CATH Superfamily 1.10.1670.10
Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)
".
FunFam 1: Endonuclease III
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
DNA N-glycosylase activity GO:0019104
Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
|
134 |
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
(124 more) |
Oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity GO:0000703
Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site.
|
125 |
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
(115 more) |
DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906
Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
|
125 |
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
(115 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
125 |
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
P0AB83 (/IPI)
(115 more) |
4 iron, 4 sulfur cluster binding GO:0051539
Interacting selectively and non-covalently with a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
|
125 |
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
(115 more) |
Double-stranded DNA binding GO:0003690
Interacting selectively and non-covalently with double-stranded DNA.
|
9 | P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) |
DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906
Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).
|
6 | Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Base-excision repair, AP site formation GO:0006285
The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired.
|
125 |
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
(115 more) |
Cellular response to UV GO:0034644
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers.
|
125 |
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
P0AB83 (/IDA)
(115 more) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
9 | P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) P9WQ11 (/IDA) |
DNA repair GO:0006281
The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
|
6 | Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) Q9KT92 (/ISS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
|
9 | P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
9 | P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) P9WQ11 (/HDA) |