/IPI) Q9NPG1 (/IPI) |
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
3 | Q9NPG1 (/IPI) Q9NPG1 (/IPI) Q9NPG1 (/IPI) |
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
3 | Q9NPG1 (/NAS) Q9NPG1 (/NAS) Q9NPG1 (/NAS) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
3 | Q9NPG1 (/IPI) Q9NPG1 (/IPI) Q9NPG1 (/IPI) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | Q9NPG1 (/IC) Q9NPG1 (/IC) Q9NPG1 (/IC) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
3 | Q9NPG1 (/NAS) Q9NPG1 (/NAS) Q9NPG1 (/NAS) |
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
1 | Q61086 (/ISO) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | Q61086 (/ISO) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
1 | Q61086 (/IMP) |
There are 36 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
3 | Q9NPG1 (/ISS) Q9NPG1 (/ISS) Q9NPG1 (/ISS) |
Wnt signaling pathway, calcium modulating pathway GO:0007223
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).
|
3 | Q9NPG1 (/TAS) Q9NPG1 (/TAS) Q9NPG1 (/TAS) |
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
|
3 | Q9NPG1 (/ISS) Q9NPG1 (/ISS) Q9NPG1 (/ISS) |
Negative regulation of mitotic cell cycle, embryonic GO:0045976
Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.
|
3 | Q9NPG1 (/ISS) Q9NPG1 (/ISS) Q9NPG1 (/ISS) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
3 | Q9NPG1 (/IDA) Q9NPG1 (/IDA) Q9NPG1 (/IDA) |
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
3 | Q9NPG1 (/NAS) Q9NPG1 (/NAS) Q9NPG1 (/NAS) |
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
|
3 | Q9NPG1 (/ISS) Q9NPG1 (/ISS) Q9NPG1 (/ISS) |
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
3 | B1WB86 (/IMP) Q5TZ38 (/IMP) Q61086 (/IMP) |
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
|
3 | Q9NPG1 (/ISS) Q9NPG1 (/ISS) Q9NPG1 (/ISS) |
Midbrain morphogenesis GO:1904693
The developmental process by which a midbrain is generated and organized.
|
3 | Q9NPG1 (/TAS) Q9NPG1 (/TAS) Q9NPG1 (/TAS) |
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
|
2 | M0RCN5 (/IEP) Q8CJC4 (/IEP) |
Facial nucleus development GO:0021754
The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure.
|
2 | B1WB86 (/IMP) Q5TZ38 (/IMP) |
Anterior/posterior axon guidance GO:0033564
The process in which the migration of an axon growth cone is directed to a specific target site along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
|
2 | B1WB86 (/IMP) Q5TZ38 (/IMP) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
2 | M0RCN5 (/IEP) Q8CJC4 (/IEP) |
Response to electrical stimulus GO:0051602
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus.
|
2 | M0RCN5 (/IEP) Q8CJC4 (/IEP) |
Commissural neuron axon guidance GO:0071679
The process in which the migration of an axon growth cone of a commissural neuron is directed to its target in the brain in response to a combination of attractive and repulsive cues.
|
2 | B1WB86 (/IGI) Q5TZ38 (/IGI) |
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
1 | Q61086 (/IGI) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
1 | Q61086 (/IMP) |
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
|
1 | Q61086 (/IGI) |
Hair follicle development GO:0001942
The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.
|
1 | Q61086 (/IEP) |
Positive regulation of neuroblast proliferation GO:0002052
Any process that activates or increases the rate of neuroblast proliferation.
|
1 | Q61086 (/IMP) |
Neural crest cell fate specification GO:0014036
The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
1 | O42579 (/TAS) |
Midbrain development GO:0030901
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).
|
1 | Q61086 (/IGI) |
Regulation of protein localization GO:0032880
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
|
1 | O42579 (/IDA) |
Cell proliferation in midbrain GO:0033278
The multiplication or reproduction of cells, resulting in the expansion of a cell population in the midbrain.
|
1 | Q61086 (/IGI) |
Non-canonical Wnt signaling pathway GO:0035567
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.
|
1 | Q8CJC4 (/IGI) |
Post-anal tail morphogenesis GO:0036342
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.
|
1 | Q61086 (/IMP) |
Dopaminergic neuron axon guidance GO:0036514
The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q61086 (/IMP) |
Serotonergic neuron axon guidance GO:0036515
The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q61086 (/IMP) |
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
|
1 | Q61086 (/IGI) |
Negative regulation of mitotic cell cycle, embryonic GO:0045976
Any process that stops, prevents or reduces the rate or extent of progression through the embryonic mitotic cell cycle.
|
1 | Q61086 (/IMP) |
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
|
1 | Q8CJC4 (/IGI) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
1 | Q61086 (/ISO) |
Sympathetic ganglion development GO:0061549
The process whose specific outcome is the progression of a sympathetic ganglion over time, from its formation to the mature structure.
|
1 | Q61086 (/IMP) |
Negative regulation of execution phase of apoptosis GO:1900118
Any process that stops, prevents or reduces the frequency, rate or extent of execution phase of apoptosis.
|
1 | Q61086 (/IMP) |
Planar cell polarity pathway involved in axon guidance GO:1904938
Any Wnt signaling pathway, planar cell polarity pathway that is involved in axon guidance.
|
1 | Q61086 (/IMP) |
There are 12 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q61086 (/IDA) Q9NPG1 (/IDA) Q9NPG1 (/IDA) Q9NPG1 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | Q61086 (/TAS) Q9NPG1 (/TAS) Q9NPG1 (/TAS) Q9NPG1 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q9NPG1 (/IDA) Q9NPG1 (/IDA) Q9NPG1 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q61086 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q61086 (/ISO) |
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | Q61086 (/IDA) |
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
1 | Q61086 (/IDA) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
1 | Q61086 (/IDA) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q61086 (/IDA) |
Filopodium tip GO:0032433
The end of a filopodium distal to the body of the cell.
|
1 | Q61086 (/IDA) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
1 | Q61086 (/IDA) |
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
|
1 | Q61086 (/IDA) |