The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Frizzled cysteine-rich domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 5: secreted frizzled-related protein 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) D9ZGF6 (/IPI) P97401 (/IPI) Q6FHJ7 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
8 Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q95117 (/ISS) Q9IA95 (/ISS)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
7 Q6FHJ7 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
3 P97401 (/IPI) Q6FHJ7 (/IPI) Q9JLS4 (/IPI)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
2 P97401 (/IDA) Q6FHJ7 (/IDA)
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
1 Q9Z1N6 (/ISO)

There are 65 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
8 Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q95117 (/ISS) Q9IA95 (/ISS)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
8 Q6FHJ7 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q9JLS4 (/IDA)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
7 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q9JLS4 (/IDA)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
7 P97401 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
7 Q6FHJ7 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS) Q92765 (/NAS)
Skeletal system development GO:0001501
The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).
6 Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
6 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
6 Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI) Q92765 (/IGI)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
6 Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA) Q92765 (/IDA)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
3 Q6FHJ7 (/ISS) Q7YRN1 (/ISS) Q9JLS4 (/ISS)
Negative regulation of non-canonical Wnt signaling pathway GO:2000051
Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway.
3 Q6FHJ7 (/ISS) Q7YRN1 (/ISS) Q9JLS4 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
2 P97401 (/ISO) Q9Z1N6 (/ISO)
Chondrocyte proliferation GO:0035988
The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.
2 A0A0B5JQ70 (/IMP) Q9W6E0 (/IMP)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
2 P97401 (/ISO) Q9Z1N6 (/ISO)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
2 Q6FHJ7 (/IMP) Q9Z1N6 (/IMP)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
2 Q7YRN1 (/ISS) Q9JLS4 (/ISS)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 Q6FHJ7 (/IMP) Q9Z1N6 (/IMP)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
2 P97401 (/ISO) Q9Z1N6 (/ISO)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
1 Q6FHJ7 (/IDA)
Positive regulation of receptor internalization GO:0002092
Any process that activates or increases the frequency, rate or extent of receptor internalization.
1 Q9Z1N6 (/ISO)
Female pregnancy GO:0007565
The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.
1 Q9JLS4 (/IEP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q6FHJ7 (/IMP)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 Q6FHJ7 (/NAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q6FHJ7 (/IDA)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q9Z1N6 (/ISO)
Negative regulation of cell development GO:0010721
Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.
1 P97401 (/IDA)
Neural crest cell differentiation GO:0014033
The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell.
1 P97401 (/IEP)
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
1 Q9JLS4 (/TAS)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
1 P97401 (/IGI)
Negative regulation of Wnt signaling pathway GO:0030178
Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
1 P97401 (/ISO)
Negative regulation of cell growth GO:0030308
Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth.
1 P97401 (/ISO)
Regulation of BMP signaling pathway GO:0030510
Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway.
1 Q9Z1N6 (/IMP)
Response to estradiol GO:0032355
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.
1 Q9JLS4 (/IEP)
Positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region GO:0035593
Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region.
1 Q32N13 (/IDA)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 P97401 (/IDA)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 P97401 (/IGI)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 Q6FHJ7 (/IMP)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q6FHJ7 (/IDA)
Negative regulation of DNA-binding transcription factor activity GO:0043433
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
1 Q9Z1N6 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 Q9JLS4 (/IEP)
Positive regulation of fat cell differentiation GO:0045600
Any process that activates or increases the frequency, rate or extent of adipocyte differentiation.
1 P97401 (/ISO)
Positive regulation of epidermal cell differentiation GO:0045606
Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.
1 Q6FHJ7 (/IDA)
Positive regulation of epidermal cell differentiation GO:0045606
Any process that activates or increases the frequency, rate or extent of epidermal cell differentiation.
1 Q9Z1N6 (/ISO)
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9JLS4 (/IDA)
Negative regulation of JNK cascade GO:0046329
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the JNK cascade.
1 Q9Z1N6 (/ISO)
Decidualization GO:0046697
The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
1 Q9JLS4 (/IEP)
Response to glucocorticoid GO:0051384
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.
1 Q9JLS4 (/IEP)
Phosphate ion homeostasis GO:0055062
Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.
1 Q6FHJ7 (/IDA)
Phosphate ion homeostasis GO:0055062
Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell.
1 Q9Z1N6 (/ISO)
Convergent extension involved in organogenesis GO:0060029
The morphogenetic process in which an epithelium narrows along one axis and lengthens in a perpendicular axis contribution to the shaping of an organ.
1 P97401 (/IGI)
Mammary gland involution GO:0060056
The tissue remodeling that removes differentiated mammary epithelia during weaning.
1 Q9JLS4 (/IEP)
Bone morphogenesis GO:0060349
The process in which bones are generated and organized.
1 Q9Z1N6 (/ISO)
Negative regulation of cartilage development GO:0061037
Any process that decreases the rate, frequency, or extent of cartilage development, the process whose specific outcome is the progression of the cartilage over time, from its formation to the mature structure. Cartilage is a connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 P97401 (/IGI)
Somite development GO:0061053
The progression of a somite from its initial formation to the mature structure. Somites are mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
1 P97401 (/IEP)
Negative regulation of hepatocyte differentiation GO:0070367
Any process that stops or decreases the rate or extent of hepatocyte differentiation.
1 P97401 (/IDA)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 P97401 (/IGI)
Negative regulation of canonical Wnt signaling pathway GO:0090090
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q7YRN1 (/ISS)
Cochlea morphogenesis GO:0090103
The process in which the cochlea is generated and organized.
1 P97401 (/IGI)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q6FHJ7 (/IGI)
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
1 Q9Z1N6 (/ISO)
Positive regulation of keratinocyte apoptotic process GO:1902174
Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process.
1 Q6FHJ7 (/IDA)
Positive regulation of keratinocyte apoptotic process GO:1902174
Any process that activates or increases the frequency, rate or extent of keratinocyte apoptotic process.
1 Q9Z1N6 (/ISO)
Negative regulation of non-canonical Wnt signaling pathway GO:2000051
Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway.
1 Q9Z1N6 (/IMP)
Negative regulation of sodium-dependent phosphate transport GO:2000119
Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport.
1 Q6FHJ7 (/IDA)
Negative regulation of sodium-dependent phosphate transport GO:2000119
Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport.
1 Q9Z1N6 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
8 F1RYL4 (/HDA) P97401 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA) Q92765 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
6 Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS) Q92765 (/ISS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
6 Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS) Q92765 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
3 Q32N13 (/IDA) Q6FHJ7 (/IDA) Q9JLS4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q6FHJ7 (/IDA) Q9JLS4 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P97401 (/NAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q9Z1N6 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6FHJ7 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9Z1N6 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q9Z1N6 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q6FHJ7 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q9Z1N6 (/ISO)