The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Frizzled cysteine-rich domain
".
FunFam 16: Frizzled
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P18537 (/IPI) P18537 (/IPI) |
Wnt-protein binding GO:0017147
Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling.
|
2 | P18537 (/IPI) P18537 (/IPI) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
2 | P18537 (/IDA) P18537 (/IDA) |
Wnt-activated receptor activity GO:0042813
Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity.
|
1 | A0A0K3AWM6 (/ISS) |
There are 59 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Establishment or maintenance of cell polarity GO:0007163
Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.
|
3 | P18537 (/IMP) P18537 (/IMP) Q24760 (/IMP) |
Establishment of planar polarity GO:0001736
Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
|
2 | P18537 (/IEP) P18537 (/IEP) |
Establishment of imaginal disc-derived wing hair orientation GO:0001737
Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Morphogenesis of a polarized epithelium GO:0001738
The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
|
2 | A0A0K3AWM6 (/IGI) G5ECQ2 (/IGI) |
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
|
2 | P18537 (/IMP) P18537 (/IMP) |
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
|
2 | P18537 (/IGI) P18537 (/IGI) |
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Segment polarity determination GO:0007367
Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products.
|
2 | P18537 (/IGI) P18537 (/IGI) |
Salivary gland morphogenesis GO:0007435
The process in which the anatomical structures of the salivary gland are generated and organized.
|
2 | P18537 (/IMP) P18537 (/IMP) |
R3/R4 cell fate commitment GO:0007464
The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
|
2 | P18537 (/NAS) P18537 (/NAS) |
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Ommatidial rotation GO:0016318
The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Sensory organ precursor cell fate determination GO:0016360
The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Establishment of cell polarity GO:0030010
The specification and formation of anisotropic intracellular organization or cell growth patterns.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Regulation of actin filament bundle assembly GO:0032231
Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles.
|
2 | P18537 (/IGI) P18537 (/IGI) |
Regulation of tube length, open tracheal system GO:0035159
Ensuring that a tube in an open tracheal system is of the correct length.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Regulation of hemocyte proliferation GO:0035206
Any process that modulates the frequency, rate or extent of hemocyte proliferation. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. An example of this is found in Drosophila melanogaster.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Chitin-based larval cuticle pattern formation GO:0035293
The process that gives rise to the patterns of cell differentiation in the chitin-based larval cuticle. An example of this is found in Drosophila melanogaster.
|
2 | P18537 (/IGI) P18537 (/IGI) |
Imaginal disc-derived wing hair organization GO:0035317
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of an imaginal disc-derived wing hair. A wing hair is an actin-rich, polarized, non-sensory apical projection that protrudes from each of the approximately 30,000 wing epithelial cells. An example of this is found in Drosophila melanogaster.
|
2 | P18537 (/IGI) P18537 (/IGI) |
Imaginal disc-derived wing hair site selection GO:0035320
Determination of the site in the cell of an imaginal disc-derived wing at which a prehair initiates outgrowth. Restriction of prehair initiation to the distalmost part of a cell is essential to ensure that each wing epithelial cell produces one adult hair that points distally.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Establishment of ommatidial planar polarity GO:0042067
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Establishment of ommatidial planar polarity GO:0042067
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.
|
2 | P18537 (/TAS) P18537 (/TAS) |
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
|
2 | P18537 (/IGI) P18537 (/IGI) |
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Canonical Wnt signaling pathway GO:0060070
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
|
2 | P18537 (/IGI) P18537 (/IGI) |
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
2 | P18537 (/TAS) P18537 (/TAS) |
Neuroblast migration GO:0097402
The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.
|
2 | A0A0K3AWM6 (/IGI) G5ECQ2 (/IGI) |
Motor neuron migration GO:0097475
The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.
|
2 | A0A0K3AWM6 (/IGI) G5ECQ2 (/IGI) |
Positive regulation of axon guidance GO:1902669
Any process that activates or increases the frequency, rate or extent of axon guidance.
|
2 | P18537 (/IMP) P18537 (/IMP) |
Sensory neuron migration GO:1904937
The orderly movement of a sensory neuron from one site to another.
|
2 | A0A0K3AWM6 (/IGI) G5ECQ2 (/IGI) |
Positive regulation of motor neuron migration GO:1905485
Any process that activates or increases the frequency, rate or extent of motor neuron migration.
|
2 | A0A0K3AWM6 (/IGI) G5ECQ2 (/IGI) |
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | A0A0K3AWM6 (/IGI) |
Establishment of mitotic spindle orientation GO:0000132
A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures.
|
1 | A0A0K3AWM6 (/IMP) |
Endodermal cell fate specification GO:0001714
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
1 | A0A0K3AWM6 (/IGI) |
Endodermal cell fate specification GO:0001714
The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.
|
1 | A0A0K3AWM6 (/IMP) |
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
1 | A0A0K3AWM6 (/IGI) |
Gastrulation GO:0007369
A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm.
|
1 | A0A0K3AWM6 (/IMP) |
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
|
1 | A0A0K3AWM6 (/IMP) |
Wnt signaling pathway GO:0016055
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.
|
1 | A0A0K3AWM6 (/ISS) |
Engulfment of apoptotic cell GO:0043652
The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.
|
1 | A0A0K3AWM6 (/IMP) |
Embryonic digestive tract morphogenesis GO:0048557
The process in which the anatomical structures of the digestive tract are generated and organized during embryonic development. The digestive tract is the anatomical structure through which food passes and is processed.
|
1 | A0A0K3AWM6 (/IGI) |
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
|
1 | A0A0K3AWM6 (/IMP) |
Wnt signaling pathway, regulating spindle positioning GO:0060069
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with the positioning of the mitotic spindle.
|
1 | A0A0K3AWM6 (/IMP) |
Left/right axis specification GO:0070986
The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
|
1 | A0A0K3AWM6 (/IGI) |
Left/right axis specification GO:0070986
The establishment, maintenance and elaboration of the left/right axis. The left/right axis is defined by a line that runs orthogonal to both the anterior/posterior and dorsal/ventral axes. Each side is defined from the viewpoint of the organism rather of the observer (as per anatomical axes).
|
1 | A0A0K3AWM6 (/IMP) |
Neuroblast migration GO:0097402
The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.
|
1 | A0A0K3AWM6 (/IMP) |
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
1 | A0A0K3AWM6 (/IDA) |
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
1 | A0A0K3AWM6 (/IGI) |
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
|
1 | A0A0K3AWM6 (/IMP) |
Positive regulation of distal tip cell migration GO:1903356
Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
|
1 | A0A0K3AWM6 (/IGI) |
Positive regulation of distal tip cell migration GO:1903356
Any process that activates or increases the frequency, rate or extent of distal tip cell migration.
|
1 | A0A0K3AWM6 (/IMP) |
Interneuron migration GO:1904936
The orderly movement of an interneuron from one site to another.
|
1 | A0A0K3AWM6 (/IGI) |
Positive regulation of anterior/posterior axon guidance GO:1905488
Any process that activates or increases the frequency, rate or extent of anterior/posterior axon guidance.
|
1 | A0A0K3AWM6 (/IGI) |
Positive regulation of sensory neuron axon guidance GO:1905491
Any process that activates or increases the frequency, rate or extent of sensory neuron axon guidance.
|
1 | A0A0K3AWM6 (/IGI) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
3 | P18537 (/NAS) P18537 (/NAS) Q24760 (/NAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P18537 (/TAS) P18537 (/TAS) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P18537 (/IDA) P18537 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
2 | P18537 (/TAS) P18537 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | A0A0K3AWM6 (/ISS) |